{"id":2455,"date":"2026-09-17T20:12:12","date_gmt":"2026-09-17T20:12:12","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/glp-3-r3t-capsules\/"},"modified":"2026-10-22T14:47:39","modified_gmt":"2026-10-22T14:47:39","slug":"glp-3-r3t-capsules","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/de\/produkt\/glp-3-r3t-capsules\/","title":{"rendered":"GLP-3 R3T Capsules"},"content":{"rendered":"<p><strong>GLP-3 R3T \u2013 V\u00fdzkumn\u00e9 kapsle pro laboratorn\u00ed \u00fa\u010dely (2 mg \/ kapsle, 60 ks)<\/strong><\/p>\n<p><i>Syntetick\u00fd biologicky aktivn\u00ed acylovan\u00fd peptidov\u00fd tri-agonista receptor\u016f GLP-1R, GIPR a GCGR v pevn\u00e9 analytick\u00e9 matrici pro in vitro v\u00fdzkum multi-receptorov\u00e9 signalizace, bun\u011b\u010dn\u00e9 bioenergetiky, modulace intracelul\u00e1rn\u00edho cAMP a lipidov\u00e9ho toku v prim\u00e1rn\u00edch bun\u011b\u010dn\u00fdch lini\u00edch<\/i><\/p>\n<p><strong>P\u0159ehled a mechanismus \u00fa\u010dinku (In Vitro)<\/strong><\/p>\n<p><strong>GLP-3 R3T<\/strong> (laboratorn\u00ed k\u00f3dov\u00e9 ozna\u010den\u00ed pro pokro\u010dil\u00fd acylovan\u00fd tri-agonistick\u00fd peptid s konjugovanou dikyselinovou lipidovou kotvou) je vysoce stabiln\u00ed polypeptid navr\u017een\u00fd jako vyv\u00e1\u017een\u00fd multi-c\u00edlov\u00fd ligand schopn\u00fd sou\u010dasn\u011b aktivovat t\u0159i kl\u00ed\u010dov\u00e9 metabolick\u00e9 receptory: receptor pro glukagonu podobn\u00fd peptid-1 (<strong>GLP-1R<\/strong>), receptor pro gluk\u00f3zo-dependentn\u00ed inzulinotropn\u00ed polypeptid (<strong>GIPR<\/strong>) a glukagonov\u00fd receptor (<strong>GCGR<\/strong>). Enkapsulace do standardizovan\u00e9 pevn\u00e9 matrice zaji\u0161\u0165uje p\u0159esn\u00e9 odm\u011b\u0159en\u00ed alikvotn\u00edho mno\u017estv\u00ed l\u00e1tky a jej\u00ed ochranu p\u0159ed vzdu\u0161nou vlhkost\u00ed a p\u0159ed\u010dasnou degradac\u00ed p\u0159ed laboratorn\u00ed p\u0159\u00edpravou testovac\u00edch roztok\u016f:<\/p>\n<ul>\n<li><strong>Synergick\u00fd tri-agonistick\u00fd profil (GLP-1R \/ GIPR \/ GCGR):<\/strong> Koordinovan\u00e1 stimulace v\u0161ech t\u0159\u00ed receptor\u016f sp\u0159a\u017een\u00fdch s G-proteiny (G\u03b1s) vyvol\u00e1v\u00e1 aditivn\u00ed aktivaci adenylylcykl\u00e1zy a masivn\u00ed n\u00e1r\u016fst intracelul\u00e1rn\u00ed hladiny cAMP, co\u017e p\u0159evy\u0161uje \u00fa\u010dinek mono- i du\u00e1ln\u00edch agonist\u016f.<\/li>\n<li><strong>Potenciace mitochondri\u00e1ln\u00ed respirace a oxidace mastn\u00fdch kyselin:<\/strong> Sou\u010dasn\u00e1 aktivace GCGR a GIPR v\u011btv\u00ed indukuje fosforylaci AMPK a stimuluje expresi enzym\u016f odpov\u011bdn\u00fdch za \u03b2-oxidaci v prim\u00e1rn\u00edch hepatocytech a adipocyt\u00e1rn\u00edch bun\u011b\u010dn\u00fdch modelech in vitro.<\/li>\n<li><strong>Modulace bun\u011b\u010dn\u00e9ho stresu a cytoprotekce:<\/strong> Aktivace GLP-1R a GIPR sign\u00e1ln\u00edch drah sni\u017euje expresi biomarker\u016f stresu endoplazmatick\u00e9ho retikula (ER stress) a chr\u00e1n\u00ed bun\u011b\u010dn\u00e9 linie p\u0159ed apopt\u00f3zou vyvolanou lipotoxicitou \u010di oxida\u010dn\u00edm p\u0159et\u00ed\u017een\u00edm.<\/li>\n<li><strong>P\u0159esn\u00e9 d\u00e1vkov\u00e1n\u00ed pro in vitro testov\u00e1n\u00ed:<\/strong> Pevn\u00e1 forma kapsle slou\u017e\u00ed jako stabiln\u00ed nosi\u010d p\u0159esn\u011b odm\u011b\u0159en\u00e9ho mno\u017estv\u00ed lyofilizovan\u00e9ho analytick\u00e9ho standardu (2 mg) pro snadnou p\u0159\u00edpravu s\u00e9riov\u00fdch \u0159ed\u011bn\u00ed v bun\u011b\u010dn\u00fdch m\u00e9di\u00edch nebo pufrech.<\/li>\n<\/ul>\n<p><strong>Technick\u00e1 a chemick\u00e1 specifikace<\/strong><\/p>\n<ul>\n<li><strong>Klasifikace:<\/strong> V\u00fdzkumn\u00fd peptidov\u00fd tri-agonista v pevn\u00e9 matrici \/ Reagen\u010dn\u00ed analytick\u00e9 kapsle (RUO)<\/li>\n<li><strong>Obsah aktivn\u00ed l\u00e1tky:<\/strong> 2 mg na kapsli (\u00b12\u2009%)<\/li>\n<li><strong>Velikost balen\u00ed:<\/strong> 60 v\u00fdzkumn\u00fdch kapsl\u00ed v laboratorn\u00edm kontejneru s vysou\u0161edlem<\/li>\n<li><strong>Forma:<\/strong> Pevn\u00e1 reagen\u010dn\u00ed matrice \/ enkapsulovan\u00fd pr\u00e1\u0161kov\u00fd standard<\/li>\n<li><strong>Identifikace:<\/strong> Ov\u011b\u0159ena analytickou HPLC a hmotnostn\u00ed spektrometri\u00ed (MS)<\/li>\n<li><strong>Doporu\u010den\u00fd postup rekonstituce matrice:<\/strong> Obsah kapsle je ur\u010den k rozpu\u0161t\u011bn\u00ed ve vhodn\u00e9m laboratorn\u00edm m\u00e9diu (nap\u0159. steriln\u00ed PBS s m\u00edrn\u011b z\u00e1sadit\u00fdm pH 7,4\u20138,0, DMSO pro stock roztoky nebo steriln\u00ed voda) za vzniku p\u0159esn\u011b kalibrovan\u00e9 koncentrace pro bun\u011b\u010dn\u00e9 eseje.<\/li>\n<li><strong>Podm\u00ednky skladov\u00e1n\u00ed:<\/strong> Uchov\u00e1vat p\u0159i teplot\u011b 15\u201325 \u00b0C v suchu, temnu a t\u011bsn\u011b uzav\u0159en\u00e9m origin\u00e1ln\u00edm obalu s desikantem. Pro dlouhodobou archivaci standard\u016f doporu\u010deno skladov\u00e1n\u00ed p\u0159i -20 \u00b0C.<\/li>\n<\/ul>\n<p><strong>Odborn\u00e9 zdroje a literatura<\/strong><\/p>\n<ul>\n<li><i>Finan, B., et al.<\/i> A balanced unimolecular tri-agonist targeting GLP-1, GIP, and glucagon receptors enhances cellular energy expenditure and metabolic control. <i>Nature Medicine<\/i>, 2015.<\/li>\n<li><i>Coskun, T., et al.<\/i> LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist: In vitro pharmacology and robust multi-receptor signaling cascades. <i>Cell Metabolism<\/i>, 2022.<\/li>\n<li><i>Gault, V. A., et al.<\/i> Multi-incretin receptor agonists in cellular metabolic homeostasis: Mechanisms of receptor cross-talk and cAMP dynamics. <i>Frontiers in Endocrinology<\/i>, 2020.<\/li>\n<li><i>Knerr, P. J., et al.<\/i> Next-generation peptide multi-agonists: Structural optimization, fatty acid conjugation, and in vitro stability profiling. <i>Journal of Medicinal Chemistry<\/i>, 2021.<\/li>\n<\/ul>\n<p><strong>Pr\u00e1vn\u00ed prohl\u00e1\u0161en\u00ed a podm\u00ednky n\u00e1kupu<\/strong><\/p>\n<p>Tento produkt je klasifikov\u00e1n a dod\u00e1v\u00e1n <strong>v\u00fdhradn\u011b pro laboratorn\u00ed, v\u011bdeck\u00e9 a in vitro v\u00fdzkumn\u00e9 \u00fa\u010dely (Research Use Only \u2013 RUO)<\/strong>. Slou\u010denina ani kapslov\u00e1 matrice nejsou l\u00e9\u010divem, l\u00e9kem, dopl\u0148kem stravy, kosmetick\u00fdm p\u0159\u00edpravkem ani l\u00e1tkou ur\u010denou pro hum\u00e1nn\u00ed \u010di veterin\u00e1rn\u00ed spot\u0159ebu, peror\u00e1ln\u00ed po\u017eit\u00ed, p\u0159\u00edmou aplikaci, injek\u010dn\u00ed pod\u00e1n\u00ed nebo diagnostick\u00e9 pou\u017eit\u00ed.<\/p>\n<p>Odesl\u00e1n\u00edm objedn\u00e1vky kupuj\u00edc\u00ed v\u00fdslovn\u011b potvrzuje, \u017ee <strong>dovr\u0161il v\u011bk minim\u00e1ln\u011b 18 let<\/strong>, disponuje pot\u0159ebnou odbornou zp\u016fsobilost\u00ed i technick\u00fdm vybaven\u00edm pro manipulaci s v\u00fdzkumn\u00fdmi materi\u00e1ly a je v pln\u00e9m rozsahu sezn\u00e1men s bezpe\u010dnostn\u00edmi protokoly nakl\u00e1d\u00e1n\u00ed s v\u00fdzkumn\u00fdmi l\u00e1tkami. Prod\u00e1vaj\u00edc\u00ed nenese \u017e\u00e1dnou odpov\u011bdnost za pou\u017eit\u00ed produktu v rozporu s t\u011bmito podm\u00ednkami.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>\u00da\u010del pou\u017eit\u00ed:<\/b><span style=\"font-weight: 400;\"> Tento produkt je dod\u00e1v\u00e1n <\/span><b>v\u00fdhradn\u011b pro laboratorn\u00ed, v\u011bdeck\u00e9 a v\u00fdzkumn\u00e9 \u00fa\u010dely (Research Use Only \/ in vitro)<\/b><span style=\"font-weight: 400;\">. Nejedn\u00e1 se o l\u00e9\u010divo, potravinu ani dopln\u011bk stravy. Slou\u010denina v pevn\u00e9m nosi\u010di nen\u00ed ur\u010dena k aplikaci, spot\u0159eb\u011b ani k jak\u00e9mukoliv terapeutick\u00e9mu pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Forma a balen\u00ed:<\/b><span style=\"font-weight: 400;\"> Produkt obsahuje p\u0159esn\u011b nav\u00e1\u017eenou v\u00fdzkumnou l\u00e1tku v uzav\u0159en\u00e9m kapslov\u00e9m nosi\u010di pro snadnou laboratorn\u00ed manipulaci.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Doporu\u010den\u00e9 skladov\u00e1n\u00ed:<\/b><span style=\"font-weight: 400;\"> Uchov\u00e1vejte v origin\u00e1ln\u00edm uzav\u0159en\u00e9m obalu na such\u00e9m, chladn\u00e9m a temn\u00e9m m\u00edst\u011b p\u0159i teplot\u011b do 20 \u00b0C. Chra\u0148te p\u0159ed vlhkost\u00ed a p\u0159\u00edm\u00fdm slune\u010dn\u00edm z\u00e1\u0159en\u00edm.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Ilustra\u010dn\u00ed vyobrazen\u00ed:<\/b><span style=\"font-weight: 400;\"> Obr\u00e1zek produktu slou\u017e\u00ed pouze k <\/span><b>ilustra\u010dn\u00edm \u00fa\u010del\u016fm<\/b><span style=\"font-weight: 400;\">. Barevn\u00e9 proveden\u00ed kapsl\u00ed, form\u00e1t balen\u00ed nebo design laboratorn\u00ed etikety se mohou li\u0161it v z\u00e1vislosti na konkr\u00e9tn\u00ed v\u00fdrobn\u00ed \u0161ar\u017ei.<\/span><\/li>\n<\/ul>\n","protected":false},"featured_media":2456,"template":"","meta":[],"product_brand":[],"product_cat":[52],"product_tag":[],"class_list":["post-2455","product","type-product","status-publish","has-post-thumbnail","product_cat-forschungskapseln","first","instock","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>GLP-3 R3T Capsules - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nextrabiochem.eu\/de\/produkt\/glp-3-r3t-capsules\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"GLP-3 R3T Capsules - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"\u00da\u010del pou\u017eit\u00ed: Tento produkt je dod\u00e1v\u00e1n v\u00fdhradn\u011b pro laboratorn\u00ed, v\u011bdeck\u00e9 a v\u00fdzkumn\u00e9 \u00fa\u010dely (Research Use Only \/ in vitro). Nejedn\u00e1 se o l\u00e9\u010divo, potravinu ani dopln\u011bk stravy. Slou\u010denina v pevn\u00e9m nosi\u010di nen\u00ed ur\u010dena k aplikaci, spot\u0159eb\u011b ani k jak\u00e9mukoliv terapeutick\u00e9mu pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.  Forma a balen\u00ed: Produkt obsahuje p\u0159esn\u011b nav\u00e1\u017eenou v\u00fdzkumnou l\u00e1tku v uzav\u0159en\u00e9m kapslov\u00e9m nosi\u010di pro snadnou laboratorn\u00ed manipulaci.  Doporu\u010den\u00e9 skladov\u00e1n\u00ed: Uchov\u00e1vejte v origin\u00e1ln\u00edm uzav\u0159en\u00e9m obalu na such\u00e9m, chladn\u00e9m a temn\u00e9m m\u00edst\u011b p\u0159i teplot\u011b do 20 \u00b0C. Chra\u0148te p\u0159ed vlhkost\u00ed a p\u0159\u00edm\u00fdm slune\u010dn\u00edm z\u00e1\u0159en\u00edm.  Ilustra\u010dn\u00ed vyobrazen\u00ed: Obr\u00e1zek produktu slou\u017e\u00ed pouze k ilustra\u010dn\u00edm \u00fa\u010del\u016fm. 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Nejedn\u00e1 se o l\u00e9\u010divo, potravinu ani dopln\u011bk stravy. Slou\u010denina v pevn\u00e9m nosi\u010di nen\u00ed ur\u010dena k aplikaci, spot\u0159eb\u011b ani k jak\u00e9mukoliv terapeutick\u00e9mu pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.  Forma a balen\u00ed: Produkt obsahuje p\u0159esn\u011b nav\u00e1\u017eenou v\u00fdzkumnou l\u00e1tku v uzav\u0159en\u00e9m kapslov\u00e9m nosi\u010di pro snadnou laboratorn\u00ed manipulaci.  Doporu\u010den\u00e9 skladov\u00e1n\u00ed: Uchov\u00e1vejte v origin\u00e1ln\u00edm uzav\u0159en\u00e9m obalu na such\u00e9m, chladn\u00e9m a temn\u00e9m m\u00edst\u011b p\u0159i teplot\u011b do 20 \u00b0C. Chra\u0148te p\u0159ed vlhkost\u00ed a p\u0159\u00edm\u00fdm slune\u010dn\u00edm z\u00e1\u0159en\u00edm.  Ilustra\u010dn\u00ed vyobrazen\u00ed: Obr\u00e1zek produktu slou\u017e\u00ed pouze k ilustra\u010dn\u00edm \u00fa\u010del\u016fm. 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