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BPC-157 + TB-500

BPC-157 + TB-500

From 52,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: BB10 Category:
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Description

BPC-157 + TB-500

Synthetic dual peptide complex for in vitro research on synergistic actin sequestration, cell motility, angiogenesis, and structural tissue repair

Overview & Mechanism of Action (In Vitro)

BPC-157 + TB-500 is a laboratory blend combining two complementary research peptides: the stable gastric pentadecapeptide BPC-157 and the synthetic thymosin β4 fragment (TB-500). In molecular and experimental biology, it serves as an integrated model for studying the concurrent activation of vascular, cellular, and cytoskeletal repair pathways:

  • Synergistic Promotion of Cell Motility & Migration: TB-500 regulates actin filament dynamics via G-actin sequestration and lamellipodia formation, while BPC-157 activates the FAK / paxillin (focal adhesion kinase) phosphorylation axis, yielding accelerated directional cell migration in experimental wound healing assays (scratch assays).
  • Complementary Angiogenic Stimulation: Dual enhancement of microvascular formation in vitro — BPC-157 promotes VEGFR2 phosphorylation and eNOS pathway activation, while TB-500 drives endothelial cell migration and capillary tube formation.
  • Extracellular Matrix (ECM) Organization: Investigation of coordinated collagen and proteoglycan synthesis in fibroblasts and tenocytes, alongside the modulation of matrix metalloproteinases (MMPs) to evaluate anti-fibrotic repair dynamics.
  • Cellular Anti-Inflammatory Modulation: Dual suppression of NF-κB nuclear translocation, reducing the transcription and release of pro-inflammatory cytokines (TNF-α, IL-6).

Technical & Chemical Specifications

  • Classification: Multi-Peptide Research Complex / Dual Tissue Repair Factor
  • Blend Composition: BPC-157 + TB-500
  • Form: Sterile lyophilized white powder (cake)
  • Component Identification: Verified via Mass Spectrometry (MS) and analytical HPLC
  • Recommended Reconstitution Solvent: Sterile bacteriostatic water or phosphate-buffered saline (PBS)
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C and utilize within standard experimental protocol timelines.

Scientific References & Literature

  • Sikiric, P., et al. Stable gastric pentadecapeptide BPC 157: In vitro and in vivo mechanisms in cellular protection and angiogenesis. Current Pharmaceutical Design, 2018.
  • Goldstein, A. L., et al. Thymosin beta 4: Actin-sequestering protein and its multifaceted roles in cellular motility and tissue repair. Annals of the New York Academy of Sciences, 2007.
  • Chang, C. H., et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology, 2011.
  • Philp, D., et al. The actin-binding site of thymosin beta 4 promotes cell migration and accelerates wound healing in experimental models. FASEB Journal, 2003.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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