Description

BPC-157 + TB-500 – Pre-filled Laboratory Cartridge for In Vitro Research (10 mg + 10 mg / 3 ml)

Dual synthetic research peptide complex comprising the gastric pentadecapeptide fragment (BPC-157) and the biomimetic actin-sequestering thymosin  fragment (TB-500) in a pre-formulated stabilized buffered solution for in vitro research on synergistic angiogenesis, cytoskeletal dynamics, fibroblast motility, and cellular cytoprotection

Overview & Mechanism of Action (In Vitro)

This dual peptide complex combines two distinct molecular mechanisms into a single calibrated solution for in vitro cell biology and experimental tissue engineering:

• Synergistic Activation of Angiogenic Pathways: BPC-157 stimulates VEGFR2 phosphorylation and endothelial nitric oxide synthase (eNOS) activation, while TB-500 enhances vascular endothelial cell motility and capillary-like tube network assembly in vitro via matrix metalloproteinase (MMP) modulation.
• Dual Cytoskeletal Remodeling & Migration Dynamics: TB-500 sequesters monomeric G-actin in a 1:1 ratio to preserve cytoskeletal turnover, while BPC-157 engages the FAK-paxillin focal adhesion axis, accelerating fibroblast and tenocyte migration in monolayer scratch assays.
• Enhanced Cytoprotection & Extracellular Matrix Synthesis: The co-administration profile stimulates type I and III collagen gene transcription alongside Akt phosphorylation and caspase-3 inhibition, protecting cultured cells from apoptosis under hypoxic or oxidative stress in vitro.
• Pre-formulated Format for Precise Laboratory Dispensing: A stable liquid formulation containing both peptides in an exact 1:1 ratio (20 mg total active peptide content / 3 ml) eliminates errors associated with separate manual reconstitution and blending steps.

Technical & Chemical Specifications

• Classification: Dual Research Peptide Standard (Biomimetic Pentadecapeptide + Actin-Binding Peptide) / Research Peptide Solution (RUO)
• Product Format: Pre-filled calibrated laboratory cartridge (3 ml volume)
• Active Content per Cartridge:
  • BPC-157: 10 mg (approx. 3.33 mg/ml concentration)
  • TB-500: 10 mg (approx. 3.33 mg/ml concentration)
  • Total Peptide Strength: 20 mg / 3 ml (approx. 6.67 mg/ml total concentration)
• Form: Sterile stabilized solution / Ready-to-Use (RTU)
• Solution Matrix: Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)
• Compatibility: Compatible with standard laboratory dispensing pens and micro-dispensers for 3 ml cartridges (dispensing pen/injector is not included in the package)
• Storage Conditions: Store at 2–8 °C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.

Scientific References & Literature

• Sikiric, P., et al. Stable gastric pentadecapeptide BPC 157 in cellular systems: In vitro mechanisms of endothelial survival, VEGF upregulation, and tissue remodeling. Current Pharmaceutical Design, 2018.
• Goldstein, A. L., et al. Thymosin beta4: Actin-sequestering protein and its multifunctional role in cellular migration and tissue repair in vitro. Annals of the New York Academy of Sciences, 2012.
• Bock-Marquette, I., et al. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration and survival in vitro. Nature, 2004.
• Hsieh, F. C., et al. Pentadecapeptide BPC 157 enhances migration and proliferation of fibroblasts through focal adhesion kinase (FAK) and paxillin activation in vitro. Molecular and Cellular Biochemistry, 2017.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). The stabilized peptide solution and mechanical cartridge are not drugs, medicines, weight-loss agents, dietary supplements, or cosmetic products, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.