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BPC-157

BPC-157

From 22,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: BC5 Category:
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Description

BPC-157

Synthetic pentadecapeptide derived from gastric BPC protein for in vitro research on angiogenesis, cytoprotection, extracellular matrix remodeling, and tissue homeostasis

Overview & Mechanism of Action (In Vitro)

BPC-157 (Body Protection Compound-157) is a synthetic 15-amino acid peptide with the sequence (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val), structurally derived from the naturally occurring gastric juice protein BPC. In molecular biology, gastroenterology, and experimental regenerative medicine, it serves as a primary reference model for studying pleiotropic cytoprotective and repair pathways:

  • Modulation of Angiogenesis & Growth Factor Cascades: Promotes VEGFR2 (vascular endothelial growth factor receptor 2) phosphorylation on endothelial cells, activating the VEGF signaling cascade and stimulating capillary tube formation (tube formation assays).
  • Regulation of Nitric Oxide (NO) Synthesis: Modulates endothelial nitric oxide synthase (eNOS) activity, facilitating the study of cellular vasomotor dynamics and repair signaling responses in vitro.
  • FAK / Paxillin Pathway Activation & Cell Adhesion: Stimulates focal adhesion kinase (FAK) and paxillin phosphorylation in cultured fibroblasts and endothelial cells, accelerating directional cell migration and matrix adherence.
  • Downregulation of Pro-Inflammatory Mediators: Suppresses NF-κB activation, downregulating pro-inflammatory cytokine expression (TNF-α, IL-6) and reducing myeloperoxidase activity in cellular injury models.
  • Chemical & Enzymatic Stability: Exhibits notable resistance across a wide pH range (including low-pH conditions) and elevated enzymatic stability against gastrointestinal and tissue proteases.

Technical & Chemical Specifications

  • Classification: Research Peptide / Stable Gastric Pentadecapeptide Fragment
  • Amino Acid Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
  • Form: Sterile lyophilized white powder (cake)
  • Molecular Weight Identification: Confirmed via Mass Spectrometry (MS)
  • Recommended Reconstitution Solvent: Sterile bacteriostatic water or phosphate-buffered saline (PBS)
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C and utilize within standard experimental protocol timelines.

Scientific References & Literature

  • Sikiric, P., et al. Stable gastric pentadecapeptide BPC 157: In vitro and in vivo mechanisms in cellular protection and angiogenesis. Current Pharmaceutical Design, 2018.
  • Chang, C. H., et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology, 2011.
  • Hsieh, F. C., et al. BPC 157 promotes cellular migration and FAK/paxillin phosphorylation in wound-healing assays. Molecular Biology Reports, 2017.
  • Seiwerth, S., et al. BPC 157 and blood vessels: Modulation of endothelial repair cascades and angiogenesis in vitro and in vivo. Current Vascular Pharmacology, 2014.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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