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Thymosin Alpha 1

Thymosin Alpha 1

From 33,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: TA5 Category:
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Description

Thymosin Alpha 1

Synthetic 28-amino acid peptide for in vitro research on innate and adaptive immune modulation, T-cell maturation, and TLR signaling

Overview & Mechanism of Action (In Vitro)

Thymosin Alpha 1 (Tα1) is a synthetic acetylated peptide composed of 28 amino acids with the sequence (Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH), originally isolated from thymic fraction 5. In cellular biology, immunology, and oncology research, it serves as a reference modulator of immune mechanisms:

  • T-Cell Maturation & Differentiation: Stimulation of pre-T cell differentiation into mature helper (CD4+) and cytotoxic (CD8+) T-lymphocytes, alongside upregulation of interleukin-2 receptor (IL-2R) expression.
  • Toll-Like Receptor Activation (TLR2, TLR9): Binding to specific pattern recognition receptors on dendritic cells and macrophages, activating the MyD88-dependent signaling cascade and downstream NF-κB transcription.
  • Cytokine Balance Modulation: Augmentation of Th1-type cytokine expression (IFN-γ, IL-2) and enhancement of Natural Killer (NK) cell cytotoxic activity in culture systems.
  • Antiviral & Antitumor Research Models: Investigating the peptide’s ability to upregulate MHC class I expression on virally infected or transformed cells, facilitating antigen presentation to effector immune cells.

Technical & Chemical Specifications

  • Classification: Research Peptide / Thymic Immunomodulator
  • Amino Acid Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
  • Form: Sterile lyophilized white powder (cake)
  • Molecular Weight Identification: Confirmed via Mass Spectrometry (MS)
  • Recommended Reconstitution Solvent: Sterile bacteriostatic water or phosphate-buffered saline (PBS)
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C and utilize within standard experimental protocol timelines.

Scientific References & Literature

  • Goldstein, A. L., et al. Thymosin alpha 1: Isolation and sequence analysis of an immunologically active thymic polypeptide. Proceedings of the National Academy of Sciences, 1977.
  • Romani, L., et al. Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through Toll-like receptor signaling. Blood, 2004.
  • Matteucci, C., et al. Thymosin alpha 1 and its role in modulating the innate and adaptive immune response: Molecular mechanisms. Annals of the New York Academy of Sciences, 2012.
  • King, R., & Tuthill, C. Immune modulation with thymosin alpha 1: Mechanisms of action in vitro and biological targets. Expert Opinion on Biological Therapy, 2016.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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