{"id":101,"date":"2026-09-03T07:32:31","date_gmt":"2026-09-03T07:32:31","guid":{"rendered":"https:\/\/nextrabiochem.eu\/?post_type=product&#038;p=101"},"modified":"2026-09-03T09:35:55","modified_gmt":"2026-09-03T09:35:55","slug":"thymosin-alpha-1-10mg","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/thymosin-alpha-1-10mg\/","title":{"rendered":"Thymosin Alpha 1 10mg"},"content":{"rendered":"<p><strong>Thymosin Alpha 1 \u2013 Pre-filled Laboratory Cartridge for In Vitro Research (10 mg \/ 3 ml)<\/strong><\/p>\n<p><em>Synthetic biomimetic 28-amino acid thymic peptide fragment (<\/em><em>-acetyl-thymosin <\/em><em>) in a pre-formulated stabilized buffered solution for in vitro research on TLR-mediated signaling pathways, T-cell maturation, MHC class I surface expression, and Th1 cytokine profiling<\/em><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>Thymosin Alpha 1<\/strong> () is a synthetic 28-amino acid acidic peptide derived from the native thymic precursor prothymosin . In cellular immunology, molecular oncology, and in vitro viral research, it serves as a primary reference standard for investigating lymphocyte differentiation, antigen presentation mechanisms, and intracellular immune signaling cascades across cell culture models:<\/p>\n<ul>\n<li><strong>Modulation of Toll-like Receptor Signaling (TLR2, TLR9):<\/strong> Triggers MyD88-dependent signaling pathways in dendritic cells and macrophages, inducing nuclear translocation of NF-B and modulating the transcription of innate immunity genes in vitro.<\/li>\n<li><strong>Stimulation of T-Lymphocyte Differentiation &amp; Maturation:<\/strong> Promotes the terminal differentiation of stem\/progenitor cells into functional \u00a0helper and \u00a0cytotoxic T-cell populations, shifting cytokine secretion profiles toward a Th1 phenotype (upregulation of IFN-, IL-2).<\/li>\n<li><strong>Upregulation of Antigen-Presenting Complexes:<\/strong> Enhances the transcription and membrane expression of Major Histocompatibility Complex Class I (MHC-I) molecules and -microglobulin across primary cells and experimental transformed cell lines in vitro.<\/li>\n<li><strong>Cellular Stress Reduction &amp; Antioxidant Defense:<\/strong> Enhances endogenous antioxidant enzyme activities (SOD, catalase) and attenuates apoptosis triggered by oxidative or chemical stress factors in immune cell cultures.<\/li>\n<li><strong>Pre-formulated Format for Precise Laboratory Dispensing:<\/strong> The stabilized liquid formulation within a 3 ml cartridge eliminates manual dilution variability, ensuring exceptional homogeneity and concentration consistency for automated and semi-automated micro-dispensing systems.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Thymic Bioregulatory Peptide \/ Immunological Standard \/ Research Peptide Solution (RUO)<\/li>\n<li><strong>Product Format:<\/strong> Pre-filled calibrated laboratory cartridge (3 ml volume)<\/li>\n<li><strong>Compound Strength:<\/strong> 10 mg \/ 3 ml (approx. 3.33 mg\/ml concentration)<\/li>\n<li><strong>Amino Acid Sequence:<\/strong> Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH<\/li>\n<li><strong>Molecular Formula:<\/strong><\/li>\n<li><strong>Molecular Weight:<\/strong><\/li>\n<li><strong>Form:<\/strong> Sterile stabilized solution \/ Ready-to-Use (RTU)<\/li>\n<li><strong>Solution Matrix:<\/strong> Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)<\/li>\n<li><strong>Compatibility:<\/strong> Compatible with standard laboratory dispensing pens and micro-dispensers for 3 ml cartridges (<strong>dispensing pen\/injector is not included in the package<\/strong>)<\/li>\n<li><strong>Storage Conditions:<\/strong> Store at 2\u20138 \u00b0C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><em>Goldstein, A. L., &amp; Badamchian, M.<\/em> Thymosins: Chemistry and biological actions in cellular immune systems in vitro. <em>Annals of the New York Academy of Sciences<\/em>, 2004.<\/li>\n<li><em>Romani, L., et al.<\/em> Thymosin alpha1 activates dendritic cells for antifungal Th1 resistance through Toll-like receptor signaling in vitro. <em>Blood<\/em>, 2004.<\/li>\n<li><em>Serafino, A., et al.<\/em> Thymosin alpha1 restores cellular homeostasis and immune function by down-regulating cell-stress signaling pathways. <em>International Immunopharmacology<\/em>, 2012.<\/li>\n<li><em>Garaci, E., et al.<\/em> Thymosin alpha 1: From bench to bedside with special focus on in vitro molecular mechanisms. <em>Expert Opinion on Biological Therapy<\/em>, 2015.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. The stabilized peptide solution and mechanical cartridge are not drugs, medicines, weight-loss agents, dietary supplements, or cosmetic products, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product or medical device. It is not intended for direct consumption, administration, diagnosis, or therapeutic use in humans or animals.<\/li>\n<li><strong>Form &amp; Presentation:<\/strong> The research compound is supplied in a sealed laboratory glass cartridge for precise dispensing within laboratory equipment and analytical systems.<\/li>\n<li><strong>Recommended Storage:<\/strong> Store upright in a cool, dry, and dark environment at 2\u20138 \u00b0C. Protect from freezing and direct light exposure.<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. Structural details of the cartridge, plunger\/cap coloration, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":71,"template":"","meta":[],"product_brand":[],"product_cat":[48],"product_tag":[],"class_list":["post-101","product","type-product","status-publish","has-post-thumbnail","product_cat-laboratory-cartridges","first","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Thymosin Alpha 1 10mg - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Thymosin Alpha 1 10mg - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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