{"id":13010,"date":"2026-10-08T08:21:54","date_gmt":"2026-10-08T08:21:54","guid":{"rendered":"https:\/\/nextrabiochem.eu\/?post_type=product&#038;p=13010"},"modified":"2026-10-13T10:17:57","modified_gmt":"2026-10-13T10:17:57","slug":"humanin-10mg","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/humanin-10mg\/","title":{"rendered":"Humanin 10mg"},"content":{"rendered":"<p><strong>Humanin \u2013 Lyophilized Peptide for In Vitro Research (10 mg)<\/strong> Synthetic mitochondrially-encoded peptide factor (16 amino acids) in the form of a high-purity lyophilisate for in vitro research on cytoprotective mechanisms, apoptosis inhibition, cellular stress regulation, mitochondrial integrity, and longevity-associated signaling.<\/p>\n<p><strong>Overview and Mechanism of Action (In Vitro)<\/strong> Humanin is a bioactive peptide derived from the mitochondrial genome (from the 12S rRNA reading frame). In cell biology, neurobiology, and aging research, it serves as a key reference substance for studying cellular protection and survival signaling pathways:<\/p>\n<ul>\n<li><strong>Neuroprotection and apoptosis inhibition in vitro:<\/strong> Blocks cell death induced by various cytotoxic agents and amyloid peptides in neural and epithelial cell cultures through interaction with specific membrane receptors (including the heterotrimeric receptor complex containing CNTFR\/WSX-1\/gp130).<\/li>\n<li><strong>Regulation of mitochondrial integrity and oxidative stress:<\/strong> Modulates the production of reactive oxygen species (ROS), stabilizes mitochondrial membrane potential, and suppresses cytochrome c release during oxidative stress.<\/li>\n<li><strong>Modulation of insulin signaling and metabolic stress:<\/strong> Influences insulin sensitivity and glucose homeostasis in model cultures in vitro through the activation of pro-survival kinase cascades (e.g., PI3K\/Akt).<\/li>\n<li><strong>Lyophilized format for maximum stability:<\/strong> The product is supplied as a stable lyophilized powder (lyophilisate), ensuring long-term stability of the substance prior to reconstitution and allowing flexible preparation of working solutions with the required concentration for specific laboratory protocols.<\/li>\n<\/ul>\n<p><strong>Technical and Chemical Specification<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Mitochondrial cytoprotective peptide \/ Longevity peptide factor \/ Research peptide (RUO)<\/li>\n<li><strong>Product format:<\/strong> Lyophilized powder in a glass vial<\/li>\n<li><strong>Substance content:<\/strong> 10 mg of pure lyophilisate per vial<\/li>\n<li><strong>Amino acid sequence:<\/strong> Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Ile-Val-Leu-Lys-Val-Glu-Leu (or specific analog modifications for enhanced in vitro stability, e.g., S14G)<\/li>\n<li><strong>Form:<\/strong> Lyophilized powder \/ highly purified substructure intended for reconstitution under laboratory conditions<\/li>\n<li><strong>Recommended reconstitution:<\/strong> For in vitro use, reconstitute in a sterile buffered solution (e.g., PBS) or sterile deionized water for laboratories according to the specific protocol.<\/li>\n<li><strong>Storage conditions:<\/strong> Store lyophilized powder at \u201320 \u00b0C (short-term at 2\u20138 \u00b0C in a dark and dry place). Protect from moisture and freezing. After reconstitution, keep refrigerated and consume according to laboratory standards.<\/li>\n<\/ul>\n<p><strong>Professional Sources and Literature<\/strong><\/p>\n<ul>\n<li>Hashimoto, Y., et al. Humanin, a novel peptide encoded in the mitochondrial genome, prevents neurotoxicity. Proceedings of the National Academy of Sciences (PNAS), 2001.<\/li>\n<li>Muzumdar, R., et al. Humanin: a novel mitochondrial peptide acting on survival and longevity pathways. Journal of Bioenergetics and Biomembranes, 2009.<\/li>\n<li>Yen, K., et al. The mitochondrial derived peptide Humanin: a new mediator of stress and metabolic homeostasis. Molecular and Cellular Endocrinology, 2013.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer and Terms of Purchase<\/strong> This product is classified and supplied exclusively for laboratory, scientific, and in vitro research purposes (Research Use Only \u2013 RUO). The lyophilized peptide is not a medicinal product, drug, weight-loss preparation, dietary supplement, or substance intended for human or veterinary consumption, oral ingestion, injection, or diagnostic procedures. By submitting an order, the buyer explicitly confirms that they have reached the age of at least 18 years, possess adequate laboratory infrastructure and personnel equipment for safe handling of research chemicals, and are fully familiar with laboratory safety protocols. The seller assumes no liability for any improper or unapproved use.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.<\/li>\n<li><strong>Form &amp; Contents:<\/strong> Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.<\/li>\n<li><strong>Recommended Storage:<\/strong> To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":13009,"template":"","meta":[],"product_brand":[],"product_cat":[47],"product_tag":[],"class_list":["post-13010","product","type-product","status-publish","has-post-thumbnail","product_cat-lyophilized-compounds","first","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Humanin 10mg - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nextrabiochem.eu\/produkt\/humanin-10mg\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Humanin 10mg - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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