{"id":1427,"date":"2026-09-11T08:58:42","date_gmt":"2026-09-11T08:58:42","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/tb-500\/"},"modified":"2026-09-11T12:15:53","modified_gmt":"2026-09-11T12:15:53","slug":"tb-500","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/tb-500\/","title":{"rendered":"TB-500"},"content":{"rendered":"<p><strong>TB-500<\/strong><\/p>\n<p><i>Synthetic thymosin <\/i>\u03b24<i> analog (containing the active LKKTET motif) for in vitro research on actin sequestration, cell motility, angiogenesis, and repair pathways<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>TB-500<\/strong> is a synthetic peptide structurally derived from the naturally occurring 43-amino acid protein thymosin \u03b24 (T\u03b24). In cellular biology, regenerative medicine, and tissue engineering, it serves as a primary research model for investigating cytoskeletal remodeling and intercellular repair cascades:<\/p>\n<ul>\n<li><strong>G-Actin Sequestration &amp; Cytoskeletal Regulation:<\/strong> Utilizes its highly conserved active hexapeptide binding motif (<i>LKKTET<\/i>) to bind monomeric globular actin (G-actin) in a 1:1 stoichiometry. It inhibits premature polymerization into F-actin, maintains a functional pool of actin monomers, and facilitates the dynamic cytoskeletal reorganization required for cellular motility.<\/li>\n<li><strong>Stimulation of Directed Cell Migration:<\/strong> Significantly enhances motility, lamellipodia protrusion, and directional migration in endothelial cells, dermal fibroblasts, and epithelial cells within experimental wound-healing models (<i>scratch assays<\/i>).<\/li>\n<li><strong>Angiogenesis &amp; Endothelial Morphogenesis:<\/strong> Induces capillary-like tube formation and activates vascular endothelial growth factor (VEGF) signaling pathways in isolated endothelial culture systems.<\/li>\n<li><strong>Modulation of Inflammation &amp; ECM Dynamics:<\/strong> Suppresses NF-\u03baB nuclear translocation, downregulates pro-inflammatory mediators, and modulates collagen deposition profiles to explore the prevention of fibrotic tissue formation in vitro.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Research Peptide \/ Tissue Repair &amp; Actin-Sequestering Factor<\/li>\n<li><strong>Amino Acid Sequence:<\/strong> Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser<\/li>\n<li><strong>Form:<\/strong> Sterile lyophilized white powder (cake)<\/li>\n<li><strong>Molecular Weight Identification:<\/strong> Confirmed via Mass Spectrometry (MS)<\/li>\n<li><strong>Recommended Reconstitution Solvent:<\/strong> Sterile bacteriostatic water or phosphate-buffered saline (PBS)<\/li>\n<li><strong>Storage Conditions:<\/strong> Store long-term at -20 \u00b0C in a dry, dark environment. Following reconstitution, keep refrigerated at 2\u20138 \u00b0C and utilize within standard experimental protocol timelines.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Goldstein, A. L., et al.<\/i> Thymosin beta 4: Actin-sequestering protein and its multifaceted roles in cellular motility and tissue repair. <i>Annals of the New York Academy of Sciences<\/i>, 2007.<\/li>\n<li><i>Philp, D., et al.<\/i> The actin-binding site of thymosin beta 4 promotes cell migration and accelerates wound healing in experimental models. <i>FASEB Journal<\/i>, 2003.<\/li>\n<li><i>Huff, T., et al.<\/i> Thymosin beta 4: Molecular biology, structural properties, and actin-binding mechanisms. <i>The International Journal of Biochemistry &amp; Cell Biology<\/i>, 2001.<\/li>\n<li><i>Malinda, K. M., et al.<\/i> Thymosin beta 4 accelerates wound healing and promotes endothelial cell migration and tube formation in vitro. <i>Journal of Investigative Dermatology<\/i>, 1999.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.<\/li>\n<li><strong>Form &amp; Contents:<\/strong> Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.<\/li>\n<li><strong>Recommended Storage:<\/strong> To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":1428,"template":"","meta":[],"product_brand":[],"product_cat":[47],"product_tag":[],"class_list":["post-1427","product","type-product","status-publish","has-post-thumbnail","product_cat-lyophilized-compounds","pa_obsah-10mg","pa_obsah-5mg","first","instock","purchasable","product-type-variable","has-default-attributes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>TB-500 - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"TB-500 - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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