{"id":1507,"date":"2026-09-11T08:58:37","date_gmt":"2026-09-11T08:58:37","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/igf1-lr3\/"},"modified":"2026-09-11T12:15:56","modified_gmt":"2026-09-11T12:15:56","slug":"igf1-lr3","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/igf1-lr3\/","title":{"rendered":"IGF1 LR3"},"content":{"rendered":"<p><strong>IGF-1 LR3<\/strong><\/p>\n<p><i>Recombinant analogue of human insulin-like growth factor-1 with an N-terminal extension and Arg3 substitution for in vitro research on IGF-1R activation, mitogenesis, protein synthesis, and PI3K\/Akt\/mTOR signaling pathways<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>IGF-1 LR3<\/strong> (<i>Long <\/i>Arg3<i> Insulin-like Growth Factor-1<\/i>) is a synthetic recombinant analogue of native human IGF-1 consisting of 83 amino acids. It features a glutamic acid to arginine substitution at position 3 (Glu3\u2192Arg3) alongside a 13-amino acid N-terminal extension peptide sequence. These structural modifications drastically decrease affinity for inhibitory insulin-like growth factor-binding proteins (IGFBPs), ensuring significantly elevated free peptide availability for receptor interaction and extending its biological half-life in culture media. In cellular biology, tissue engineering, and oncology models, it serves as a primary reference for investigating growth factor cascades:<\/p>\n<ul>\n<li><strong>Elevated Free Bioavailability &amp; IGFBP Resistance:<\/strong> Marked reduction in affinity for regulatory proteins IGFBP-1 through IGFBP-6, preventing rapid neutralization and ensuring sustained receptor access in vitro.<\/li>\n<li><strong>IGF-1R Receptor Activation &amp; Transphosphorylation:<\/strong> Binding to the receptor tyrosine kinase (IGF-1R) induces cytoplasmic auto-phosphorylation and downstream recruitment of insulin receptor substrates (IRS-1, IRS-2).<\/li>\n<li><strong>Upregulation of the PI3K \/ Akt \/ mTOR Pathway:<\/strong> Stimulation of anabolic signaling cascades promoting p70S6 kinase phosphorylation, mRNA translation initiation, cellular protein synthesis, and attenuation of the ubiquitin-proteasome proteolytic machinery.<\/li>\n<li><strong>Mitogenic Progression via MAPK \/ ERK Signaling:<\/strong> Induction of cell cycle transition from the G1 to S phase, activation of myoblast proliferation, and suppression of apoptotic cascades in primary cell lines.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Research Peptide \/ Extended-Action IGF-1 Analogue (Long Arg3-IGF-1)<\/li>\n<li><strong>Amino Acid Sequence:<\/strong> 83-amino acid recombinant polypeptide with 3 intramolecular disulfide bonds<\/li>\n<li><strong>Form:<\/strong> Sterile lyophilized white powder (cake)<\/li>\n<li><strong>Component Identification:<\/strong> Verified via Mass Spectrometry (MS) and analytical HPLC<\/li>\n<li><strong>Recommended Reconstitution Solvent:<\/strong> Sterile 10mM\u2013100mM acetic acid solution, sterile bacteriostatic water, or sterile phosphate-buffered saline (PBS)<\/li>\n<li><strong>Storage Conditions:<\/strong> Store long-term at -20 \u00b0C in a dry, dark environment. Following reconstitution, keep refrigerated at 2\u20138 \u00b0C in accordance with standard laboratory protocols.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Francis, G. L., et al.<\/i> Novel recombinant analogues of insulin-like growth factor-1 (IGF-1) with altered affinities for IGF-binding proteins. <i>Biochemical Journal<\/i>, 1992.<\/li>\n<li><i>Tomas, F. M., et al.<\/i> Greater potency of IGF-I analogues than IGF-I in catabolic states is associated with altered binding to IGF-binding proteins. <i>Journal of Endocrinology<\/i>, 1995.<\/li>\n<li><i>Clemmons, D. R.<\/i> Role of insulin-like growth factor binding proteins in controlling IGF actions in target cells. <i>Endocrine Reviews<\/i>, 1997.<\/li>\n<li><i>Ballard, F. J., et al.<\/i> Biological actions and structural characteristics of Long Arg3-IGF-1 in cell culture and experimental systems. <i>Regulatory Peptides<\/i>, 1996.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.<\/li>\n<li><strong>Form &amp; Contents:<\/strong> Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.<\/li>\n<li><strong>Recommended Storage:<\/strong> To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":2334,"template":"","meta":[],"product_brand":[],"product_cat":[47],"product_tag":[],"class_list":["post-1507","product","type-product","status-publish","has-post-thumbnail","product_cat-lyophilized-compounds","pa_obsah-01mg","pa_obsah-1mg","first","instock","purchasable","product-type-variable","has-default-attributes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IGF1 LR3 - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IGF1 LR3 - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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