{"id":1603,"date":"2026-09-11T08:58:37","date_gmt":"2026-09-11T08:58:37","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/selank\/"},"modified":"2026-09-11T12:15:59","modified_gmt":"2026-09-11T12:15:59","slug":"selank","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/selank\/","title":{"rendered":"Selank"},"content":{"rendered":"<p><strong>Selank<\/strong><\/p>\n<p><i>Synthetic regulatory heptapeptide derived from tuftsin for in vitro research on GABAergic modulation, neurotrophin expression (BDNF), and neuroimmune pathways<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>Selank<\/strong> (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide developed by modifying the endogenous immunopeptide tuftsin (Thr-Lys-Pro-Arg) through the addition of a C-terminal Pro-Gly-Pro tripeptide sequence to significantly enhance metabolic and enzymatic stability. In neurobiological, neuropharmacological, and immunological research, it serves as a primary reference model for investigating anxiolytic, neuroprotective, and neuromodulatory signaling:<\/p>\n<ul>\n<li><strong>Modulation of GABAergic Neurotransmission:<\/strong> Allosteric modulation of GABAA receptor complexes and regulation of GABA binding affinity in neuronal membrane preparations without non-specific sedative or myorelaxant profiles.<\/li>\n<li><strong>Upregulation of Neurotrophic Factors (BDNF, NGF):<\/strong> Induction of gene expression and release of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in hippocampal and cortical neuronal cultures.<\/li>\n<li><strong>Monoaminergic System Interaction:<\/strong> Modulation of turnover rates and metabolic cascades of serotonin (5-HT), dopamine, and norepinephrine across designated brain regions and synaptosomal models.<\/li>\n<li><strong>Neuroimmunomodulation &amp; Cytokine Balance:<\/strong> Regulation of pro- and anti-inflammatory cytokine expression profiles (IL-6, TNF-\u03b1, IL-10) and modulation of signaling networks linked to T-lymphocyte function.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Research Peptide \/ Stabilized Tuftsin Analogue<\/li>\n<li><strong>Amino Acid Sequence:<\/strong> Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)<\/li>\n<li><strong>Form:<\/strong> Sterile lyophilized white powder (cake)<\/li>\n<li><strong>Component Identification:<\/strong> Verified via Mass Spectrometry (MS) and analytical HPLC<\/li>\n<li><strong>Recommended Reconstitution Solvent:<\/strong> Sterile bacteriostatic water or sterile phosphate-buffered saline (PBS)<\/li>\n<li><strong>Storage Conditions:<\/strong> Store long-term at -20 \u00b0C in a dry, dark environment. Following reconstitution, keep refrigerated at 2\u20138 \u00b0C and utilize within standard experimental protocol timelines.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Ashmarin, I. P., et al.<\/i> Selank, anxiolytic heptapeptide: Neurochemical and behavioral properties in experimental models. <i>Russian Journal of Physiology<\/i>, 2005.<\/li>\n<li><i>Uchitel, I. A., et al.<\/i> The effect of the synthetic peptide Selank on the expression of BDNF and its receptor TrkB in the rat hippocampus. <i>Bulletin of Experimental Biology and Medicine<\/i>, 2010.<\/li>\n<li><i>Semenova, T. P., et al.<\/i> The influence of Selank on the functional state of the serotonin and dopamine systems in brain tissue. <i>Neurochemical Journal<\/i>, 2008.<\/li>\n<li><i>Ershov, F. I., et al.<\/i> Antiviral and immunomodulatory activity of Selank in viral infections and cellular models. <i>Voprosy Virusologii<\/i>, 2009.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.<\/li>\n<li><strong>Form &amp; Contents:<\/strong> Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.<\/li>\n<li><strong>Recommended Storage:<\/strong> To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":1604,"template":"","meta":[],"product_brand":[],"product_cat":[47],"product_tag":[],"class_list":["post-1603","product","type-product","status-publish","has-post-thumbnail","product_cat-lyophilized-compounds","pa_obsah-10mg","pa_obsah-5mg","first","instock","purchasable","product-type-variable","has-default-attributes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Selank - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Selank - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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