{"id":1663,"date":"2026-09-11T08:58:33","date_gmt":"2026-09-11T08:58:33","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/cjc-1295-no-dac\/"},"modified":"2026-09-11T12:15:59","modified_gmt":"2026-09-11T12:15:59","slug":"cjc-1295-no-dac","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/cjc-1295-no-dac\/","title":{"rendered":"CJC-1295 no DAC"},"content":{"rendered":"<p><strong>CJC-1295 no DAC<\/strong><\/p>\n<p><i>Synthetic tetra-substituted GHRH(1\u201329) analog for in vitro research on pulsatile receptor signaling<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>CJC-1295 no DAC<\/strong> (also recognized as <i>Modified GRF 1-29<\/i> or <i>Mod GRF 1-29<\/i>) is a synthetic peptide consisting of 29 amino acids. It represents an optimized analog of natural growth hormone-releasing hormone (GHRH). In laboratory settings, it serves as a reference model for studying physiologically mimicked, pulsatile activation of receptor pathways:<\/p>\n<ul>\n<li><strong>Selective GHRH Receptor (GHRH-R) Binding:<\/strong> Specific binding to Gs-protein coupled receptors on isolated pituitary cells, promoting adenylate cyclase stimulation, intracellular cAMP elevation, and downstream PKA signaling pathway activation.<\/li>\n<li><strong>Tetra-Substituted Sequence Stabilization:<\/strong> Targeted replacement of four amino acid residues at positions 2, 8, 15, and 27 (<i>[D-Ala2, Gln8, Ala15, Leu27]-GHRH(1-29)<\/i>) confers significant resistance to enzymatic cleavage by dipeptidyl peptidase-4 (DPP-4) and other serum endopeptidases.<\/li>\n<li><strong>Pulsatile Kinetic Profile:<\/strong> Unlike the DAC-conjugated variant, it lacks the maleimidopropionic acid moiety and does not form covalent adducts with albumin. In experimental models, this shorter biological half-life facilitates accurate simulation of natural pulsatile secretagogue cycles without inducing continuous receptor saturation.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Research Peptide \/ Modified GHRH Fragment (GHRH-R Agonist)<\/li>\n<li><strong>Amino Acid Sequence:<\/strong> Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2<\/li>\n<li><strong>Form:<\/strong> Sterile lyophilized white powder (cake)<\/li>\n<li><strong>Molecular Weight Identification:<\/strong> Confirmed via Mass Spectrometry (MS)<\/li>\n<li><strong>Recommended Reconstitution Solvent:<\/strong> Sterile bacteriostatic water or phosphate-buffered saline (PBS)<\/li>\n<li><strong>Storage Conditions:<\/strong> Store long-term at -20 \u00b0C in a dry, dark environment. Following reconstitution, keep refrigerated at 2\u20138 \u00b0C and utilize within standard experimental protocol timelines.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Campbell, R. M., et al.<\/i> Enhanced stability and biological activity of synthetic GHRH analogs containing D-amino acid substitutions. <i>Peptides<\/i>, 1997.<\/li>\n<li><i>Jette, L., et al.<\/i> Structural optimization of GHRH(1-29) analogs: Comparative analysis of enzyme resistance and receptor affinity in vitro. <i>Endocrinology<\/i>, 2005.<\/li>\n<li><i>Frohman, L. A., et al.<\/i> Dipeptidyl peptidase IV cleavage of growth hormone-releasing hormone in model biological fluids. <i>Journal of Clinical Investigation<\/i>, 1989.<\/li>\n<li><i>Sackmann-Sala, L., et al.<\/i> GHRH receptor activation kinetics and downstream transcriptional responses in cultured somatotropes. <i>Growth Hormone &amp; IGF Research<\/i>, 2009.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.<\/li>\n<li><strong>Form &amp; Contents:<\/strong> Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.<\/li>\n<li><strong>Recommended Storage:<\/strong> To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":1664,"template":"","meta":[],"product_brand":[],"product_cat":[47],"product_tag":[],"class_list":["post-1663","product","type-product","status-publish","has-post-thumbnail","product_cat-lyophilized-compounds","pa_obsah-10mg","pa_obsah-5mg","first","instock","purchasable","product-type-variable","has-default-attributes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CJC-1295 no DAC - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CJC-1295 no DAC - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.  Form &amp; Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.  Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).  Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nextrabiochem.eu\/en\/produkt\/cjc-1295-no-dac\/\" \/>\n<meta property=\"og:site_name\" content=\"Nextrabiochem.eu\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-11T12:15:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/CJC-n-DAC-5.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/cjc-1295-no-dac\\\/\",\"url\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/cjc-1295-no-dac\\\/\",\"name\":\"CJC-1295 no DAC - Nextrabiochem.eu\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/cjc-1295-no-dac\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/cjc-1295-no-dac\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/nextrabiochem.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/CJC-n-DAC-5.jpg\",\"datePublished\":\"2026-09-11T08:58:33+00:00\",\"dateModified\":\"2026-09-11T12:15:59+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/cjc-1295-no-dac\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/cjc-1295-no-dac\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/cjc-1295-no-dac\\\/#primaryimage\",\"url\":\"https:\\\/\\\/nextrabiochem.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/CJC-n-DAC-5.jpg\",\"contentUrl\":\"https:\\\/\\\/nextrabiochem.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/CJC-n-DAC-5.jpg\",\"width\":1024,\"height\":1024},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/cjc-1295-no-dac\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Dom\u016f\",\"item\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Shop\",\"item\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/shop\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"CJC-1295 no DAC\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#website\",\"url\":\"https:\\\/\\\/nextrabiochem.eu\\\/\",\"name\":\"Nextrabiochem\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/nextrabiochem.eu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#organization\",\"name\":\"MALAM \u2013 PAGI \u2013 SORE LTD\",\"url\":\"https:\\\/\\\/nextrabiochem.eu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/nextrabiochem.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/logo-transparent.png\",\"contentUrl\":\"https:\\\/\\\/nextrabiochem.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/logo-transparent.png\",\"width\":1942,\"height\":809,\"caption\":\"MALAM \u2013 PAGI \u2013 SORE LTD\"},\"image\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"CJC-1295 no DAC - Nextrabiochem.eu","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"CJC-1295 no DAC - Nextrabiochem.eu","og_description":"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.  Form &amp; Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.  Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).  Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.","og_url":"https:\/\/nextrabiochem.eu\/en\/produkt\/cjc-1295-no-dac\/","og_site_name":"Nextrabiochem.eu","article_modified_time":"2026-09-11T12:15:59+00:00","og_image":[{"width":1024,"height":1024,"url":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/CJC-n-DAC-5.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/cjc-1295-no-dac\/","url":"https:\/\/nextrabiochem.eu\/en\/produkt\/cjc-1295-no-dac\/","name":"CJC-1295 no DAC - Nextrabiochem.eu","isPartOf":{"@id":"https:\/\/nextrabiochem.eu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/cjc-1295-no-dac\/#primaryimage"},"image":{"@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/cjc-1295-no-dac\/#primaryimage"},"thumbnailUrl":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/CJC-n-DAC-5.jpg","datePublished":"2026-09-11T08:58:33+00:00","dateModified":"2026-09-11T12:15:59+00:00","breadcrumb":{"@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/cjc-1295-no-dac\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/nextrabiochem.eu\/en\/produkt\/cjc-1295-no-dac\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/cjc-1295-no-dac\/#primaryimage","url":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/CJC-n-DAC-5.jpg","contentUrl":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/CJC-n-DAC-5.jpg","width":1024,"height":1024},{"@type":"BreadcrumbList","@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/cjc-1295-no-dac\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Dom\u016f","item":"https:\/\/nextrabiochem.eu\/en\/"},{"@type":"ListItem","position":2,"name":"Shop","item":"https:\/\/nextrabiochem.eu\/en\/shop\/"},{"@type":"ListItem","position":3,"name":"CJC-1295 no DAC"}]},{"@type":"WebSite","@id":"https:\/\/nextrabiochem.eu\/#website","url":"https:\/\/nextrabiochem.eu\/","name":"Nextrabiochem","description":"","publisher":{"@id":"https:\/\/nextrabiochem.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/nextrabiochem.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/nextrabiochem.eu\/#organization","name":"MALAM \u2013 PAGI \u2013 SORE LTD","url":"https:\/\/nextrabiochem.eu\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nextrabiochem.eu\/#\/schema\/logo\/image\/","url":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/logo-transparent.png","contentUrl":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/logo-transparent.png","width":1942,"height":809,"caption":"MALAM \u2013 PAGI \u2013 SORE LTD"},"image":{"@id":"https:\/\/nextrabiochem.eu\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/product\/1663","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/media\/1664"}],"wp:attachment":[{"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/media?parent=1663"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/product_brand?post=1663"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/product_cat?post=1663"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/product_tag?post=1663"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}