{"id":1776,"date":"2026-09-11T08:15:57","date_gmt":"2026-09-11T08:15:57","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/pinealon-10mg\/"},"modified":"2026-09-11T12:16:02","modified_gmt":"2026-09-11T12:16:02","slug":"pinealon-10mg","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/pinealon-10mg\/","title":{"rendered":"Pinealon 10mg"},"content":{"rendered":"<p><strong>Pinealon<\/strong><\/p>\n<p><i>Synthetic bioactive tripeptide (Glu-Asp-Arg) for in vitro research on neuroprotection, neuronal gene expression regulation, cognitive pathway modulation, and suppression of apoptosis<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>Pinealon<\/strong> is a synthetic ultra-short peptide (tripeptide) composed of three amino acids with the sequence <i>(Glu-Asp-Arg \/ EDR)<\/i>, originally designed based on bioactive peptide extracts from brain tissue and the pineal gland. It is characterized by high bioavailability, direct cellular and nuclear membrane permeability, and site-specific interactions with DNA. In molecular neurobiology, biogerontology, and neuropharmacology, it serves as a primary model for investigating neuronal stability and epigenetic regulation in the CNS:<\/p>\n<ul>\n<li><strong>Direct Epigenetic Interaction with DNA:<\/strong> Site-specific binding to nucleotide sequences in the major and minor grooves of DNA in neuronal nuclei, inducing chromatin decondensation and modulating neurospecific gene expression programs.<\/li>\n<li><strong>Suppression of Neuronal Apoptosis &amp; Oxidative Stress:<\/strong> Downregulation of the pro-apoptotic factor Bax, maintenance of anti-apoptotic Bcl-2 expression, and inhibition of caspase-3 activation under hypoxic and excitotoxic stress conditions.<\/li>\n<li><strong>Upregulation of Neurotrophic Factors &amp; Synaptogenesis:<\/strong> Stimulation of neurotrophin expression (including BDNF and NGF) and preservation of essential synaptic scaffold proteins (synaptophysin, PSD-95) supporting synaptic plasticity in vitro.<\/li>\n<li><strong>Mitochondrial Protection &amp; Bioenergetics:<\/strong> Preservation of inner mitochondrial membrane potential (\u0394\u03a8m) and cellular ATP generation in cortical neurons and glial cells challenged with reactive oxygen species (ROS).<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Research Tripeptide \/ Neuroprotective &amp; Epigenetic Regulator<\/li>\n<li><strong>Amino Acid Sequence:<\/strong> Glu-Asp-Arg (EDR)<\/li>\n<li><strong>Form:<\/strong> Sterile lyophilized white powder (cake)<\/li>\n<li><strong>Component Identification:<\/strong> Verified via Mass Spectrometry (MS) and analytical HPLC<\/li>\n<li><strong>Recommended Reconstitution Solvent:<\/strong> Sterile bacteriostatic water or sterile phosphate-buffered saline (PBS)<\/li>\n<li><strong>Storage Conditions:<\/strong> Store long-term at -20 \u00b0C in a dry, dark environment. Following reconstitution, keep refrigerated at 2\u20138 \u00b0C in accordance with standard laboratory protocols.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Khavinson, V. K., et al.<\/i> Peptides regulate gene expression in human cortical neuronal cultures during aging and neurodegeneration. <i>Neurochemistry International<\/i>, 2017.<\/li>\n<li><i>Khavinson, V. K., et al.<\/i> Pinealon protects neurons against oxidative stress and modulates caspase cascades in experimental models. <i>Bulletin of Experimental Biology and Medicine<\/i>, 2011.<\/li>\n<li><i>Korkushko, O. V., et al.<\/i> Peptide geroprotectors from brain tissue and pineal gland: Modulation of cognitive functions and neuroprotection. <i>Biogerontology<\/i>, 2014.<\/li>\n<li><i>Menzikov, S. A., et al.<\/i> Protective effect of the tripeptide Glu-Asp-Arg (Pinealon) on cell survival and mitochondrial potential during simulated ischemic stress. <i>Cell Tissue Biology<\/i>, 2016.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.<\/li>\n<li><strong>Form &amp; Contents:<\/strong> Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.<\/li>\n<li><strong>Recommended Storage:<\/strong> To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":1777,"template":"","meta":[],"product_brand":[],"product_cat":[47],"product_tag":[],"class_list":["post-1776","product","type-product","status-publish","has-post-thumbnail","product_cat-lyophilized-compounds","first","instock","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pinealon 10mg - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pinealon 10mg - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.  Form &amp; Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.  Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).  Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nextrabiochem.eu\/en\/produkt\/pinealon-10mg\/\" \/>\n<meta property=\"og:site_name\" content=\"Nextrabiochem.eu\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-11T12:16:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/Pinealon-10.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/pinealon-10mg\\\/\",\"url\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/pinealon-10mg\\\/\",\"name\":\"Pinealon 10mg - Nextrabiochem.eu\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/pinealon-10mg\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/pinealon-10mg\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/nextrabiochem.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/Pinealon-10.jpg\",\"datePublished\":\"2026-09-11T08:15:57+00:00\",\"dateModified\":\"2026-09-11T12:16:02+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/pinealon-10mg\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/pinealon-10mg\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/pinealon-10mg\\\/#primaryimage\",\"url\":\"https:\\\/\\\/nextrabiochem.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/Pinealon-10.jpg\",\"contentUrl\":\"https:\\\/\\\/nextrabiochem.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/Pinealon-10.jpg\",\"width\":1024,\"height\":1024},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/pinealon-10mg\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Dom\u016f\",\"item\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Shop\",\"item\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/shop\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Pinealon 10mg\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#website\",\"url\":\"https:\\\/\\\/nextrabiochem.eu\\\/\",\"name\":\"Nextrabiochem\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/nextrabiochem.eu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#organization\",\"name\":\"MALAM \u2013 PAGI \u2013 SORE LTD\",\"url\":\"https:\\\/\\\/nextrabiochem.eu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/nextrabiochem.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/logo-transparent.png\",\"contentUrl\":\"https:\\\/\\\/nextrabiochem.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/logo-transparent.png\",\"width\":1942,\"height\":809,\"caption\":\"MALAM \u2013 PAGI \u2013 SORE LTD\"},\"image\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Pinealon 10mg - Nextrabiochem.eu","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"Pinealon 10mg - Nextrabiochem.eu","og_description":"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.  Form &amp; Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.  Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).  Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.","og_url":"https:\/\/nextrabiochem.eu\/en\/produkt\/pinealon-10mg\/","og_site_name":"Nextrabiochem.eu","article_modified_time":"2026-09-11T12:16:02+00:00","og_image":[{"width":1024,"height":1024,"url":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/Pinealon-10.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/pinealon-10mg\/","url":"https:\/\/nextrabiochem.eu\/en\/produkt\/pinealon-10mg\/","name":"Pinealon 10mg - Nextrabiochem.eu","isPartOf":{"@id":"https:\/\/nextrabiochem.eu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/pinealon-10mg\/#primaryimage"},"image":{"@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/pinealon-10mg\/#primaryimage"},"thumbnailUrl":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/Pinealon-10.jpg","datePublished":"2026-09-11T08:15:57+00:00","dateModified":"2026-09-11T12:16:02+00:00","breadcrumb":{"@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/pinealon-10mg\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/nextrabiochem.eu\/en\/produkt\/pinealon-10mg\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/pinealon-10mg\/#primaryimage","url":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/Pinealon-10.jpg","contentUrl":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/Pinealon-10.jpg","width":1024,"height":1024},{"@type":"BreadcrumbList","@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/pinealon-10mg\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Dom\u016f","item":"https:\/\/nextrabiochem.eu\/en\/"},{"@type":"ListItem","position":2,"name":"Shop","item":"https:\/\/nextrabiochem.eu\/en\/shop\/"},{"@type":"ListItem","position":3,"name":"Pinealon 10mg"}]},{"@type":"WebSite","@id":"https:\/\/nextrabiochem.eu\/#website","url":"https:\/\/nextrabiochem.eu\/","name":"Nextrabiochem","description":"","publisher":{"@id":"https:\/\/nextrabiochem.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/nextrabiochem.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/nextrabiochem.eu\/#organization","name":"MALAM \u2013 PAGI \u2013 SORE LTD","url":"https:\/\/nextrabiochem.eu\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nextrabiochem.eu\/#\/schema\/logo\/image\/","url":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/logo-transparent.png","contentUrl":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/logo-transparent.png","width":1942,"height":809,"caption":"MALAM \u2013 PAGI \u2013 SORE LTD"},"image":{"@id":"https:\/\/nextrabiochem.eu\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/product\/1776","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/media\/1777"}],"wp:attachment":[{"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/media?parent=1776"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/product_brand?post=1776"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/product_cat?post=1776"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/product_tag?post=1776"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}