{"id":1808,"date":"2026-09-11T08:15:57","date_gmt":"2026-09-11T08:15:57","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/snap-8-10mg\/"},"modified":"2026-09-11T12:16:02","modified_gmt":"2026-09-11T12:16:02","slug":"snap-8-10mg","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/snap-8-10mg\/","title":{"rendered":"Snap-8 10mg"},"content":{"rendered":"<p><strong>SNAP-8<\/strong><\/p>\n<p><i>Synthetic octapeptide analogue of the SNAP-25 N-terminus (acetyl octapeptide-3) for in vitro research on SNARE complex competitive inhibition, acetylcholine exocytosis modulation, and neuromuscular signaling<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>SNAP-8<\/strong> (chemically designated as <i>Acetyl Octapeptide-3<\/i> or <i>Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-<\/i>NH2) is a synthetic octapeptide designed as an elongated analogue of the hexapeptide Argireline (acetyl hexapeptide-8). It structurally mimics the N-terminal domain of the native synaptosomal-associated protein 25 kDa (SNAP-25). In cellular neurobiology, vesicular transport biophysics, and dermatological research models, it serves as a primary reference standard for investigating neurotransmitter exocytosis modulation:<\/p>\n<ul>\n<li><strong>Competitive Inhibition &amp; SNARE Complex Destabilization:<\/strong> Operates as a biological decoy that competes with native SNAP-25 for binding positions within the ternary SNARE core complex (syntaxin-1, synaptobrevin\/VAMP, and SNAP-25), preventing proper fusion assembly.<\/li>\n<li><strong>Suppression of Vesicular Acetylcholine Release:<\/strong> Disrupting functional SNARE pin formation inhibits the membrane fusion of neurotransmitter vesicles with the presynaptic membrane, significantly attenuating acetylcholine exocytosis in vitro.<\/li>\n<li><strong>Modulation of Neuromuscular Excitability:<\/strong> Investigating attenuation of cellular micro-contractions in motor neuron and myocyte co-culture models without inducing cytotoxicity or permanent synaptic blockade.<\/li>\n<li><strong>Enhanced Potency Relative to Hexapeptide Precursors:<\/strong> Modeling the increased binding affinity and inhibitory kinetics (~30% greater inhibition of exocytosis in vitro) gained from the two additional C-terminal residues compared to classic Argireline.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Research Peptide \/ SNARE Complex Modulator (Acetyl Octapeptide-3)<\/li>\n<li><strong>Amino Acid Sequence:<\/strong> Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2<\/li>\n<li><strong>Form:<\/strong> Sterile lyophilized white powder (cake)<\/li>\n<li><strong>Component Identification:<\/strong> Verified via Mass Spectrometry (MS) and analytical HPLC<\/li>\n<li><strong>Recommended Reconstitution Solvent:<\/strong> Sterile bacteriostatic water or sterile phosphate-buffered saline (PBS)<\/li>\n<li><strong>Storage Conditions:<\/strong> Store long-term at -20 \u00b0C in a dry, dark environment. Following reconstitution, keep refrigerated at 2\u20138 \u00b0C in accordance with standard laboratory protocols.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Blanes-Mira, C., et al.<\/i> A synthetic hexapeptide (Argireline) with antiwrinkle activity: Mechanisms of SNARE complex disruption and neurotransmitter release inhibition. <i>International Journal of Cosmetic Science<\/i>, 2002.<\/li>\n<li><i>Guti\u00e9rrez, L. M., et al.<\/i> A peptide that mimics the C-terminal sequence of SNAP-25 inhibits neurotransmitter exocytosis in chromaffin cells. <i>FEBS Letters<\/i>, 1997.<\/li>\n<li><i>Lupo, M. P., &amp; Cole, A. L.<\/i> Cosmeceutical peptides: SNAP-8 and other active biomimetic fragments targeting facial lines and muscle modulation. <i>Dermatologic Therapy<\/i>, 2007.<\/li>\n<li><i>Gorouhi, F., &amp; Maibach, H. I.<\/i> Role of topical peptides in preventing or treating aged skin: Molecular pathways and SNARE inhibitors. <i>International Journal of Cosmetic Science<\/i>, 2009.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.<\/li>\n<li><strong>Form &amp; Contents:<\/strong> Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.<\/li>\n<li><strong>Recommended Storage:<\/strong> To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":1809,"template":"","meta":[],"product_brand":[],"product_cat":[47],"product_tag":[],"class_list":["post-1808","product","type-product","status-publish","has-post-thumbnail","product_cat-lyophilized-compounds","first","instock","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Snap-8 10mg - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Snap-8 10mg - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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