{"id":1832,"date":"2026-09-11T08:15:57","date_gmt":"2026-09-11T08:15:57","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/vip-5mg\/"},"modified":"2026-09-11T12:16:04","modified_gmt":"2026-09-11T12:16:04","slug":"vip-5mg","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/vip-5mg\/","title":{"rendered":"VIP 5mg"},"content":{"rendered":"<p><strong>VIP (Vasoactive Intestinal Peptide)<\/strong><\/p>\n<p><i>Synthetic bioactive 28-amino-acid neuropeptide amide for in vitro research on VPAC1 and VPAC2 receptor activation, intracellular cAMP\/PKA signaling cascades, macrophage anti-inflammatory polarization, and microvascular relaxation<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>VIP (Vasoactive Intestinal Peptide)<\/strong> is a synthetic biologically active neuropeptide comprising 28 amino acids with C-terminal amidation, belonging to the glucagon-secretin superfamily. It acts as a high-affinity endogenous agonist of G-protein coupled receptors, specifically the <strong>VPAC1<\/strong> and <strong>VPAC2<\/strong> subtypes. In molecular immunology, neurobiology, and cellular physiology, it serves as a primary reference standard for investigating neuro-immune interactions, cytoprotection, and vasorelaxant mechanisms:<\/p>\n<ul>\n<li><strong>Activation of the VPAC1\/2 \u2013 <\/strong>G\u03b1s<strong> \u2013 Adenylyl Cyclase \u2013 cAMP Axis:<\/strong> Selective binding to VPAC1 and VPAC2 receptors stimulates adenylyl cyclase, driving rapid accumulation of intracellular cAMP followed by protein kinase A (PKA) activation and CREB phosphorylation.<\/li>\n<li><strong>Suppression of Pro-Inflammatory Macrophage &amp; Microglial Polarization:<\/strong> Inhibits the nuclear translocation of nuclear factor kappa B (NF-\u03baB), significantly downregulating pro-inflammatory mediators (TNF-\u03b1, IL-1$beta$, IL-6, iNOS) and promoting an M2 anti-inflammatory phenotype in vitro.<\/li>\n<li><strong>Modulation of Smooth Muscle &amp; Endothelial Homeostasis:<\/strong> Upregulates endothelial nitric oxide synthase (eNOS) activity and induces direct relaxation of vascular and bronchial smooth muscle cells via membrane hyperpolarization.<\/li>\n<li><strong>Apoptosis Suppression &amp; Neuronal Survival:<\/strong> Protects neuronal and glial cell cultures from oxidative stress, excitotoxic insults, and cytokine-mediated apoptosis by upregulating neuroprotective factors.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Research Neuropeptide \/ VPAC1 and VPAC2 Receptor Agonist<\/li>\n<li><strong>Amino Acid Sequence:<\/strong> H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2<\/li>\n<li><strong>Molecular Formula:<\/strong> C147H238N44O42S<\/li>\n<li><strong>Molecular Weight:<\/strong> \u22483325.8\u00a0g\/mol<\/li>\n<li><strong>Form:<\/strong> Sterile lyophilized white powder (cake)<\/li>\n<li><strong>Component Identification:<\/strong> Verified via Mass Spectrometry (MS) and analytical HPLC<\/li>\n<li><strong>Recommended Reconstitution Solvent:<\/strong> Sterile bacteriostatic water or sterile phosphate-buffered saline (PBS, pH 7.2\u20137.4). A mildly acidified sterile aqueous solution (such as 0.1% <i>acetic acid water<\/i>) can be used if required to enhance peptide stability.<\/li>\n<li><strong>Storage Conditions:<\/strong> Store long-term at -20 \u00b0C in a dry, dark environment. Following reconstitution, keep refrigerated at 2\u20138 \u00b0C in accordance with standard laboratory protocols.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Delgado, M., et al.<\/i> Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit the production of inflammatory mediators by activated microglia. <i>Journal of Leukocyte Biology<\/i>, 2003.<\/li>\n<li><i>Said, S. I., &amp; Mutt, V.<\/i> Polypeptide with broad biological activity: isolation from small intestine. <i>Science<\/i>, 1970.<\/li>\n<li><i>Gozes, I., &amp; Brenneman, D. E.<\/i> VIP: molecular biology and neuroprotective potential. <i>Molecular Neurobiology<\/i>, 1989.<\/li>\n<li><i>Pozo, D., et al.<\/i> Tuning immune tolerance with vasoactive intestinal peptide: A new therapeutic approach for autoimmune diseases. <i>Trends in Molecular Medicine<\/i>, 2007.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.<\/li>\n<li><strong>Form &amp; Contents:<\/strong> Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.<\/li>\n<li><strong>Recommended Storage:<\/strong> To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":1833,"template":"","meta":[],"product_brand":[],"product_cat":[47],"product_tag":[],"class_list":["post-1832","product","type-product","status-publish","has-post-thumbnail","product_cat-lyophilized-compounds","first","instock","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>VIP 5mg - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"VIP 5mg - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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