{"id":1840,"date":"2026-09-11T08:15:52","date_gmt":"2026-09-11T08:15:52","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/ahk-cu-100mg-2\/"},"modified":"2026-09-11T12:16:04","modified_gmt":"2026-09-11T12:16:04","slug":"ahk-cu-100mg-2","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/ahk-cu-100mg-2\/","title":{"rendered":"AHK-CU 100mg"},"content":{"rendered":"<p><strong>AHK-Cu<\/strong><\/p>\n<p><i>Synthetic tripeptide copper complex for in vitro research on extracellular matrix, fibroblasts, and endothelial signaling<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>AHK-Cu<\/strong> (Alanyl-Histidyl-Lysine Copper Complex) is a synthetic tripeptide chelated with divalent copper ions (Cu2+). In biochemical, dermatological, and cellular research, it serves as a specialized model complex for investigating the regulation of angiogenesis and extracellular matrix (ECM) remodeling:<\/p>\n<ul>\n<li><strong>Endothelial Cell Stimulation (VEGF Signaling):<\/strong> Monitoring cell proliferation, migration, and tube formation in endothelial cells (HUVEC) with a focus on vascular endothelial growth factor (VEGF) expression.<\/li>\n<li><strong>Extracellular Matrix Synthesis &amp; Remodeling:<\/strong> Evaluating type I and III collagen expression, elastin, and tissue inhibitors of metalloproteinases (TIMP) activity in cultured dermal fibroblasts.<\/li>\n<li><strong>Cellular Growth Modulation in Follicular Models:<\/strong> In vitro observation of dermal papilla cell (DPC) populations and evaluation of apoptosis-regulating factors (including Bcl-2 \/ Bax expression ratio and caspase inhibition).<\/li>\n<\/ul>\n<p>The AHK-Cu tripeptide chelate provides a stable transport system for copper ions, facilitating cellular uptake in laboratory media without inducing the cytotoxicity associated with free heavy metal ions.<\/p>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Research Peptide \/ Chelated Copper-Peptide Complex<\/li>\n<li><strong>Amino Acid Sequence:<\/strong> Ala-His-Lys (complexed with Cu2+)<\/li>\n<li><strong>Form:<\/strong> Sterile lyophilized blue powder (cake)<\/li>\n<li><strong>Molecular Weight Identification:<\/strong> Confirmed via Mass Spectrometry (MS)<\/li>\n<li><strong>Recommended Reconstitution Solvent:<\/strong> Sterile bacteriostatic water or sterile water for injection\/laboratory solutions (do not use phosphate buffers due to the risk of copper precipitation)<\/li>\n<li><strong>Storage Conditions:<\/strong> Long-term storage at -20 \u00b0C in a dry and dark environment. After reconstitution, store under refrigeration at 2\u20138 \u00b0C and consume in accordance with the experimental protocol.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Pyo, H. K., et al.<\/i> The effect of tripeptide-copper complex on human dermal papilla cells and vascular endothelial growth factor expression in vitro. <i>Archives of Pharmacal Research<\/i>, 2007.<\/li>\n<li><i>Pickart, L., et al.<\/i> Copper peptides in cell biology and tissue regeneration: Molecular pathways and gene modulation. <i>Biomolecules<\/i>, 2018.<\/li>\n<li><i>Gorouhi, F., &amp; Maibach, H. I.<\/i> Role of topical peptides in cellular matrix remodeling and vascular biology: In vitro and clinical mechanisms. <i>International Journal of Cosmetic Science<\/i>, 2009.<\/li>\n<li><i>Kim, M. S., et al.<\/i> Comparative analysis of synthetic copper complexes (GHK-Cu vs. AHK-Cu) on endothelial cell migration and matrix synthesis. <i>Journal of Dermatological Science<\/i>, 2012.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. The compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic use.<\/p>\n<p>By placing an order, the purchaser expressly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and technical equipment for handling research materials, and are fully familiar with safety protocols for managing research substances. The seller assumes no liability for use of the product contrary to these conditions.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.<\/li>\n<li><strong>Form &amp; Contents:<\/strong> Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.<\/li>\n<li><strong>Recommended Storage:<\/strong> To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":1841,"template":"","meta":[],"product_brand":[],"product_cat":[47],"product_tag":[],"class_list":["post-1840","product","type-product","status-publish","has-post-thumbnail","product_cat-lyophilized-compounds","first","instock","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>AHK-CU 100mg - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AHK-CU 100mg - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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