{"id":1848,"date":"2026-09-11T08:15:52","date_gmt":"2026-09-11T08:15:52","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/l-glutathione-1500mg\/"},"modified":"2026-09-11T12:16:04","modified_gmt":"2026-09-11T12:16:04","slug":"l-glutathione-1500mg","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/l-glutathione-1500mg\/","title":{"rendered":"L Glutathione 1500mg"},"content":{"rendered":"<p><strong>L-Glutathione (GSH)<\/strong><\/p>\n<p><i>Bioactive reduced intracellular tripeptide (<\/i>\u03b3<i>-L-glutamyl-L-cysteinylglycine) for in vitro research on cellular redox homeostasis, reactive oxygen species (ROS) quenching, phase II xenobiotic detoxification, and mitochondrial membrane integrity<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>L-Glutathione<\/strong> (specifically in its reduced form, <strong>GSH<\/strong>) is an endogenous intracellular tripeptide with the primary sequence <i>(<\/i>\u03b3<i>-L-Glu-L-Cys-Gly)<\/i>. It is defined by an atypical \u03b3-peptide linkage between the amino group of cysteine and the carboxyl group of the glutamate side chain, rendering it inherently resistant to intracellular peptidases. The active sulfhydryl group (-SH) on the cysteine residue serves as the principal cellular electron donor. In molecular toxicology, cellular bioenergetics, and immunological research, it serves as the universal reference standard for evaluating antioxidant mechanisms and detoxification cascades:<\/p>\n<ul>\n<li><strong>Maintenance of Cellular Redox Equilibrium (GSH\/GSSG Ratio):<\/strong> Direct regulation of the cytosolic and mitochondrial redox environment; acts as the primary buffer preventing oxidative damage to lipids, cellular structural proteins, and nucleic acids.<\/li>\n<li><strong>Cofactor for Enzymatic Antioxidant Systems:<\/strong> Functions as an obligate electron donor for glutathione peroxidase (GPx) in reducing lipid hydroperoxides and hydrogen peroxide into water, generating glutathione disulfide (GSSG), which is subsequently recycled back to GSH by glutathione reductase (GR) using NADPH.<\/li>\n<li><strong>Phase II Detoxification Reactions (GST Pathway):<\/strong> Facilitates covalent conjugation to electrophilic xenobiotics, heavy metals, and cytotoxic metabolic intermediates catalyzed by glutathione S-transferases (GST) in vitro.<\/li>\n<li><strong>Mitochondrial Protection &amp; Apoptosis Regulation:<\/strong> Shields inner mitochondrial cardiolipin against lipid peroxidation, stabilizes mitochondrial membrane potential (\u0394\u03a8m), and attenuates stress-induced caspase activation.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Research Tripeptide \/ Endogenous Reduced Antioxidant (\u03b3-Glu-Cys-Gly)<\/li>\n<li><strong>Chemical Name:<\/strong> \u03b3-L-Glutamyl-L-cysteinylglycine (Reduced Form \/ GSH)<\/li>\n<li><strong>Form:<\/strong> Sterile white crystalline \/ lyophilized powder<\/li>\n<li><strong>Component Identification:<\/strong> Verified via Mass Spectrometry (MS) and analytical HPLC<\/li>\n<li><strong>Recommended Reconstitution Solvent:<\/strong> Sterile deoxygenated water, sterile bacteriostatic water, or sterile phosphate-buffered saline (PBS, pH 7.2\u20137.4)<\/li>\n<li><strong>Storage Conditions:<\/strong> Store long-term at -20 \u00b0C in a dry, dark environment. Upon reconstitution in aqueous solution, GSH is prone to progressive atmospheric oxidation to GSSG; prepare fresh working solutions immediately prior to assays or store short-term at 2\u20138 \u00b0C under inert gas.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Meister, A., &amp; Anderson, M. E.<\/i> Glutathione. <i>Annual Review of Biochemistry<\/i>, 1983.<\/li>\n<li><i>Forman, H. J., et al.<\/i> Glutathione: Overview of its protective roles, measurement, and biosynthesis. <i>Molecular Aspects of Medicine<\/i>, 2009.<\/li>\n<li><i>Mar\u00ed, M., et al.<\/i> Mitochondrial glutathione, a key survival antioxidant. <i>Antioxidants &amp; Redox Signaling<\/i>, 2009.<\/li>\n<li><i>Franco, R., et al.<\/i> The central role of glutathione in the pathophysiology of human diseases and cell death pathways. <i>Archives of Physiology and Biochemistry<\/i>, 2007.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.<\/li>\n<li><strong>Form &amp; Contents:<\/strong> Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.<\/li>\n<li><strong>Recommended Storage:<\/strong> To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":1849,"template":"","meta":[],"product_brand":[],"product_cat":[47],"product_tag":[],"class_list":["post-1848","product","type-product","status-publish","has-post-thumbnail","product_cat-lyophilized-compounds","first","instock","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>L Glutathione 1500mg - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L Glutathione 1500mg - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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