{"id":1880,"date":"2026-09-11T08:15:52","date_gmt":"2026-09-11T08:15:52","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/ghrp-2-5mg\/"},"modified":"2026-09-11T12:16:05","modified_gmt":"2026-09-11T12:16:05","slug":"ghrp-2-5mg","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/ghrp-2-5mg\/","title":{"rendered":"GHRP &#8211; 2 5mg"},"content":{"rendered":"<p><strong>GHRP-2<\/strong><\/p>\n<p><i>Synthetic hexapeptide for in vitro research on growth hormone secretagogue receptor (GHS-R1a) signaling<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>GHRP-2<\/strong> (Growth Hormone Releasing Peptide-2, Pralmorelin) is a synthetic oligopeptide consisting of 6 amino acids (sequence <i>D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2<\/i>). In biochemical and endocrinological research, it serves as a model peptide secretagogue investigated for its selective affinity for the ghrelin receptor:<\/p>\n<ul>\n<li><strong>Activation of GHS-R1a Receptor:<\/strong> Binding to the G-protein coupled receptor (GHS-R1a) on isolated pituitary cell lines, leading to downstream activation of phospholipase C (PLC).<\/li>\n<li><strong>Intracellular Calcium Cascades:<\/strong> Monitoring of calcium ion (Ca2+) mobilization from the endoplasmic reticulum via the IP3 \/ DAG pathway in primary somatotrope cell cultures.<\/li>\n<li><strong>Interactions with Ghrelinergic Pathways:<\/strong> Analysis of receptor binding kinetics and competitive displacement assays against the endogenous ligand (acylated ghrelin) without altering non-targeted hormonal signaling axes.<\/li>\n<\/ul>\n<p>The incorporation of D-amino acids (D-Ala, D-2-Nal, D-Phe) alongside C-terminal amidation confers pronounced enzymatic stability against tissue endopeptidases and aminopeptidases in experimental settings.<\/p>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Research Peptide \/ GHS-R1a Receptor Agonist (Ghrelin Mimetic)<\/li>\n<li><strong>Amino Acid Sequence:<\/strong> D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2<\/li>\n<li><strong>Form:<\/strong> Sterile lyophilized white powder (cake)<\/li>\n<li><strong>Molecular Weight Identification:<\/strong> Confirmed via Mass Spectrometry (MS)<\/li>\n<li><strong>Recommended Reconstitution Solvent:<\/strong> Sterile bacteriostatic water or phosphate-buffered saline (PBS)<\/li>\n<li><strong>Storage Conditions:<\/strong> Store long-term at -20 \u00b0C in a dry, dark environment. Following reconstitution, keep refrigerated at 2\u20138 \u00b0C and utilize within standard experimental protocol timelines.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Bowers, C. Y., et al.<\/i> Structure-activity relationships of synthetic growth hormone-releasing peptides. <i>Endocrinology<\/i>, 1991.<\/li>\n<li><i>Howard, A. D., et al.<\/i> A receptor in pituitary and hypothalamus that functions in growth hormone release. <i>Science<\/i>, 1996.<\/li>\n<li><i>Smith, R. G., et al.<\/i> Peptidomimetic regulation of growth hormone secretagogue receptor signaling in cellular models. <i>Endocrine Reviews<\/i>, 2005.<\/li>\n<li><i>Kojima, M., et al.<\/i> Ghrelin and the GHS-R1a signaling network: Comparative analysis of synthetic secretagogues. <i>Journal of Molecular Endocrinology<\/i>, 2008.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.<\/li>\n<li><strong>Form &amp; Contents:<\/strong> Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.<\/li>\n<li><strong>Recommended Storage:<\/strong> To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":1881,"template":"","meta":[],"product_brand":[],"product_cat":[47],"product_tag":[],"class_list":["post-1880","product","type-product","status-publish","has-post-thumbnail","product_cat-lyophilized-compounds","first","instock","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>GHRP - 2 5mg - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"GHRP - 2 5mg - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.  Form &amp; Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.  Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).  Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nextrabiochem.eu\/en\/produkt\/ghrp-2-5mg\/\" \/>\n<meta property=\"og:site_name\" content=\"Nextrabiochem.eu\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-11T12:16:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/GHRP2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/ghrp-2-5mg\\\/\",\"url\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/ghrp-2-5mg\\\/\",\"name\":\"GHRP - 2 5mg - Nextrabiochem.eu\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/ghrp-2-5mg\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/ghrp-2-5mg\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/nextrabiochem.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/GHRP2.jpg\",\"datePublished\":\"2026-09-11T08:15:52+00:00\",\"dateModified\":\"2026-09-11T12:16:05+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/ghrp-2-5mg\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/ghrp-2-5mg\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/ghrp-2-5mg\\\/#primaryimage\",\"url\":\"https:\\\/\\\/nextrabiochem.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/GHRP2.jpg\",\"contentUrl\":\"https:\\\/\\\/nextrabiochem.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/GHRP2.jpg\",\"width\":1024,\"height\":1024},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/produkt\\\/ghrp-2-5mg\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Dom\u016f\",\"item\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Shop\",\"item\":\"https:\\\/\\\/nextrabiochem.eu\\\/en\\\/shop\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"GHRP &#8211; 2 5mg\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#website\",\"url\":\"https:\\\/\\\/nextrabiochem.eu\\\/\",\"name\":\"Nextrabiochem\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/nextrabiochem.eu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#organization\",\"name\":\"MALAM \u2013 PAGI \u2013 SORE LTD\",\"url\":\"https:\\\/\\\/nextrabiochem.eu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/nextrabiochem.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/logo-transparent.png\",\"contentUrl\":\"https:\\\/\\\/nextrabiochem.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/logo-transparent.png\",\"width\":1942,\"height\":809,\"caption\":\"MALAM \u2013 PAGI \u2013 SORE LTD\"},\"image\":{\"@id\":\"https:\\\/\\\/nextrabiochem.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"GHRP - 2 5mg - Nextrabiochem.eu","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"GHRP - 2 5mg - Nextrabiochem.eu","og_description":"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.  Form &amp; Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.  Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).  Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.","og_url":"https:\/\/nextrabiochem.eu\/en\/produkt\/ghrp-2-5mg\/","og_site_name":"Nextrabiochem.eu","article_modified_time":"2026-09-11T12:16:05+00:00","og_image":[{"width":1024,"height":1024,"url":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/GHRP2.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/ghrp-2-5mg\/","url":"https:\/\/nextrabiochem.eu\/en\/produkt\/ghrp-2-5mg\/","name":"GHRP - 2 5mg - Nextrabiochem.eu","isPartOf":{"@id":"https:\/\/nextrabiochem.eu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/ghrp-2-5mg\/#primaryimage"},"image":{"@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/ghrp-2-5mg\/#primaryimage"},"thumbnailUrl":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/GHRP2.jpg","datePublished":"2026-09-11T08:15:52+00:00","dateModified":"2026-09-11T12:16:05+00:00","breadcrumb":{"@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/ghrp-2-5mg\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/nextrabiochem.eu\/en\/produkt\/ghrp-2-5mg\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/ghrp-2-5mg\/#primaryimage","url":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/GHRP2.jpg","contentUrl":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/GHRP2.jpg","width":1024,"height":1024},{"@type":"BreadcrumbList","@id":"https:\/\/nextrabiochem.eu\/en\/produkt\/ghrp-2-5mg\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Dom\u016f","item":"https:\/\/nextrabiochem.eu\/en\/"},{"@type":"ListItem","position":2,"name":"Shop","item":"https:\/\/nextrabiochem.eu\/en\/shop\/"},{"@type":"ListItem","position":3,"name":"GHRP &#8211; 2 5mg"}]},{"@type":"WebSite","@id":"https:\/\/nextrabiochem.eu\/#website","url":"https:\/\/nextrabiochem.eu\/","name":"Nextrabiochem","description":"","publisher":{"@id":"https:\/\/nextrabiochem.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/nextrabiochem.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/nextrabiochem.eu\/#organization","name":"MALAM \u2013 PAGI \u2013 SORE LTD","url":"https:\/\/nextrabiochem.eu\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nextrabiochem.eu\/#\/schema\/logo\/image\/","url":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/logo-transparent.png","contentUrl":"https:\/\/nextrabiochem.eu\/wp-content\/uploads\/2026\/09\/logo-transparent.png","width":1942,"height":809,"caption":"MALAM \u2013 PAGI \u2013 SORE LTD"},"image":{"@id":"https:\/\/nextrabiochem.eu\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/product\/1880","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/media\/1881"}],"wp:attachment":[{"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/media?parent=1880"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/product_brand?post=1880"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/product_cat?post=1880"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/nextrabiochem.eu\/en\/wp-json\/wp\/v2\/product_tag?post=1880"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}