{"id":1912,"date":"2026-09-11T08:15:52","date_gmt":"2026-09-11T08:15:52","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/hexarelin-5mg\/"},"modified":"2026-09-11T12:16:05","modified_gmt":"2026-09-11T12:16:05","slug":"hexarelin-5mg","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/hexarelin-5mg\/","title":{"rendered":"Hexarelin 5mg"},"content":{"rendered":"<p><strong>Hexarelin<\/strong><\/p>\n<p><i>Synthetic bioactive hexapeptide growth hormone secretagogue (GHRP-6 structural analogue) for in vitro research on ghrelin receptor (GHS-R1a) activation, CD36 scavenger receptor signaling, intracellular calcium mobilization, and cardioprotective mechanisms<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>Hexarelin<\/strong> (also designated as <i>Examorelin<\/i> or <i>HEX<\/i>) is a synthetic six-amino-acid polypeptide belonging to the growth hormone secretagogue (<strong>GHRP<\/strong>) family. Structurally engineered from GHRP-6, it incorporates non-natural D-amino acids (D-Trp and 2-Me-D-Trp), conferring superior metabolic stability and high receptor binding affinity. It functions as a dual-action ligand stimulating both the classical growth hormone secretagogue receptor (<strong>GHS-R1a<\/strong>) and the <strong>CD36<\/strong> scavenger receptor. In molecular endocrinology, cardiovascular cell biology, and cellular physiology, it serves as a primary reference standard for studying somatotropic and cardioprotective pathways:<\/p>\n<ul>\n<li><strong>High-Affinity Activation of GHS-R1a Receptors:<\/strong> Direct binding to the G-protein coupled receptor GHS-R1a stimulates phospholipase C (PLC), generating inositol trisphosphate (IP3) and diacylglycerol (DAG) to trigger rapid intracellular calcium (Ca2+) mobilization in somatotroph cell models.<\/li>\n<li><strong>Cardioprotective Signaling via the CD36 Receptor:<\/strong> Independently of the somatotropic axis, Hexarelin binds to the cardiac scavenger receptor CD36 in myocardial and endothelial cultures, activating downstream cytoprotective kinase cascades, including Akt\/PI3K and ERK1\/2.<\/li>\n<li><strong>Suppression of Apoptosis &amp; Oxidative Stress:<\/strong> Inhibits caspase-3 cleavage, preserves mitochondrial membrane potential (\u0394\u03a8m), and reduces reactive oxygen species (ROS) accumulation in cardiomyocytes subjected to simulated hypoxia-reoxygenation injury in vitro.<\/li>\n<li><strong>Modulation of Autophagy &amp; Cellular Viability:<\/strong> Supports homeostatic autophagic flux and attenuates inflammatory cytokine secretion in vascular endothelial models.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Research Peptide \/ Growth Hormone Secretagogue (GHRP \/ GHS-R1a &amp; CD36 Agonist)<\/li>\n<li><strong>Amino Acid Sequence:<\/strong> H-His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2<\/li>\n<li><strong>Molecular Formula:<\/strong> C47H58N12O6<\/li>\n<li><strong>Molecular Weight:<\/strong> \u2248887.04\u00a0g\/mol<\/li>\n<li><strong>Form:<\/strong> Sterile lyophilized white powder (cake)<\/li>\n<li><strong>Component Identification:<\/strong> Verified via Mass Spectrometry (MS) and analytical HPLC<\/li>\n<li><strong>Recommended Reconstitution Solvent:<\/strong> Sterile bacteriostatic water or sterile phosphate-buffered saline (PBS, pH 7.2\u20137.4)<\/li>\n<li><strong>Storage Conditions:<\/strong> Store long-term at -20 \u00b0C in a dry, dark environment. Following reconstitution, keep refrigerated at 2\u20138 \u00b0C in accordance with standard laboratory protocols.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Ghigo, E., et al.<\/i> Biological activities of growth hormone secretagogues in humans and in vitro models. <i>Endocrine Reviews<\/i>, 1997.<\/li>\n<li><i>Muccioli, G., et al.<\/i> Synthetic hexapeptides (GHRP-6, Hexarelin) bind to distinct cardiac receptors and prevent myocardial ischemic damage. <i>Cardiovascular Research<\/i>, 2000.<\/li>\n<li><i>Bodart, V., et al.<\/i> Identification of a CD36-dependent cardioprotective pathway activated by growth hormone-releasing peptides. <i>Circulation Research<\/i>, 2002.<\/li>\n<li><i>Kojima, M., &amp; Kangawa, K.<\/i> Ghrelin and its synthetic analogs: Structure, receptors, and signaling mechanisms. <i>Physiological Reviews<\/i>, 2005.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.<\/li>\n<li><strong>Form &amp; Contents:<\/strong> Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.<\/li>\n<li><strong>Recommended Storage:<\/strong> To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":1913,"template":"","meta":[],"product_brand":[],"product_cat":[47],"product_tag":[],"class_list":["post-1912","product","type-product","status-publish","has-post-thumbnail","product_cat-lyophilized-compounds","first","instock","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hexarelin 5mg - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hexarelin 5mg - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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