{"id":1977,"date":"2026-09-11T08:15:52","date_gmt":"2026-09-11T08:15:52","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/cjc-1295-with-dac-5mg\/"},"modified":"2026-09-11T12:16:05","modified_gmt":"2026-09-11T12:16:05","slug":"cjc-1295-with-dac-5mg","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/cjc-1295-with-dac-5mg\/","title":{"rendered":"CJC-1295 with DAC 5mg"},"content":{"rendered":"<p><strong>CJC-1295 with DAC<\/strong><\/p>\n<p><i>Synthetic growth hormone-releasing hormone (GHRH) analog with Drug Affinity Complex technology for in vitro research on receptor signaling pathways<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>CJC-1295 with DAC<\/strong> (Drug Affinity Complex) is a synthetic 30-amino acid analog of natural GHRH(1\u201329). In biochemical and endocrinological research, it serves as a precision model for investigating selective GHRH receptor stimulation and extended interaction kinetics with cellular targets:<\/p>\n<ul>\n<li><strong>GHRH Receptor (GHRH-R) Activation:<\/strong> Binding to specific Gs-protein coupled receptors on isolated pituitary somatotrope membranes, driving intracellular cAMP synthesis and protein kinase A (PKA) cascade activation.<\/li>\n<li><strong>DAC (Drug Affinity Complex) Technology:<\/strong> Incorporation of a C-terminal maleimidopropionic acid (MPA) linker enables stable covalent bioconjugation to the thiol group (-SH) of albumin (specifically at Cys34) in biological media, preventing rapid proteolytic degradation.<\/li>\n<li><strong>DPP-4 Enzymatic Resistance:<\/strong> Strategic substitutions across four key positions (D-Ala2, Gln8, Ala15, Leu27) yield pronounced resistance against dipeptidyl peptidase-4 cleavage relative to native GHRH fragments.<\/li>\n<\/ul>\n<p>This structural optimization permits in vitro investigation of sustained baseline transcription and secretagogue cascades in cell cultures without requiring pulsatile re-administration.<\/p>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Research Peptide \/ Long-Acting GHRH Analog (GHRH-R Agonist)<\/li>\n<li><strong>Amino Acid Sequence:<\/strong> Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(MPA)-NH2<\/li>\n<li><strong>Form:<\/strong> Sterile lyophilized white powder (cake)<\/li>\n<li><strong>Molecular Weight Identification:<\/strong> Confirmed via Mass Spectrometry (MS)<\/li>\n<li><strong>Recommended Reconstitution Solvent:<\/strong> Sterile bacteriostatic water or sterile deionized laboratory water (avoid basic phosphate buffers to prevent premature hydrolysis of the maleimide DAC ring)<\/li>\n<li><strong>Storage Conditions:<\/strong> Store long-term at -20 \u00b0C in a dry, dark environment. Following reconstitution, keep refrigerated at 2\u20138 \u00b0C and utilize within standard experimental protocol timelines.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Teichman, S. L., et al.<\/i> Prolonged stimulation of growth hormone axis by CJC-1295, a long-acting GHRH analog: Pharmacokinetic and pharmacodynamic characterization. <i>The Journal of Clinical Endocrinology &amp; Metabolism<\/i>, 2006.<\/li>\n<li><i>Jette, L., et al.<\/i> hGRF1-29-albumin bioconjugates activate the GHRH receptor in vitro and exhibit prolonged stability in biological media. <i>Endocrinology<\/i>, 2005.<\/li>\n<li><i>Alba, M., et al.<\/i> Once-weekly administration of CJC-1295: Evaluation of receptor dynamics and intracellular signaling pathways in model systems. <i>European Journal of Endocrinology<\/i>, 2006.<\/li>\n<li><i>Sackmann-Sala, L., et al.<\/i> GHRH and its synthetic derivatives: Comparative receptor kinetics and structural stability assays. <i>Growth Hormone &amp; IGF Research<\/i>, 2009.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.<\/li>\n<li><strong>Form &amp; Contents:<\/strong> Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.<\/li>\n<li><strong>Recommended Storage:<\/strong> To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2\u20138 \u00b0C (recommended at -20 \u00b0C for long-term storage).<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":1978,"template":"","meta":[],"product_brand":[],"product_cat":[47],"product_tag":[],"class_list":["post-1977","product","type-product","status-publish","has-post-thumbnail","product_cat-lyophilized-compounds","first","instock","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CJC-1295 with DAC 5mg - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CJC-1295 with DAC 5mg - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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