{"id":223,"date":"2026-09-04T08:30:25","date_gmt":"2026-09-04T08:30:25","guid":{"rendered":"https:\/\/nextrabiochem.eu\/?post_type=product&#038;p=223"},"modified":"2026-09-04T08:51:28","modified_gmt":"2026-09-04T08:51:28","slug":"acetic-acid-water","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/acetic-acid-water\/","title":{"rendered":"Acetic acid water"},"content":{"rendered":"<p><strong>Acidic Reconstitution Medium for Laboratory Research (0.6% Acetic Acid Water \/ Dilute Acetic Acid)<\/strong><\/p>\n<p><em>Sterile, mildly acidified laboratory solvent containing 0.6% acetic acid for in vitro reconstitution of basic, hydrophobic, and aggregation-prone synthetic peptides (e.g., IGF-1, IGF-DES, mechano-growth factors) ensuring optimal protonation and solubility<\/em><\/p>\n<p><strong>Overview &amp; Functional Role in Laboratory Research (In Vitro)<\/strong><\/p>\n<p><strong>0.6% Acetic Acid Water<\/strong> (dilute sterile aqueous acetic acid solution) is a specialized acidic laboratory solvent engineered for the primary dissolution of peptides characterized by a high isoelectric point (), basic nature, or an elevated proportion of hydrophobic amino acids. Many synthetic peptide sequences and growth factors tend to spontaneously aggregate, form gels, or yield insoluble precipitates in neutral or basic buffer environments. A mildly acidic matrix effectively modifies the molecular surface charge, facilitating complete solvation:<\/p>\n<ul>\n<li><strong>Promotion of Protonation &amp; Aggregation Suppression:<\/strong> Acidic pH promotes the protonation of free amine groups and side chains of basic residues (lysine, arginine, histidine). The resulting net positive charge creates intermolecular electrostatic repulsion, preventing the formation of -sheet aggregates.<\/li>\n<li><strong>Solubilization of Poorly Soluble Sequences:<\/strong> Essential reconstitution reagent for lyophilized proteins and peptides exhibiting low solubility in standard sterile or bacteriostatic water (e.g., IGF-1 family sequences, E-peptides, and hydrophobic bioregulators).<\/li>\n<li><strong>Compatibility with Downstream Dilutions:<\/strong> Facilitates the preparation of an initial clear, concentrated stock solution that can subsequently be diluted with sterile water or physiological buffers (e.g., PBS) to targeted assay concentrations without precipitation.<\/li>\n<li><strong>High Analytical Purity &amp; Non-Pyrogenic Grade:<\/strong> Formulated using ultra-pure deionized water and HPLC-grade acetic acid, sterilized via 0.22 \u00a0membrane filtration with verified non-pyrogenic standards.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Specialized Laboratory Solvent \/ Acidic Reconstitution Reagent for Research (RUO)<\/li>\n<li><strong>Composition:<\/strong> Sterile deionized water (), 0.6% acetic acid (, analytical grade)<\/li>\n<li><strong>pH Range:<\/strong> 2.5 \u2013 3.5<\/li>\n<li><strong>Form:<\/strong> Clear, colorless sterile liquid solution with a faint characteristic acetic odor<\/li>\n<li><strong>Quality Standard:<\/strong> 0.22 \u00a0membrane filtered, endotoxin-free \/ non-pyrogenic quality<\/li>\n<li><strong>Recommended Application Protocol:<\/strong> Typically utilized for the initial dissolution of the lyophilizate (representing 10\u201320% of the final intended volume for complete peptide solvation), followed by dilution with sterile water or bacteriostatic water according to the specific experimental design.<\/li>\n<li><strong>Storage Conditions:<\/strong> Store unopened at 15\u201325 \u00b0C (room temperature) in a dry, dark environment in a tightly sealed container. Following initial access, store refrigerated at 2\u20138 \u00b0C in compliance with standard Good Laboratory Practice (GLP) protocols. Protect from freezing.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><em>Manning, M. C., et al.<\/em> Physical and chemical degradation pathways of peptide reagents: Optimization of solubilization and pH control. <em>Pharmaceutical Research<\/em>, 2010.<\/li>\n<li><em>Hopp, T. P., &amp; Woods, K. R.<\/em> Prediction of protein antigenic determinants and hydrophobic residue solubility in aqueous organic acids. <em>Proceedings of the National Academy of Sciences<\/em>, 1981.<\/li>\n<li><em>Nilsson, M., et al.<\/em> Solubilization and reconstitution strategies for recombinant human IGF-1 and hydrophobic peptide fragments. <em>Biochemical Journal<\/em>, 1991.<\/li>\n<li><em>European Pharmacopoeia (Ph. Eur.).<\/em> Reagents and Standards: Dilute Acetic Acid Solutions for Analytical and Laboratory Chromatography.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is intended <strong>strictly for laboratory, analytical, and research purposes only (Research Use Only \/ in vitro)<\/strong> for reconstitution, dilution, and preparation of laboratory solutions. It is not a medicinal product, infusion solution, or sterile injectable intended for administration to humans or animals.<\/li>\n<li><strong>Form &amp; Specification:<\/strong> Sterile laboratory solvent supplied in a sealed glass or polymer container designed for precise laboratory handling.<\/li>\n<li><strong>Recommended Storage:<\/strong> Store in the original sealed container at 15\u201325 \u00b0C in a dry, dark place. After opening, refrigeration (2\u20138 \u00b0C) is recommended, and contents should be handled according to standard laboratory protocols.<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. Container geometry, closure coloration, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":222,"template":"","meta":[],"product_brand":[],"product_cat":[49],"product_tag":[],"class_list":["post-223","product","type-product","status-publish","has-post-thumbnail","product_cat-solvents-reconstitution","pa_obsah-10ml","pa_obsah-3ml","first","instock","shipping-taxable","purchasable","product-type-variable","has-default-attributes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Acetic acid water - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Acetic acid water - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is intended strictly for laboratory, analytical, and research purposes only (Research Use Only \/ in vitro) for reconstitution, dilution, and preparation of laboratory solutions. 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