{"id":2453,"date":"2026-09-17T20:12:12","date_gmt":"2026-09-17T20:12:12","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/glp-3-r3t-capsules\/"},"modified":"2026-09-17T21:05:36","modified_gmt":"2026-09-17T21:05:36","slug":"glp-3-r3t-capsules","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/glp-3-r3t-capsules\/","title":{"rendered":"GLP-3 R3T Capsules"},"content":{"rendered":"<p><strong>GLP-3 R3T \u2013 Research Capsules for Laboratory Purposes (2 mg \/ capsule, 60 count)<\/strong><\/p>\n<p><i>Synthetic bioactive acylated peptide tri-agonist of GLP-1R, GIPR, and GCGR receptors in a solid analytical matrix for in vitro research on multi-receptor signaling, cellular bioenergetics, intracellular cAMP modulation, and lipid flux in primary cell lines<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>GLP-3 R3T<\/strong> (a laboratory research code designated for an advanced acylated tri-agonist peptide with a conjugated fatty diacid lipid anchor) is a highly stable polypeptide designed as a balanced, multi-target ligand capable of simultaneously activating three key metabolic receptors: the glucagon-like peptide-1 receptor (<strong>GLP-1R<\/strong>), the glucose-dependent insulinotropic polypeptide receptor (<strong>GIPR<\/strong>), and the glucagon receptor (<strong>GCGR<\/strong>). Encapsulation into a standardized solid matrix ensures precise aliquot dispensing and protects the compound from ambient humidity and premature degradation prior to laboratory assay preparation:<\/p>\n<ul>\n<li><strong>Synergistic Tri-Agonist Profile (GLP-1R \/ GIPR \/ GCGR):<\/strong> Coordinated stimulation of all three G-protein coupled receptors (G\u03b1s) induces additive adenylyl cyclase activation and a robust increase in intracellular cyclic AMP (cAMP) levels, surpassing the capacity of mono- or dual agonists.<\/li>\n<li><strong>Potentiation of Mitochondrial Respiration &amp; Fatty Acid Oxidation:<\/strong> Concurrent activation of GCGR and GIPR branches induces AMPK phosphorylation and upregulates enzymes responsible for \u03b2-oxidation in primary hepatocyte and adipocyte cell models in vitro.<\/li>\n<li><strong>Cellular Stress Mitigation &amp; Cytoprotection:<\/strong> Activation of GLP-1R and GIPR signaling axes reduces biomarkers of endoplasmic reticulum (ER) stress and protects target cell lines against lipotoxicity-induced and oxidative stress-induced apoptosis.<\/li>\n<li><strong>Precise Quantification for In Vitro Assays:<\/strong> The solid capsule matrix serves as a stable vehicle containing an exact mass of the lyophilized analytical standard (2 mg) for simplified serial dilution workflows in culture media or assay buffers.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Research Peptide Tri-Agonist in Solid Matrix \/ Reagent Analytical Capsules (RUO)<\/li>\n<li><strong>Active Content:<\/strong> 2 mg per capsule (\u00b12%)<\/li>\n<li><strong>Packaging Unit:<\/strong> 60 research capsules in a laboratory container with integrated desiccant<\/li>\n<li><strong>Form:<\/strong> Solid reagent matrix \/ encapsulated powder standard<\/li>\n<li><strong>Component Identification:<\/strong> Verified via Analytical HPLC and Mass Spectrometry (MS)<\/li>\n<li><strong>Recommended Reconstitution Protocol:<\/strong> Capsule contents are intended for dissolution in suitable laboratory media (e.g., sterile PBS with mildly basic pH 7.4\u20138.0, DMSO for stock solutions, or sterile water) to achieve defined test concentrations for cellular assays.<\/li>\n<li><strong>Storage Conditions:<\/strong> Store at 15\u201325 \u00b0C in a dry, dark environment in the tightly sealed original container with desiccant. For long-term standard archiving, storage at -20 \u00b0C is recommended.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Finan, B., et al.<\/i> A balanced unimolecular tri-agonist targeting GLP-1, GIP, and glucagon receptors enhances cellular energy expenditure and metabolic control. <i>Nature Medicine<\/i>, 2015.<\/li>\n<li><i>Coskun, T., et al.<\/i> LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist: In vitro pharmacology and robust multi-receptor signaling cascades. <i>Cell Metabolism<\/i>, 2022.<\/li>\n<li><i>Gault, V. A., et al.<\/i> Multi-incretin receptor agonists in cellular metabolic homeostasis: Mechanisms of receptor cross-talk and cAMP dynamics. <i>Frontiers in Endocrinology<\/i>, 2020.<\/li>\n<li><i>Knerr, P. J., et al.<\/i> Next-generation peptide multi-agonists: Structural optimization, fatty acid conjugation, and in vitro stability profiling. <i>Journal of Medicinal Chemistry<\/i>, 2021.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The compound in a solid carrier is not intended for application, consumption, or any therapeutic use in humans or animals.<\/li>\n<li><strong>Form &amp; Presentation:<\/strong> Contains precisely pre-weighed research material within an enclosed capsule carrier for convenient laboratory handling.<\/li>\n<li><strong>Recommended Storage:<\/strong> Store in the original sealed container in a cool, dry, and dark place at temperatures up to 20 \u00b0C. Protect from moisture and direct sunlight.<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. Capsule coloration, packaging format, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":2454,"template":"","meta":[],"product_brand":[],"product_cat":[46],"product_tag":[],"class_list":["post-2453","product","type-product","status-publish","has-post-thumbnail","product_cat-research-capsules","first","instock","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>GLP-3 R3T Capsules - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"GLP-3 R3T Capsules - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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