{"id":2485,"date":"2026-09-17T20:12:12","date_gmt":"2026-09-17T20:12:12","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/mk-677-capsules\/"},"modified":"2026-09-17T21:05:39","modified_gmt":"2026-09-17T21:05:39","slug":"mk-677-capsules","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/mk-677-capsules\/","title":{"rendered":"MK-677 Capsules"},"content":{"rendered":"<p><strong>MK-677 \u2013 Research Capsules for Laboratory Purposes (10 mg \/ capsule, 60 count)<\/strong><\/p>\n<p><i>Synthetic non-peptide selective ghrelin receptor agonist (GHSR-1a) and growth hormone secretagogue in a solid analytical matrix for in vitro research on GH\/IGF-1 axis signaling, cellular bioenergetics, protein synthesis, and neuroprotective pathways<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>MK-677<\/strong> (Ibutamoren methanesulfonate) is a highly selective, synthetic non-peptide small molecule developed as a potent agonist of the growth hormone secretagogue receptor type 1a (<strong>GHSR-1a<\/strong>, ghrelin receptor). In cellular endocrinology, molecular biology, and biochemical research, it serves as a primary reference standard for mapping ghrelin receptor signaling cascades, intracellular calcium mobilization, and the somatotropic axis in primary and immortalized cell models:<\/p>\n<ul>\n<li><strong>Selective Activation of GHSR-1a Receptor:<\/strong> Binding to GHSR-1a coupled with G\u03b1q\/11 proteins activates phospholipase C (PLC), resulting in inositol trisphosphate (IP3) and diacylglycerol (DAG) generation, followed by calcium (Ca2+) mobilization from the endoplasmic reticulum.<\/li>\n<li><strong>Modulation of the GH\/IGF-1 Axis In Vitro:<\/strong> Stimulates growth hormone transcription in pituitary cell cultures and upregulates insulin-like growth factor 1 (<strong>IGF-1<\/strong>) expression in primary hepatocyte models.<\/li>\n<li><strong>Promotion of Anabolism &amp; Protein Synthesis in Myoblasts:<\/strong> Enhances PI3K\/Akt\/mTOR signaling pathway activity, driving protein synthesis and downregulating muscle atrophy markers (such as MuRF1 and Atrogin-1 ligases) in myotube cultures.<\/li>\n<li><strong>Neuroprotection &amp; Mitochondrial Homeostasis:<\/strong> GHSR-1a activation in neuronal cell lines suppresses apoptosis induced by oxidative stress and enhances cellular survival through mitochondrial functional support.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Selective GHSR-1a Agonist \/ Small Molecule in Solid Matrix \/ Reagent Analytical Capsules (RUO)<\/li>\n<li><strong>Chemical Name:<\/strong> 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4&#8242;-piperidin]-1&#8242;-yl)-1-oxo-3-(phenylmethoxy)propan-2-yl]propanamide; methanesulfonic acid<\/li>\n<li><strong>Molecular Formula:<\/strong> C27H36N4O5S\u22c5CH4O3S<\/li>\n<li><strong>Active Content:<\/strong> 10 mg per capsule (\u00b12%)<\/li>\n<li><strong>Packaging Unit:<\/strong> 60 research capsules in a laboratory container with integrated desiccant<\/li>\n<li><strong>Form:<\/strong> Solid reagent matrix \/ encapsulated standard<\/li>\n<li><strong>Component Identification:<\/strong> Verified via Analytical HPLC and Mass Spectrometry (MS \/ NMR)<\/li>\n<li><strong>Recommended Reconstitution Protocol:<\/strong> Capsule contents are intended for dissolution in suitable laboratory solvents (e.g., DMSO or sterile assay buffers) to prepare calibrated stock solutions for in vitro assays.<\/li>\n<li><strong>Storage Conditions:<\/strong> Store at 15\u201325 \u00b0C in a dry, dark environment in the tightly sealed original container with desiccant. For long-term archiving of analytical standards, storage at -20 \u00b0C is recommended.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Patchett, A. A., et al.<\/i> Design and biological activities of L-163,191 (MK-0677): A potent, orally active growth hormone secretagogue. <i>Proceedings of the National Academy of Sciences<\/i>, 1995.<\/li>\n<li><i>Smith, R. G., et al.<\/i> Growth hormone secretagogue receptor: In vitro signal transduction mechanisms and endocrine regulation. <i>Endocrine Reviews<\/i>, 1997.<\/li>\n<li><i>Murphy, M. G., et al.<\/i> MK-677 increases plasma growth hormone and insulin-like growth factor I levels: In vitro receptor characterization and cellular dynamics. <i>The Journal of Clinical Endocrinology &amp; Metabolism<\/i>, 1998.<\/li>\n<li><i>Chung, H., et al.<\/i> Ghrelin receptor agonist MK-677 protects against neuronal cell death via the PI3K\/Akt signaling pathway in vitro. <i>Neurochemistry International<\/i>, 2013.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The compound in a solid carrier is not intended for application, consumption, or any therapeutic use in humans or animals.<\/li>\n<li><strong>Form &amp; Presentation:<\/strong> Contains precisely pre-weighed research material within an enclosed capsule carrier for convenient laboratory handling.<\/li>\n<li><strong>Recommended Storage:<\/strong> Store in the original sealed container in a cool, dry, and dark place at temperatures up to 20 \u00b0C. Protect from moisture and direct sunlight.<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. Capsule coloration, packaging format, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":2486,"template":"","meta":[],"product_brand":[],"product_cat":[46],"product_tag":[],"class_list":["post-2485","product","type-product","status-publish","has-post-thumbnail","product_cat-research-capsules","first","instock","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>MK-677 Capsules - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MK-677 Capsules - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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