{"id":2493,"date":"2026-09-17T20:12:12","date_gmt":"2026-09-17T20:12:12","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/nad-capsules\/"},"modified":"2026-09-17T21:05:40","modified_gmt":"2026-09-17T21:05:40","slug":"nad-capsules","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/nad-capsules\/","title":{"rendered":"NAD+ Capsules"},"content":{"rendered":"<p><strong>NAD+ \u2013 Research Capsules for Laboratory Purposes (500 mg \/ capsule, 60 count)<\/strong><\/p>\n<p><i>Highly purified bioactive coenzyme nicotinamide adenine dinucleotide (<\/i>\u03b2-NAD+<i>) in a solid analytical matrix for in vitro research on cellular bioenergetics, sirtuin activity (SIRT1\u2013SIRT7), PARP enzyme function, mitochondrial oxidative metabolism, and DNA repair mechanisms<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>NAD+<\/strong> (\u03b2-nicotinamide adenine dinucleotide) is an essential intracellular coenzyme and central redox cofactor present across all living cells. In molecular biology, cellular bioenergetics, and aging research, it serves as a critical substrate for NAD+-consuming enzymes that regulate epigenetic modifications, genomic stability, and mitochondrial respiration. Encapsulation into a standardized solid matrix ensures high cofactor stability, prevents spontaneous oxidation and moisture absorption, and allows accurate aliquot weighing for laboratory testing:<\/p>\n<ul>\n<li><strong>Obligate Co-Substrate for Sirtuin Enzymes (SIRT1\u2013SIRT7):<\/strong> Serves as an essential cofactor for NAD+-dependent protein deacetylases (SIRT1, SIRT3), regulating downstream transcription factors (e.g., PGC-1$alpha$, FOXO) that drive mitochondrial biogenesis, oxidative phosphorylation, and cellular antioxidant responses in vitro.<\/li>\n<li><strong>Activation of PARP Enzymes in DNA Damage Repair:<\/strong> Acts as an ADP-ribose donor for poly(ADP-ribose) polymerases (particularly PARP-1), which are required for single-strand break detection and the orchestration of enzymatic repair cascades under genotoxic stress.<\/li>\n<li><strong>Electron Transfer in the Mitochondrial Respiratory Chain:<\/strong> Maintains the central NAD+\/NADH redox couple essential for driving glycolysis, the tricarboxylic acid (TCA) cycle, and complex I electron transport during ATP generation.<\/li>\n<li><strong>Modulation of CD38\/CD157 &amp; Calcium Signaling:<\/strong> Participates in the enzymatic synthesis of cyclic ADP-ribose (cADPR), a key secondary messenger modulating intracellular calcium (Ca2+) mobilization.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Intracellular Coenzyme \/ Bioenergetics Analytical Standard in Solid Matrix (RUO)<\/li>\n<li><strong>Chemical Name:<\/strong> \u03b2-Nicotinamide adenine dinucleotide (oxidized form)<\/li>\n<li><strong>Molecular Formula:<\/strong> C21H27N7O14P2<\/li>\n<li><strong>Molecular Weight:<\/strong> 663.43\u00a0g\/mol<\/li>\n<li><strong>Active Content:<\/strong> 500 mg per capsule (\u00b12%)<\/li>\n<li><strong>Packaging Unit:<\/strong> 60 research capsules in a laboratory container with integrated desiccant<\/li>\n<li><strong>Form:<\/strong> Solid reagent matrix \/ encapsulated standard<\/li>\n<li><strong>Component Identification:<\/strong> Verified via Analytical HPLC and Spectrophotometric Assay (absorbance at 260 nm)<\/li>\n<li><strong>Recommended Reconstitution Protocol:<\/strong> Capsule contents are intended for dissolution in sterile laboratory buffers (e.g., sterile PBS pH 7.2\u20137.4) or sterile deionized water to prepare calibrated working solutions for in vitro cellular assays. Reconstituted aqueous solutions should be used immediately or stored frozen to prevent spontaneous hydrolysis.<\/li>\n<li><strong>Storage Conditions:<\/strong> Store at 15\u201325 \u00b0C in a dry, dark environment in the tightly sealed original container with desiccant. For long-term archiving of analytical standards, storage at -20 \u00b0C is recommended.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Imai, S., &amp; Guarente, L.<\/i> NAD+ and sirtuins in aging and disease. <i>Trends in Cell Biology<\/i>, 2014.<\/li>\n<li><i>Cant\u00f3, C., et al.<\/i> NAD+ metabolism and the control of energy homeostasis: A balancing act between mitochondria and the nucleus. <i>Cell Metabolism<\/i>, 2015.<\/li>\n<li><i>Verdin, E.<\/i> NAD\u207a in aging, metabolism, and neurodegeneration. <i>Science<\/i>, 2015.<\/li>\n<li><i>Bai, P., et al.<\/i> Poly(ADP-ribose) polymerases as modulators of cellular energy metabolism and DNA damage response. <i>Molecular Cell<\/i>, 2011.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The compound in a solid carrier is not intended for application, consumption, or any therapeutic use in humans or animals.<\/li>\n<li><strong>Form &amp; Presentation:<\/strong> Contains precisely pre-weighed research material within an enclosed capsule carrier for convenient laboratory handling.<\/li>\n<li><strong>Recommended Storage:<\/strong> Store in the original sealed container in a cool, dry, and dark place at temperatures up to 20 \u00b0C. Protect from moisture and direct sunlight.<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. Capsule coloration, packaging format, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":2708,"template":"","meta":[],"product_brand":[],"product_cat":[46],"product_tag":[],"class_list":["post-2493","product","type-product","status-publish","has-post-thumbnail","product_cat-research-capsules","first","instock","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NAD+ Capsules - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NAD+ Capsules - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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