{"id":2547,"date":"2026-09-17T20:12:12","date_gmt":"2026-09-17T20:12:12","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/bam-15-capsules\/"},"modified":"2026-09-17T21:05:43","modified_gmt":"2026-09-17T21:05:43","slug":"bam-15-capsules","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/bam-15-capsules\/","title":{"rendered":"BAM-15 Capsules"},"content":{"rendered":"<p><strong>BAM-15 \u2013 Research Capsules for Laboratory Purposes (100 mg \/ capsule, 30 count)<\/strong><\/p>\n<p><i>Synthetic selective mitochondrial protonophore and uncoupler of oxidative phosphorylation (N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine) in a solid analytical matrix for in vitro research on mitochondrial respiration, bioenergetic flux, lipid oxidation, and oxidative stress reduction without plasma membrane depolarization<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>BAM-15<\/strong> is a synthetic small molecule developed as a next-generation, highly selective mitochondrial uncoupler. In cellular bioenergetics, mitochondrial physiology, and metabolic research, it serves as a primary reference tool for investigating cellular respiration and substrate oxidation dynamics. Unlike classical uncoupling agents (such as DNP or FCCP), it selectively depolarizes the inner mitochondrial membrane without altering the cell&#8217;s plasma membrane potential:<\/p>\n<ul>\n<li><strong>Selective Mitochondrial Protonophore Transport:<\/strong> Facilitates the controlled trans-membrane translocation of protons (H+) across the inner mitochondrial membrane back into the matrix independently of ATP synthase, effectively uncoupling the electron transport chain from ATP phosphorylation.<\/li>\n<li><strong>Stimulation of Mitochondrial Oxygen Consumption (OCR) &amp; Substrate Flux:<\/strong> Increases maximal respiratory capacity and basal oxygen consumption rates in primary myocytes, hepatocytes, and adipocytes in vitro, accelerating fatty acid \u03b2-oxidation and glucose flux.<\/li>\n<li><strong>Absence of Non-Specific Cytotoxicity &amp; Maintenance of Cellular Integrity:<\/strong> Does not cause plasma membrane depolarization, preserving intracellular ion homeostasis and showing no cytotoxic off-target effects across a broad analytical testing range.<\/li>\n<li><strong>Attenuation of Mitochondrial Reactive Oxygen Species (ROS):<\/strong> Mild reduction of mitochondrial membrane potential (\u0394\u03a8m) effectively suppresses superoxide generation at respiratory complexes I and III, protecting cultured cells from oxidative stress and macromolecular damage in vitro.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Selective Mitochondrial Uncoupler \/ Small Molecule Standard in Solid Matrix (RUO)<\/li>\n<li><strong>Chemical Name:<\/strong> N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine<\/li>\n<li><strong>Molecular Formula:<\/strong> C16H10F2N6O<\/li>\n<li><strong>Molecular Weight:<\/strong> 340.29\u00a0g\/mol<\/li>\n<li><strong>Active Content:<\/strong> 100 mg per capsule (\u00b12%)<\/li>\n<li><strong>Packaging Unit:<\/strong> 30 research capsules in a laboratory container with integrated desiccant<\/li>\n<li><strong>Form:<\/strong> Solid reagent matrix \/ encapsulated standard<\/li>\n<li><strong>Component Identification:<\/strong> Verified via Analytical HPLC and Mass Spectrometry (MS \/ NMR)<\/li>\n<li><strong>Recommended Reconstitution Protocol:<\/strong> Capsule contents are intended for dissolution in suitable laboratory solvents (e.g., DMSO for concentrated stock solutions or sterile laboratory assay buffers) to prepare calibrated working solutions for in vitro bioassays.<\/li>\n<li><strong>Storage Conditions:<\/strong> Store at 15\u201325 \u00b0C in a dry, dark environment in the tightly sealed original container with desiccant. For long-term archiving of analytical standards, storage at -20 \u00b0C is recommended.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Kenwood, B. M., et al.<\/i> Identification of a novel mitochondrial uncoupler (BAM15) that protects against acute renal ischemic-reperfusion injury and selectively depolarizes mitochondrial membrane in vitro. <i>Molecular Metabolism<\/i>, 2014.<\/li>\n<li><i>Alexopoulos, S. J., et al.<\/i> Mitochondrial uncoupler BAM15 reverses diet-induced obesity and improves cellular bioenergetics without depolarizing the plasma membrane. <i>Nature Communications<\/i>, 2020.<\/li>\n<li><i>Dykstra, C. B., et al.<\/i> Characterization of BAM15-mediated cellular oxygen consumption and metabolic flux in primary cell lines. <i>Biochemical Journal<\/i>, 2021.<\/li>\n<li><i>Axelrod, C. L., et al.<\/i> BAM15-mediated mitochondrial uncoupling attenuates cellular senescence and improves metabolic markers in vitro. <i>Aging Cell<\/i>, 2022.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The compound in a solid carrier is not intended for application, consumption, or any therapeutic use in humans or animals.<\/li>\n<li><strong>Form &amp; Presentation:<\/strong> Contains precisely pre-weighed research material within an enclosed capsule carrier for convenient laboratory handling.<\/li>\n<li><strong>Recommended Storage:<\/strong> Store in the original sealed container in a cool, dry, and dark place at temperatures up to 20 \u00b0C. Protect from moisture and direct sunlight.<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. Capsule coloration, packaging format, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":2548,"template":"","meta":[],"product_brand":[],"product_cat":[46],"product_tag":[],"class_list":["post-2547","product","type-product","status-publish","has-post-thumbnail","product_cat-research-capsules","first","instock","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>BAM-15 Capsules - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BAM-15 Capsules - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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