{"id":2567,"date":"2026-09-17T20:12:12","date_gmt":"2026-09-17T20:12:12","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/bpc-157-capsules\/"},"modified":"2026-09-17T21:05:46","modified_gmt":"2026-09-17T21:05:46","slug":"bpc-157-capsules","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/bpc-157-capsules\/","title":{"rendered":"BPC-157 Capsules"},"content":{"rendered":"<p><strong>BPC-157 \u2013 Research Capsules for Laboratory Purposes (500 mcg \/ capsule, 60 count)<\/strong><\/p>\n<p><i>Synthetic bioactive pentadecapeptide derived from body protection compound in a solid analytical matrix for in vitro research on angiogenesis, FAK-paxillin pathway activation, collagen synthesis, tight junction integrity, and cytoprotection<\/i><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>BPC-157<\/strong> (Body Protection Compound-157) is a stable synthetic 15-amino acid pentadecapeptide derived from the functional sequence of a native gastric protein. In cellular biology, experimental gastroenterology, and tissue engineering, it serves as a fundamental reference standard for investigating tissue structure repair, nitric oxide (NO) pathway modulation, and cellular integrity. Formulation in a standardized solid matrix ensures chemical stability, precise aliquot dispensing, and protection from ambient humidity:<\/p>\n<ul>\n<li><strong>Stimulation of Fibroblast Migration &amp; Type I Collagen Synthesis:<\/strong> Activates the intracellular FAK-paxillin (Focal Adhesion Kinase) signaling cascade, promoting adhesion, cytoskeletal remodeling, and collagenous matrix production in primary fibroblast lines in vitro.<\/li>\n<li><strong>Angiogenesis &amp; Endothelial Organization:<\/strong> Upregulates vascular endothelial growth factor receptor 2 (VEGFR2) expression and promotes capillary tube formation in endothelial cell models.<\/li>\n<li><strong>Enhancement of Tight Junction Integrity:<\/strong> Modulates the expression of zonula occludens-1 (ZO-1) and occludin in epithelial cell monolayers subjected to chemical stress, reducing paracellular permeability in vitro.<\/li>\n<li><strong>eNOS Modulation &amp; Antioxidant Defense:<\/strong> Balances endothelial nitric oxide synthase (eNOS) activity and attenuates the accumulation of reactive oxygen species (ROS) in cell cultures under oxidative stress.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Research Peptide in Solid Matrix \/ Reagent Analytical Capsules (RUO)<\/li>\n<li><strong>Amino Acid Sequence:<\/strong> Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val<\/li>\n<li><strong>Active Content:<\/strong> 500 mcg (0.5 mg) per capsule (\u00b12%)<\/li>\n<li><strong>Packaging Unit:<\/strong> 60 research capsules in a laboratory container with integrated desiccant<\/li>\n<li><strong>Form:<\/strong> Solid reagent matrix \/ encapsulated powder standard<\/li>\n<li><strong>Component Identification:<\/strong> Verified via Analytical HPLC and Mass Spectrometry (MS)<\/li>\n<li><strong>Recommended Reconstitution Protocol:<\/strong> Capsule contents are intended for dissolution in sterile laboratory buffers (e.g., sterile PBS pH 7.2\u20137.4) or sterile water to prepare calibrated working solutions for in vitro cellular assays.<\/li>\n<li><strong>Storage Conditions:<\/strong> Store at 15\u201325 \u00b0C in a dry, dark environment in the tightly sealed original container with desiccant. For long-term archiving of analytical standards, storage at -20 \u00b0C is recommended.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><i>Sikiric, P., et al.<\/i> Focus on ulcerative colitis: stable gastric pentadecapeptide BPC 157 and cellular pathways of tissue repair. <i>Current Medicinal Chemistry<\/i>, 2012.<\/li>\n<li><i>Chang, C. H., et al.<\/i> The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. <i>Journal of Applied Physiology<\/i>, 2011.<\/li>\n<li><i>Hsieh, T. C., et al.<\/i> The effect of BPC-157 on the expression of growth factor receptors and migration of vascular endothelial cells in vitro. <i>Molecular and Cellular Biochemistry<\/i>, 2017.<\/li>\n<li><i>Vukojevic, J., et al.<\/i> Pentadecapeptide BPC 157 and the central nervous system: In vitro neuroprotection and cellular integrity. <i>Neural Regeneration Research<\/i>, 2018.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product, food, or dietary supplement. The compound in a solid carrier is not intended for application, consumption, or any therapeutic use in humans or animals.<\/li>\n<li><strong>Form &amp; Presentation:<\/strong> Contains precisely pre-weighed research material within an enclosed capsule carrier for convenient laboratory handling.<\/li>\n<li><strong>Recommended Storage:<\/strong> Store in the original sealed container in a cool, dry, and dark place at temperatures up to 20 \u00b0C. Protect from moisture and direct sunlight.<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. Capsule coloration, packaging format, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":2568,"template":"","meta":[],"product_brand":[],"product_cat":[46],"product_tag":[],"class_list":["post-2567","product","type-product","status-publish","has-post-thumbnail","product_cat-research-capsules","first","instock","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>BPC-157 Capsules - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BPC-157 Capsules - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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