{"id":84,"date":"2026-09-03T07:21:27","date_gmt":"2026-09-03T07:21:27","guid":{"rendered":"https:\/\/nextrabiochem.eu\/?post_type=product&#038;p=84"},"modified":"2026-09-03T08:59:43","modified_gmt":"2026-09-03T08:59:43","slug":"cagrilintide-10mg","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/cagrilintide-10mg\/","title":{"rendered":"Cagrilintide 10mg"},"content":{"rendered":"<p><strong>Cagrilintide \u2013 Pre-filled Laboratory Cartridge for In Vitro Research (10 mg \/ 3 ml)<\/strong><\/p>\n<p><em>Synthetic long-acting acylated amylin receptor agonist and AMY1\u20133\/CTR non-selective modulator in a pre-formulated stabilized buffered solution for in vitro research on neuroendocrine signaling, receptor heterodimerization, and metabolic flux modulation<\/em><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>Cagrilintide<\/strong> is an advanced synthetic acylated peptide analogue engineered from the endogenous neuroendocrine peptide amylin. In molecular endocrinology, cellular neurobiology, and metabolic receptor research, it serves as a primary reference standard for investigating amylin receptor complexes and downstream intracellular cascades across cell culture models:<\/p>\n<ul>\n<li><strong>Non-Selective Pan-Agonism across Amylin Receptors (AMY1\u20133) and CTR:<\/strong> Displays high binding affinity for heterodimeric amylin receptor complexes formed by the association of the calcitonin receptor (CTR) core with receptor activity-modifying proteins (RAMP1, RAMP2, and RAMP3), facilitating granular in vitro receptor profiling.<\/li>\n<li><strong>Activation of cAMP and Downstream Kinase Cascades:<\/strong> Triggers intracellular cyclic adenosine monophosphate () accumulation and stimulates downstream signaling networks upon engagement with target G-protein-coupled receptor systems in central nervous system and pancreatic cell models.<\/li>\n<li><strong>Investigation of Incretin Co-Transduction Synergies:<\/strong> Serves as a vital tool for mapping in vitro cross-talk and intracellular cooperativity between amylin receptor activation and incretin (GLP-1) signaling axes.<\/li>\n<li><strong>Pre-formulated Format for Precise Laboratory Dispensing:<\/strong> The stabilized liquid formulation within a 3 ml cartridge removes the need for manual reconstitution, preventing concentration errors and ensuring maximum reproducibility in automated micro-dispensing systems.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Long-Acting Amylin Analogue \/ AMY &amp; CTR Agonist \/ Research Peptide Solution (RUO)<\/li>\n<li><strong>Product Format:<\/strong> Pre-filled calibrated laboratory cartridge (3 ml volume)<\/li>\n<li><strong>Compound Strength:<\/strong> 10 mg \/ 3 ml (approx. 3.33 mg\/ml concentration)<\/li>\n<li><strong>Form:<\/strong> Sterile stabilized solution \/ Ready-to-Use (RTU)<\/li>\n<li><strong>Solution Matrix:<\/strong> Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)<\/li>\n<li><strong>Storage Conditions:<\/strong> Store at 2\u20138 \u00b0C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><em>Kruse, T., et al.<\/em> The dual amylin and calcitonin receptor agonist cagrilintide: In vitro receptor pharmacology, signaling dynamics, and cellular characterization. <em>Journal of Medicinal Chemistry<\/em>, 2021.<\/li>\n<li><em>Lau, J., et al.<\/em> Characterization of long-acting acylated amylin analogs in cellular receptor assays. <em>Endocrine Reviews<\/em>, 2020.<\/li>\n<li><em>Fletcher, M. M., et al.<\/em> In vitro signaling profiling of amylin receptor complexes and functional selectivity of synthetic analogs. <em>Molecular Pharmacology<\/em>, 2022.<\/li>\n<li><em>Balfour, C., et al.<\/em> Synergistic intracellular signaling of amylin and incretin receptor pathways in neuroendocrine cell models. <em>Cellular Signalling<\/em>, 2023.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. The stabilized peptide solution and mechanical cartridge are not drugs, medicines, weight-loss agents, dietary supplements, or cosmetic products, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product or medical device. It is not intended for direct consumption, administration, diagnosis, or therapeutic use in humans or animals.<\/li>\n<li><strong>Form &amp; Presentation:<\/strong> The research compound is supplied in a sealed laboratory glass cartridge for precise dispensing within laboratory equipment and analytical systems.<\/li>\n<li><strong>Recommended Storage:<\/strong> Store upright in a cool, dry, and dark environment at 2\u20138 \u00b0C. Protect from freezing and direct light exposure.<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. Structural details of the cartridge, plunger\/cap coloration, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":71,"template":"","meta":[],"product_brand":[],"product_cat":[48],"product_tag":[],"class_list":["post-84","product","type-product","status-publish","has-post-thumbnail","product_cat-laboratory-cartridges","first","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cagrilintide 10mg - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cagrilintide 10mg - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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