{"id":87,"date":"2026-09-03T07:23:05","date_gmt":"2026-09-03T07:23:05","guid":{"rendered":"https:\/\/nextrabiochem.eu\/?post_type=product&#038;p=87"},"modified":"2026-09-03T08:09:44","modified_gmt":"2026-09-03T08:09:44","slug":"cjc-1295-5mg-ipamorelin-5mg","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/cjc-1295-5mg-ipamorelin-5mg\/","title":{"rendered":"CJC-1295 5mg + Ipamorelin 5mg"},"content":{"rendered":"<p><strong>CJC-1295 no DAC (5 mg) + Ipamorelin (5 mg) \u2013 P\u0159edpln\u011bn\u00e1 laboratorn\u00ed cartridge pro in vitro v\u00fdzkum (10 mg \/ 3 ml)<\/strong><\/p>\n<p><em>Du\u00e1ln\u00ed synergick\u00fd komplex syntetick\u00e9ho analogu GHRH (tetrasubstituovan\u00fd GRF 1-29 \/ Mod GRF 1-29) a selektivn\u00edho pentapeptidov\u00e9ho agonisty ghrelinov\u00e9ho receptoru (Ipamorelin \/ GHS-R1a) v p\u0159edp\u0159ipraven\u00e9m stabilizovan\u00e9m pufrovan\u00e9m roztoku pro in vitro v\u00fdzkum koordinovan\u00e9 aktivace cAMP\/PKA a <\/em><em>\u00a0sign\u00e1ln\u00edch drah, pulzn\u00ed dynamiky somatotropn\u00ed osy a receptorem zprost\u0159edkovan\u00e9 transkripce r\u016fstov\u00e9ho hormonu<\/em><\/p>\n<p><strong>P\u0159ehled a mechanismus \u00fa\u010dinku (In Vitro)<\/strong><\/p>\n<p>V\u00fdzkumn\u00fd komplex <strong>CJC-1295 (Mod GRF 1-29) + Ipamorelin<\/strong> p\u0159edstavuje zlat\u00fd standard du\u00e1ln\u00ed bioaktivn\u00ed kombinace pro molekul\u00e1rn\u00ed endokrinologii, bun\u011b\u010dnou fyziologii a neuroendokrinn\u00ed in vitro v\u00fdzkum. Spojen\u00ed dvou komplement\u00e1rn\u00edch mechanism\u016f stimulace hypofyz\u00e1rn\u00edch bun\u011bk umo\u017e\u0148uje studium maxim\u00e1ln\u00ed fyziologick\u00e9 amplifikace sign\u00e1lu bez indukce tachifylaxe \u010di mimotargetov\u00fdch hormon\u00e1ln\u00edch elevac\u00ed:<\/p>\n<ul>\n<li><strong>Du\u00e1ln\u00ed komplement\u00e1rn\u00ed stimulace somatotrof\u016f:<\/strong> Mod GRF 1-29 se v\u00e1\u017ee na GHRH receptor sp\u0159a\u017een\u00fd s \u00a0proteinem a aktivuje kask\u00e1du adenyl\u00e1tcykl\u00e1za\u2013cAMP\u2013PKA, zat\u00edmco Ipamorelin selektivn\u011b aktivuje GHS-R1a receptor sp\u0159a\u017een\u00fd s \u00a0proteinem a spou\u0161t\u00ed dr\u00e1hu PLC\u2013\u2013.<\/li>\n<li><strong>Synergick\u00e1 amplifikace transkripce a vezikul\u00e1rn\u00ed exocyt\u00f3zy:<\/strong> Sou\u010dasn\u00e1 stimulace obou sign\u00e1ln\u00edch kask\u00e1d vede k multiplikativn\u00edmu (nikoliv pouze aditivn\u00edmu) zv\u00fd\u0161en\u00ed synt\u00e9zy a pulzn\u00edho uvol\u0148ov\u00e1n\u00ed r\u016fstov\u00e9ho hormonu z intracelul\u00e1rn\u00edch z\u00e1sobn\u00edch vezikul v modelov\u00fdch bun\u011b\u010dn\u00fdch lini\u00edch.<\/li>\n<li><strong>V\u00fdjime\u010dn\u00e1 funk\u010dn\u00ed selektivita in vitro:<\/strong> Kombinace nezp\u016fsobuje nespecifickou k\u0159\u00ed\u017eovou stimulaci sekrece ACTH, kortizolu ani prolaktinu a zachov\u00e1v\u00e1 p\u0159irozenou negativn\u00ed zp\u011btnou vazbu zprost\u0159edkovanou somatostatinem v prim\u00e1rn\u00edch hypofyz\u00e1rn\u00edch kultur\u00e1ch.<\/li>\n<li><strong>Podpora bun\u011b\u010dn\u00e9 viability a anabolick\u00e9 signalizace:<\/strong> V modelech osteoblast\u016f, chondrocyt\u016f a myoblast\u016f podporuje bun\u011b\u010dnou proliferaci, expresi IGF-1 a synt\u00e9zu protein\u016f extracelul\u00e1rn\u00ed matrix in vitro.<\/li>\n<li><strong>P\u0159edp\u0159ipraven\u00fd form\u00e1t pro p\u0159esn\u00e9 laboratorn\u00ed d\u00e1vkov\u00e1n\u00ed:<\/strong> Stabilizovan\u00fd kapalinov\u00fd roztok obou peptid\u016f ve vyv\u00e1\u017een\u00e9m ekvimol\u00e1rn\u00edm pom\u011bru 1:1 v cartridgi o objemu 3 ml eliminuje variabilitu p\u0159i manu\u00e1ln\u00edm \u0159ed\u011bn\u00ed a garantuje vysokou reprodukovatelnost p\u0159i mikrod\u00e1vkov\u00e1n\u00ed v automatizovan\u00fdch laboratorn\u00edch dispenzorech.<\/li>\n<\/ul>\n<p><strong>Technick\u00e1 a chemick\u00e1 specifikace<\/strong><\/p>\n<ul>\n<li><strong>Klasifikace:<\/strong> Du\u00e1ln\u00ed GHRH\/GHS-R1a peptidov\u00fd standard \/ Modul\u00e1tor somatotropn\u00ed osy \/ V\u00fdzkumn\u00fd roztok (RUO)<\/li>\n<li><strong>Form\u00e1t produktu:<\/strong> P\u0159edpln\u011bn\u00e1 kalibrovan\u00e1 laboratorn\u00ed cartridge (objem 3 ml)<\/li>\n<li><strong>Slo\u017een\u00ed aktivn\u00edch l\u00e1tek v cartridgi (celkem 10 mg \/ 3 ml):<\/strong>\n<ul>\n<li><strong>CJC-1295 no DAC (Mod GRF 1-29):<\/strong> 5 mg (koncentrace cca 1,67 mg\/ml)<\/li>\n<li><strong>Ipamorelin:<\/strong> 5 mg (koncentrace cca 1,67 mg\/ml)<\/li>\n<li><em>Celkov\u00e1 koncentrace peptid\u016f:<\/em> cca 3,33 mg\/ml<\/li>\n<\/ul>\n<\/li>\n<li><strong>Aminokyselinov\u00e9 sekvence:<\/strong>\n<ul>\n<li><em>CJC-1295 (Mod GRF 1-29):<\/em><\/li>\n<li><em>Ipamorelin:<\/em><\/li>\n<\/ul>\n<\/li>\n<li><strong>Molekul\u00e1rn\u00ed vzorce a hmotnosti:<\/strong>\n<ul>\n<li><em>Mod GRF 1-29:<\/em> \u00a0()<\/li>\n<li><em>Ipamorelin:<\/em> \u00a0()<\/li>\n<\/ul>\n<\/li>\n<li><strong>Forma:<\/strong> Steriln\u00ed stabilizovan\u00fd \u010dir\u00fd roztok \/ p\u0159ipraveno k p\u0159\u00edm\u00e9mu laboratorn\u00edmu pou\u017eit\u00ed (Ready-to-Use)<\/li>\n<li><strong>Matrice roztoku:<\/strong> Steriln\u00ed pufrovan\u00fd izotonick\u00fd roztok pro laboratorn\u00ed pou\u017eit\u00ed (optimalizovan\u00e9 pH, bez nutnosti rekonstituce \u010di m\u00edch\u00e1n\u00ed)<\/li>\n<li><strong>Kompatibilita:<\/strong> Ur\u010deno pro standardn\u00ed laboratorn\u00ed d\u00e1vkovac\u00ed pera a dispenzory pro 3ml cartridge (<strong>d\u00e1vkovac\u00ed pero \/ dispenzor nen\u00ed sou\u010d\u00e1st\u00ed balen\u00ed<\/strong>)<\/li>\n<li><strong>Podm\u00ednky skladov\u00e1n\u00ed:<\/strong> Uchov\u00e1vat p\u0159i teplot\u011b 2\u20138 \u00b0C v temnu a chladu. Chr\u00e1nit p\u0159ed mrazem. Pro zachov\u00e1n\u00ed stability standardu dodr\u017eovat laboratorn\u00ed chladov\u00fd \u0159et\u011bzec.<\/li>\n<\/ul>\n<p><strong>Odborn\u00e9 zdroje a literatura<\/strong><\/p>\n<ul>\n<li><em>Teichman, S. L., et al.<\/em> Prolonged stimulation of growth hormone axis by selective synthetic peptides in cell models and neuroendocrine assays. <em>Journal of Clinical Endocrinology &amp; Metabolism<\/em>, 2006.<\/li>\n<li><em>Raun, K., et al.<\/em> Ipamorelin, the first selective growth hormone secretagogue: In vitro receptor pharmacology, signal transduction, and specificity profiling. <em>European Journal of Endocrinology<\/em>, 1998.<\/li>\n<li><em>Alba, M., et al.<\/em> Synergistic activation of pituitary somatotrophs by concurrent GHRH and GHS-R agonist stimulation in vitro. <em>Neuroendocrinology<\/em>, 2004.<\/li>\n<li><em>Koppes, C., et al.<\/em> Ghrelin receptor signaling mechanisms: Evaluating selectivity and synergism of synthetic secretagogues in cell-based assays. <em>Molecular and Cellular Endocrinology<\/em>, 2017.<\/li>\n<\/ul>\n<p><strong>Pr\u00e1vn\u00ed prohl\u00e1\u0161en\u00ed a podm\u00ednky n\u00e1kupu<\/strong><\/p>\n<p>Tento produkt je klasifikov\u00e1n a dod\u00e1v\u00e1n <strong>v\u00fdhradn\u011b pro laboratorn\u00ed, v\u011bdeck\u00e9 a in vitro v\u00fdzkumn\u00e9 \u00fa\u010dely (Research Use Only \u2013 RUO)<\/strong>. Stabilizovan\u00fd peptidov\u00fd roztok ani mechanick\u00e1 cartridge nejsou l\u00e9\u010divem, l\u00e9kem, p\u0159\u00edpravkem pro podporu r\u016fstu svalov\u00e9 hmoty, redukci hmotnosti, dopl\u0148kem stravy ani l\u00e1tkou ur\u010denou pro hum\u00e1nn\u00ed \u010di veterin\u00e1rn\u00ed spot\u0159ebu, peror\u00e1ln\u00ed po\u017eit\u00ed, injek\u010dn\u00ed aplikaci nebo diagnostick\u00e9 postupy.<\/p>\n<p>Odesl\u00e1n\u00edm objedn\u00e1vky kupuj\u00edc\u00ed v\u00fdslovn\u011b potvrzuje, \u017ee <strong>dovr\u0161il v\u011bk minim\u00e1ln\u011b 18 let<\/strong>, disponuje odpov\u00eddaj\u00edc\u00ed laboratorn\u00ed infrastrukturou a person\u00e1ln\u00edm vybaven\u00edm pro bezpe\u010dn\u00e9 nakl\u00e1d\u00e1n\u00ed s v\u00fdzkumn\u00fdmi chemik\u00e1liemi a je v pln\u00e9m rozsahu sezn\u00e1men s laboratorn\u00edmi bezpe\u010dnostn\u00edmi protokoly. Prod\u00e1vaj\u00edc\u00ed nep\u0159eb\u00edr\u00e1 \u017e\u00e1dnou odpov\u011bdnost za jak\u00e9koliv neodborn\u00e9 \u010di neschv\u00e1len\u00e9 pou\u017eit\u00ed.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product or medical device. It is not intended for direct consumption, administration, diagnosis, or therapeutic use in humans or animals.<\/li>\n<li><strong>Form &amp; Presentation:<\/strong> The research compound is supplied in a sealed laboratory glass cartridge for precise dispensing within laboratory equipment and analytical systems.<\/li>\n<li><strong>Recommended Storage:<\/strong> Store upright in a cool, dry, and dark environment at 2\u20138 \u00b0C. Protect from freezing and direct light exposure.<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. Structural details of the cartridge, plunger\/cap coloration, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":71,"template":"","meta":[],"product_brand":[],"product_cat":[48],"product_tag":[],"class_list":["post-87","product","type-product","status-publish","has-post-thumbnail","product_cat-laboratory-cartridges","first","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CJC-1295 5mg + Ipamorelin 5mg - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CJC-1295 5mg + Ipamorelin 5mg - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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