{"id":91,"date":"2026-09-03T07:24:33","date_gmt":"2026-09-03T07:24:33","guid":{"rendered":"https:\/\/nextrabiochem.eu\/?post_type=product&#038;p=91"},"modified":"2026-09-03T09:15:39","modified_gmt":"2026-09-03T09:15:39","slug":"glp-3-r3t","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/glp-3-r3t\/","title":{"rendered":"GLP-3 R3T"},"content":{"rendered":"<p><strong>GLP-3 \/ R3T \u2013 Pre-filled Laboratory Cartridge for In Vitro Research (10 mg or 20 mg \/ 3 ml)<\/strong><\/p>\n<p><em>Synthetic tri-agonist research peptide of GLP-1, GIP, and glucagon (GCGR) receptors in a pre-formulated stabilized buffered solution for in vitro research on receptor dimerization, intracellular cAMP signaling, lipid metabolic flux, and mitochondrial bioenergetics<\/em><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>GLP-3 \/ R3T<\/strong> is an advanced synthetic acylated peptide engineered for experimental biology and laboratory research into multi-receptor signaling networks. In molecular endocrinology, it serves as a primary reference standard for investigating coordinated triple activation of metabolic pathways in cell culture models:<\/p>\n<ul>\n<li><strong>Simultaneous Activation of GLP-1R, GIPR, and GCGR:<\/strong> Exhibits balanced binding affinity across the glucagon-like peptide-1 receptor (GLP-1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GCGR), enabling detailed mapping of synergistic receptor complex activation in vitro.<\/li>\n<li><strong>Modulation of the Adenylate Cyclase and cAMP Cascade:<\/strong> Upon binding to -coupled receptors, it stimulates intracellular cyclic adenosine monophosphate () synthesis and downstream protein kinase A (PKA) activation in experimental cell models.<\/li>\n<li><strong>Stimulation of Lipid Oxidation &amp; Metabolic Flux In Vitro:<\/strong> Direct activation of glucagon receptors in hepatocyte and adipocyte cell lines triggers enzymatic pathways governing fatty acid -oxidation and thermogenic marker expression (UCP-1).<\/li>\n<li><strong>Pre-formulated Format for Precise Laboratory Dispensing:<\/strong> The stabilized liquid matrix within a 3 ml cartridge eliminates manual reconstitution variability, ensuring exceptional homogeneity and concentration consistency for micro-dispensing in automated and semi-automated laboratory systems.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Tri-Agonist of GLP-1R \/ GIPR \/ GCGR \/ Research Peptide Solution (RUO)<\/li>\n<li><strong>Product Format:<\/strong> Pre-filled calibrated laboratory cartridge (3 ml volume)<\/li>\n<li><strong>Available Strength Variants:<\/strong>\n<ul>\n<li>10 mg \/ 3 ml (approx. 3.33 mg\/ml concentration)<\/li>\n<li>20 mg \/ 3 ml (approx. 6.67 mg\/ml concentration)<\/li>\n<\/ul>\n<\/li>\n<li><strong>Form:<\/strong> Sterile stabilized solution \/ Ready-to-Use (RTU)<\/li>\n<li><strong>Solution Matrix:<\/strong> Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)<\/li>\n<li><strong>Storage Conditions:<\/strong> Store at 2\u20138 \u00b0C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><em>Coskun, T., et al.<\/em> A novel triple GIP, GLP-1, and glucagon receptor agonist: In vitro receptor activation, signaling profiles, and metabolic characterization. <em>Cell Metabolism<\/em>, 2022.<\/li>\n<li><em>Urva, S., et al.<\/em> In vitro signaling dynamics and downstream transcription patterns of triple incretin receptor agonists. <em>Molecular Metabolism<\/em>, 2023.<\/li>\n<li><em>Jall, S., et al.<\/em> Synergistic receptor pharmacology: Dissecting the individual contributions of GIP, GLP-1, and glucagon in cellular models. <em>Nature Communications<\/em>, 2021.<\/li>\n<li><em>Finan, B., et al.<\/em> Multireceptor endocrine pharmacology: Molecular engineering and in vitro profiling of monomeric peptides. <em>Endocrine Reviews<\/em>, 2020.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. The stabilized peptide solution and mechanical cartridge are not drugs, medicines, weight-loss agents, dietary supplements, or cosmetic products, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product or medical device. It is not intended for direct consumption, administration, diagnosis, or therapeutic use in humans or animals.<\/li>\n<li><strong>Form &amp; Presentation:<\/strong> The research compound is supplied in a sealed laboratory glass cartridge for precise dispensing within laboratory equipment and analytical systems.<\/li>\n<li><strong>Recommended Storage:<\/strong> Store upright in a cool, dry, and dark environment at 2\u20138 \u00b0C. Protect from freezing and direct light exposure.<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. Structural details of the cartridge, plunger\/cap coloration, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":71,"template":"","meta":[],"product_brand":[],"product_cat":[48],"product_tag":[],"class_list":["post-91","product","type-product","status-publish","has-post-thumbnail","product_cat-laboratory-cartridges","first","instock","shipping-taxable","purchasable","product-type-variable","has-default-attributes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>GLP-3 R3T - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"GLP-3 R3T - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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