{"id":92,"date":"2026-09-03T07:27:52","date_gmt":"2026-09-03T07:27:52","guid":{"rendered":"https:\/\/nextrabiochem.eu\/?post_type=product&#038;p=92"},"modified":"2026-09-03T09:17:05","modified_gmt":"2026-09-03T09:17:05","slug":"ipamorelin-10mg","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/ipamorelin-10mg\/","title":{"rendered":"Ipamorelin 10mg"},"content":{"rendered":"<p><strong>Ipamorelin \u2013 Pre-filled Laboratory Cartridge for In Vitro Research (10 mg \/ 3 ml)<\/strong><\/p>\n<p><em>Synthetic selective pentapeptide agonist of the growth hormone secretagogue receptor (GHS-R1a) in a pre-formulated stabilized buffered solution for in vitro research on intracellular <\/em><em>\u00a0signaling dynamics, somatotropic pulsatility, and receptor binding selectivity<\/em><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>Ipamorelin<\/strong> is a synthetic bioactive pentapeptide belonging to the growth hormone secretagogue (GHRP) class. In molecular endocrinology, cellular physiology, and receptor pharmacology, it serves as a primary reference standard for investigating selective growth hormone secretagogue receptor (GHS-R1a) activation without off-target neuroendocrine interference across cultured cell models:<\/p>\n<ul>\n<li><strong>High-Affinity Selective GHS-R1a Agonism:<\/strong> Displays specific binding affinity toward the -coupled GHS-R1a receptor, stimulating phospholipase C (PLC), inositol trisphosphate () accumulation, and intracellular calcium () mobilization in pituitary cell models.<\/li>\n<li><strong>Exceptional Functional Selectivity In Vitro:<\/strong> Unlike earlier generation secretagogues (such as GHRP-2 or GHRP-6), it does not induce significant cross-activation of ACTH, cortisol, or prolactin secretion in cultured neuroendocrine systems, providing a pure model for somatotropic axis mapping.<\/li>\n<li><strong>Modulation of Proliferation and Anabolic Pathways:<\/strong> Stimulates cell proliferation, differentiation marker expression, and extracellular matrix synthesis in primary osteoblast and chondrocyte cultures via downstream signaling networks.<\/li>\n<li><strong>Pre-formulated Format for Precise Laboratory Dispensing:<\/strong> The stabilized liquid formulation within a 3 ml cartridge eliminates manual reconstitution steps, preventing concentration errors and ensuring maximum reproducibility across automated micro-dispensing platforms.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Selective GHS-R1a Agonist \/ GHRP Analogue \/ Research Peptide Solution (RUO)<\/li>\n<li><strong>Product Format:<\/strong> Pre-filled calibrated laboratory cartridge (3 ml volume)<\/li>\n<li><strong>Compound Strength:<\/strong> 10 mg \/ 3 ml (approx. 3.33 mg\/ml concentration)<\/li>\n<li><strong>Amino Acid Sequence:<\/strong> Aib-His-D-2-Nal-D-Phe-Lys-<\/li>\n<li><strong>Chemical Name:<\/strong><\/li>\n<li><strong>Molecular Formula:<\/strong><\/li>\n<li><strong>Molecular Weight:<\/strong><\/li>\n<li><strong>Form:<\/strong> Sterile stabilized solution \/ Ready-to-Use (RTU)<\/li>\n<li><strong>Solution Matrix:<\/strong> Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)<\/li>\n<li><strong>Compatibility:<\/strong> Compatible with standard laboratory dispensing pens and micro-dispensers for 3 ml cartridges (<strong>dispensing pen\/injector is not included in the package<\/strong>)<\/li>\n<li><strong>Storage Conditions:<\/strong> Store at 2\u20138 \u00b0C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><em>Raun, K., et al.<\/em> Ipamorelin, the first selective growth hormone secretagogue: In vitro receptor pharmacology, signal transduction, and specificity profiling. <em>European Journal of Endocrinology<\/em>, 1998.<\/li>\n<li><em>Koppes, C., et al.<\/em> Ghrelin receptor signaling mechanisms: Evaluating selectivity of synthetic secretagogues in cell-based assays. <em>Molecular and Cellular Endocrinology<\/em>, 2017.<\/li>\n<li><em>Svensson, J., et al.<\/em> The growth hormone secretagogue ipamorelin stimulates longitudinal bone growth and osteoblast activity in vitro and in cell models. <em>Journal of Endocrinology<\/em>, 2000.<\/li>\n<li><em>Venanzi, F., et al.<\/em> Molecular dynamics of GHS-R1a activation and intracellular calcium mobilization in neuroendocrine cell lines. <em>Biochemical Pharmacology<\/em>, 2015.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. The stabilized peptide solution and mechanical cartridge are not drugs, medicines, muscle-building agents, weight-loss products, dietary supplements, or medical devices, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product or medical device. It is not intended for direct consumption, administration, diagnosis, or therapeutic use in humans or animals.<\/li>\n<li><strong>Form &amp; Presentation:<\/strong> The research compound is supplied in a sealed laboratory glass cartridge for precise dispensing within laboratory equipment and analytical systems.<\/li>\n<li><strong>Recommended Storage:<\/strong> Store upright in a cool, dry, and dark environment at 2\u20138 \u00b0C. Protect from freezing and direct light exposure.<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. Structural details of the cartridge, plunger\/cap coloration, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":71,"template":"","meta":[],"product_brand":[],"product_cat":[48],"product_tag":[],"class_list":["post-92","product","type-product","status-publish","has-post-thumbnail","product_cat-laboratory-cartridges","first","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ipamorelin 10mg - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ipamorelin 10mg - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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