{"id":93,"date":"2026-09-03T07:28:43","date_gmt":"2026-09-03T07:28:43","guid":{"rendered":"https:\/\/nextrabiochem.eu\/?post_type=product&#038;p=93"},"modified":"2026-09-03T09:18:32","modified_gmt":"2026-09-03T09:18:32","slug":"kisspeptin-10mg","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/kisspeptin-10mg\/","title":{"rendered":"Kisspeptin 10mg"},"content":{"rendered":"<p><strong>Kisspeptin-10 \u2013 Pre-filled Laboratory Cartridge for In Vitro Research (10 mg \/ 3 ml)<\/strong><\/p>\n<p><em>Synthetic bioactive decapeptide and high-affinity agonist of the metastin\/KISS1 receptor (KISS1R \/ GPR54) in a pre-formulated stabilized buffered solution for in vitro research on <\/em><em>\u00a0signaling cascades, intracellular <\/em><em>\u00a0mobilization, GnRH secretion dynamics, and gonadotropic axis regulation<\/em><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>Kisspeptin-10<\/strong> is a synthetic decapeptide representing the core biologically active C-terminal sequence of endogenous metastin (the product of the <em>KISS1<\/em> gene). In cellular biology, molecular endocrinology, and reproductive sciences, it serves as a primary reference standard for investigating upstream hypothalamic-pituitary-gonadal (HPG) axis regulation and KISS1R receptor pharmacology:<\/p>\n<ul>\n<li><strong>Selective KISS1R (GPR54) Receptor Activation:<\/strong> Binds with nanomolar affinity to the -coupled KISS1R receptor, activating phospholipase C (PLC), stimulating inositol trisphosphate () and diacylglycerol (DAG) production, and inducing robust intracellular calcium () mobilization in neuronal cell lines.<\/li>\n<li><strong>Direct Stimulation of GnRH Neuronal Depolarization:<\/strong> Triggers membrane depolarization and pulsatile exocytosis of gonadotropin-releasing hormone (GnRH) in primary hypothalamic cell cultures and GT1-7 neuronal models.<\/li>\n<li><strong>Regulation of Downstream Gonadotropin Expression:<\/strong> Upregulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) subunit transcription in pituitary cell cultures via MAPK\/ERK and p38 signaling networks in vitro.<\/li>\n<li><strong>Modulation of Cell Motility &amp; Anti-Metastatic Signaling:<\/strong> Regulates actin cytoskeletal reorganization and suppresses cell migration and extracellular matrix invasion in model cancer cell lines in vitro.<\/li>\n<li><strong>Pre-formulated Format for Precise Laboratory Dispensing:<\/strong> The stabilized liquid matrix within a 3 ml cartridge eliminates manual reconstitution steps, ensuring exceptional homogeneity and concentration consistency for automated micro-dispensing systems.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> KISS1R (GPR54) Agonist \/ Neuroendocrine Gonadotropic Modulator \/ Research Solution (RUO)<\/li>\n<li><strong>Product Format:<\/strong> Pre-filled calibrated laboratory cartridge (3 ml volume)<\/li>\n<li><strong>Compound Strength:<\/strong> 10 mg \/ 3 ml (approx. 3.33 mg\/ml concentration)<\/li>\n<li><strong>Amino Acid Sequence:<\/strong> Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-<\/li>\n<li><strong>Chemical Name:<\/strong> Kisspeptin-10 (metastin 45-54 amide)<\/li>\n<li><strong>Molecular Formula:<\/strong><\/li>\n<li><strong>Molecular Weight:<\/strong><\/li>\n<li><strong>Form:<\/strong> Sterile stabilized clear solution \/ Ready-to-Use (RTU)<\/li>\n<li><strong>Solution Matrix:<\/strong> Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)<\/li>\n<li><strong>Compatibility:<\/strong> Compatible with standard laboratory dispensing pens and micro-dispensers for 3 ml cartridges (<strong>dispensing pen\/injector is not included in the package<\/strong>)<\/li>\n<li><strong>Storage Conditions:<\/strong> Store at 2\u20138 \u00b0C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><em>Kotani, M., et al.<\/em> The metastasis suppressor gene KISS-1 encodes kisspeptins, the natural ligands of the orphan G-protein-coupled receptor GPR54: In vitro pharmacology and signaling. <em>Journal of Biological Chemistry<\/em>, 2001.<\/li>\n<li><em>Messager, S., et al.<\/em> Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54 in hypothalamic cell models. <em>Proceedings of the National Academy of Sciences<\/em>, 2005.<\/li>\n<li><em>Castellano, J. M., et al.<\/em> Mechanisms of kisspeptin-10 activation of the gonadotropic axis: In vitro characterization of downstream LH\/FSH secretion. <em>Endocrinology<\/em>, 2006.<\/li>\n<li><em>Casta\u00f1o, J. P., et al.<\/em> Intracellular signaling pathways mediating kisspeptin stimulation of pituitary and hypothalamic cells in vitro. <em>Frontiers in Endocrinology<\/em>, 2014.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. The stabilized peptide solution and mechanical cartridge are not drugs, medicines, fertility therapies, testosterone boosters, dietary supplements, or medical devices, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product or medical device. It is not intended for direct consumption, administration, diagnosis, or therapeutic use in humans or animals.<\/li>\n<li><strong>Form &amp; Presentation:<\/strong> The research compound is supplied in a sealed laboratory glass cartridge for precise dispensing within laboratory equipment and analytical systems.<\/li>\n<li><strong>Recommended Storage:<\/strong> Store upright in a cool, dry, and dark environment at 2\u20138 \u00b0C. Protect from freezing and direct light exposure.<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. Structural details of the cartridge, plunger\/cap coloration, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":71,"template":"","meta":[],"product_brand":[],"product_cat":[48],"product_tag":[],"class_list":["post-93","product","type-product","status-publish","has-post-thumbnail","product_cat-laboratory-cartridges","first","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Kisspeptin 10mg - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kisspeptin 10mg - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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