{"id":95,"date":"2026-09-03T07:29:21","date_gmt":"2026-09-03T07:29:21","guid":{"rendered":"https:\/\/nextrabiochem.eu\/?post_type=product&#038;p=95"},"modified":"2026-09-03T09:21:52","modified_gmt":"2026-09-03T09:21:52","slug":"melanotan-ii-10mg","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/en\/produkt\/melanotan-ii-10mg\/","title":{"rendered":"Melanotan II 10mg"},"content":{"rendered":"<p><strong>Melanotan II \u2013 Pre-filled Laboratory Cartridge for In Vitro Research (10 mg \/ 3 ml)<\/strong><\/p>\n<p><em>Synthetic cyclic <\/em><em>-MSH analogue and non-selective melanocortin receptor agonist (MC1R\u2013MC5R) in a pre-formulated stabilized buffered solution for in vitro research on melanogenesis pathways, intracellular cAMP cascades, and receptor binding pharmacology<\/em><\/p>\n<p><strong>Overview &amp; Mechanism of Action (In Vitro)<\/strong><\/p>\n<p><strong>Melanotan II<\/strong> (MT-II) is a synthetic cyclic heptapeptide analogue derived from the endogenous melanocyte-stimulating hormone (-MSH). In cell biology, experimental dermatology, and molecular pharmacology, it serves as a primary reference standard for investigating melanocortin signaling networks and receptor selectivity across cultured cell models:<\/p>\n<ul>\n<li><strong>Non-Selective Melanocortin Receptor Engagement (MC1R, MC3R, MC4R, MC5R):<\/strong> Displays high binding affinity across the G-protein-coupled receptor family (), facilitating comparative in vitro profiling of receptor kinetics and downstream signal transduction.<\/li>\n<li><strong>Stimulation of the Adenylate Cyclase and cAMP Cascade:<\/strong> Triggers robust intracellular cyclic adenosine monophosphate () accumulation and subsequent protein kinase A (PKA) activation upon receptor engagement in experimental cell lines.<\/li>\n<li><strong>Modulation of the Melanogenic Transcription Axis (MITF \/ Tyrosinase):<\/strong> In primary and cultured melanocyte models, it promotes microphthalmia-associated transcription factor (MITF) activation, upregulating tyrosinase enzyme expression and eumelanin synthesis in vitro.<\/li>\n<li><strong>Pre-formulated Format for Precise Laboratory Dispensing:<\/strong> The stabilized liquid formulation within a 3 ml cartridge eliminates manual reconstitution variability, ensuring exceptional homogeneity and concentration consistency for automated and semi-automated micro-dispensing systems.<\/li>\n<\/ul>\n<p><strong>Technical &amp; Chemical Specifications<\/strong><\/p>\n<ul>\n<li><strong>Classification:<\/strong> Cyclic Melanocortin Analogue \/ MC1R\u2013MC5R Agonist \/ Research Peptide Solution (RUO)<\/li>\n<li><strong>Product Format:<\/strong> Pre-filled calibrated laboratory cartridge (3 ml volume)<\/li>\n<li><strong>Compound Strength:<\/strong> 10 mg \/ 3 ml (approx. 3.33 mg\/ml concentration)<\/li>\n<li><strong>Amino Acid Sequence:<\/strong> Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-<\/li>\n<li><strong>Molecular Formula:<\/strong><\/li>\n<li><strong>Molecular Weight:<\/strong><\/li>\n<li><strong>Form:<\/strong> Sterile stabilized solution \/ Ready-to-Use (RTU)<\/li>\n<li><strong>Solution Matrix:<\/strong> Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)<\/li>\n<li><strong>Compatibility:<\/strong> Compatible with standard laboratory dispensing pens and micro-dispensers for 3 ml cartridges (<strong>dispensing pen\/injector is not included in the package<\/strong>)<\/li>\n<li><strong>Storage Conditions:<\/strong> Store at 2\u20138 \u00b0C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.<\/li>\n<\/ul>\n<p><strong>Scientific References &amp; Literature<\/strong><\/p>\n<ul>\n<li><em>Hadley, M. E., et al.<\/em> Discovery and development of novel melanocortin receptor agonists: In vitro pharmacology and melanogenic profiling. <em>Journal of Investigative Dermatology<\/em>, 1998.<\/li>\n<li><em>Dorval, B. L., et al.<\/em> Cyclic melanocortin peptides: In vitro receptor binding kinetics and downstream cAMP accumulation in cellular assays. <em>Peptides<\/em>, 2002.<\/li>\n<li><em>Schi\u00f6th, H. B., et al.<\/em> Characterization of the binding of melanocortin receptor agonists across MC1R to MC5R subtypes in vitro. <em>European Journal of Pharmacology<\/em>, 1997.<\/li>\n<li><em>Hunt, G., et al.<\/em> Signaling mechanisms of alpha-MSH and synthetic analogs in cultured human melanocytes. <em>Cellular Signalling<\/em>, 2000.<\/li>\n<\/ul>\n<p><strong>Legal Disclaimer &amp; Terms of Purchase<\/strong><\/p>\n<p>This product is classified and supplied <strong>strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only \u2013 RUO)<\/strong>. The stabilized peptide solution and mechanical cartridge are not drugs, medicines, tanning products, cosmetic formulations, dietary supplements, or medical devices, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.<\/p>\n<p>By placing an order, the purchaser explicitly confirms that they are <strong>at least 18 years of age<\/strong>, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Intended Use:<\/strong> This product is supplied <strong>strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro)<\/strong>. It is not a medicinal product or medical device. It is not intended for direct consumption, administration, diagnosis, or therapeutic use in humans or animals.<\/li>\n<li><strong>Form &amp; Presentation:<\/strong> The research compound is supplied in a sealed laboratory glass cartridge for precise dispensing within laboratory equipment and analytical systems.<\/li>\n<li><strong>Recommended Storage:<\/strong> Store upright in a cool, dry, and dark environment at 2\u20138 \u00b0C. Protect from freezing and direct light exposure.<\/li>\n<li><strong>Illustrative Product Image:<\/strong> Product images are for <strong>illustrative purposes only<\/strong>. Structural details of the cartridge, plunger\/cap coloration, or laboratory label design may vary depending on the production batch.<\/li>\n<\/ul>\n","protected":false},"featured_media":71,"template":"","meta":[],"product_brand":[],"product_cat":[48],"product_tag":[],"class_list":["post-95","product","type-product","status-publish","has-post-thumbnail","product_cat-laboratory-cartridges","first","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Melanotan II 10mg - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Melanotan II 10mg - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only \/ in vitro). 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