{"id":1983,"date":"2026-09-11T08:15:52","date_gmt":"2026-09-11T08:15:52","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/cjc-1295-with-dac-5mg\/"},"modified":"2026-09-11T12:22:40","modified_gmt":"2026-09-11T12:22:40","slug":"cjc-1295-with-dac-5mg","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/es\/produkt\/cjc-1295-with-dac-5mg\/","title":{"rendered":"CJC-1295 with DAC 5mg"},"content":{"rendered":"<p><strong>CJC-1295 with DAC<\/strong><\/p>\n<p><i>An\u00e1logo sint\u00e9tico de la hormona liberadora de la hormona del crecimiento (GHRH) con tecnolog\u00eda Drug Affinity Complex para la investigaci\u00f3n in vitro de v\u00edas receptoras<\/i><\/p>\n<p><strong>Descripci\u00f3n general y mecanismo de acci\u00f3n (In Vitro)<\/strong><\/p>\n<p><strong>CJC-1295 with DAC<\/strong> (Drug Affinity Complex) es un an\u00e1logo sint\u00e9tico de 30 amino\u00e1cidos derivado del fragmento GHRH(1\u201329). En la investigaci\u00f3n bioqu\u00edmica y endocrinol\u00f3gica se utiliza para analizar la activaci\u00f3n selectiva del receptor de GHRH y la cin\u00e9tica de interacci\u00f3n prolongada con dianas celulares:<\/p>\n<ul>\n<li><strong>Activaci\u00f3n del receptor GHRH (GHRH-R):<\/strong> Uni\u00f3n a receptores acoplados a prote\u00ednas Gs en membranas de c\u00e9lulas somatotr\u00f3picas aisladas, estimulando la s\u00edntesis de AMPc y la v\u00eda de la prote\u00edna quinasa A (PKA).<\/li>\n<li><strong>Tecnolog\u00eda DAC (Drug Affinity Complex):<\/strong> La adici\u00f3n de un grupo \u00e1cido maleimidopropi\u00f3nico (MPA) en el extremo C-terminal permite la bioconjugaci\u00f3n covalente a grupos tiol (-SH) de la alb\u00famina (espec\u00edficamente en Cys34), protegiendo la estructura frente a la degradaci\u00f3n proteol\u00edtica r\u00e1pida.<\/li>\n<li><strong>Resistencia a la enzima DPP-4:<\/strong> Modificaciones en cuatro posiciones cr\u00edticas (D-Ala2, Gln8, Ala15, Leu27) confieren estabilidad frente al corte por dipeptidil peptidasa-4 en comparaci\u00f3n con la secuencia nativa.<\/li>\n<\/ul>\n<p>Esta optimizaci\u00f3n permite estudiar la estimulaci\u00f3n continua de se\u00f1ales intracelulares en cultivos celulares sin requerir administraciones repetidas.<\/p>\n<p><strong>Especificaciones t\u00e9cnicas y qu\u00edmicas<\/strong><\/p>\n<ul>\n<li><strong>Clasificaci\u00f3n:<\/strong> P\u00e9ptido de investigaci\u00f3n \/ An\u00e1logo de GHRH de acci\u00f3n prolongada (Agonista de GHRH-R)<\/li>\n<li><strong>Secuencia de amino\u00e1cidos:<\/strong> Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(MPA)-NH2<\/li>\n<li><strong>Forma:<\/strong> Polvo liofilizado blanco est\u00e9ril (liofilizado)<\/li>\n<li><strong>Identificaci\u00f3n del peso molecular:<\/strong> Confirmada mediante espectrometr\u00eda de masas (MS)<\/li>\n<li><strong>Disolvente de reconstituci\u00f3n recomendado:<\/strong> Agua bacteriost\u00e1tica est\u00e9ril o agua desionizada est\u00e9ril para laboratorio (evitar tampones fosfato b\u00e1sicos para prevenir la hidr\u00f3lisis prematura del grupo maleimida)<\/li>\n<li><strong>Condiciones de almacenamiento:<\/strong> Conservar a largo plazo a -20 \u00b0C en un lugar seco y protegido de la luz. Tras la reconstituci\u00f3n, mantener refrigerado a 2\u20138 \u00b0C y utilizar seg\u00fan el protocolo de laboratorio.<\/li>\n<\/ul>\n<p><strong>Referencias cient\u00edficas y literatura<\/strong><\/p>\n<ul>\n<li><i>Teichman, S. L., et al.<\/i> Prolonged stimulation of growth hormone axis by CJC-1295, a long-acting GHRH analog: Pharmacokinetic and pharmacodynamic characterization. <i>The Journal of Clinical Endocrinology &amp; Metabolism<\/i>, 2006.<\/li>\n<li><i>Jette, L., et al.<\/i> hGRF1-29-albumin bioconjugates activate the GHRH receptor in vitro and exhibit prolonged stability in biological media. <i>Endocrinology<\/i>, 2005.<\/li>\n<li><i>Alba, M., et al.<\/i> Once-weekly administration of CJC-1295: Evaluation of receptor dynamics and intracellular signaling pathways in model systems. <i>European Journal of Endocrinology<\/i>, 2006.<\/li>\n<li><i>Sackmann-Sala, L., et al.<\/i> GHRH and its synthetic derivatives: Comparative receptor kinetics and structural stability assays. <i>Growth Hormone &amp; IGF Research<\/i>, 2009.<\/li>\n<\/ul>\n<p><strong>Descargo legal y condiciones de compra<\/strong><\/p>\n<p>Este producto se distribuye <strong>exclusivamente para fines cient\u00edficos, anal\u00edticos y de investigaci\u00f3n in vitro (Research Use Only \u2013 RUO)<\/strong>. El compuesto no es un f\u00e1rmaco, medicamento, suplemento nutricional ni cosm\u00e9tico, y no est\u00e1 destinado al consumo humano o veterinario, administraci\u00f3n directa, inyecci\u00f3n ni uso diagn\u00f3stico.<\/p>\n<p>Al tramitar el pedido, el comprador declara expresamente ser <strong>mayor de 18 a\u00f1os<\/strong>, contar con la capacidad profesional e instalaciones necesarias para el manejo seguro de reactivos de investigaci\u00f3n y conocer en su totalidad las normativas de seguridad relativas a sustancias de ensayo. El vendedor no asume responsabilidad alguna por usos no autorizados.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>Uso previsto:<\/strong> Este producto se suministra <strong>exclusivamente para fines de laboratorio, cient\u00edficos y de investigaci\u00f3n (Research Use Only \/ in vitro)<\/strong>. No es un medicamento, alimento ni suplemento nutricional. La sustancia no est\u00e1 destinada al consumo, administraci\u00f3n ni uso terap\u00e9utico en humanos o animales.<\/li>\n<li><strong>Forma y contenido:<\/strong> Se suministra como polvo liofilizado est\u00e9ril en un vial de laboratorio sellado. No incluye disolvente de reconstituci\u00f3n a menos que se indique expresamente lo contrario.<\/li>\n<li><strong>Almacenamiento recomendado:<\/strong> Para mantener una estabilidad \u00f3ptima, conserve el vial sin abrir en un lugar fresco, seco y protegido de la luz a 2\u20138 \u00b0C (se recomienda -20 \u00b0C para almacenamiento prolongado).<\/li>\n<li><strong>Imagen ilustrativa:<\/strong> La imagen del producto es meramente <strong>ilustrativa<\/strong>. El aspecto final del vial, el color del tap\u00f3n desprendible (flip-off) o el dise\u00f1o de la etiqueta pueden variar seg\u00fan el lote de producci\u00f3n.<\/li>\n<\/ul>\n","protected":false},"featured_media":1984,"template":"","meta":[],"product_brand":[],"product_cat":[64],"product_tag":[],"class_list":["post-1983","product","type-product","status-publish","has-post-thumbnail","product_cat-sustancias-liofilizadas","first","instock","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CJC-1295 with DAC 5mg - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CJC-1295 with DAC 5mg - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"Uso previsto: Este producto se suministra exclusivamente para fines de laboratorio, cient\u00edficos y de investigaci\u00f3n (Research Use Only \/ in vitro). 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