{"id":1703,"date":"2026-09-11T08:58:33","date_gmt":"2026-09-11T08:58:33","guid":{"rendered":"https:\/\/nextrabiochem.eu\/produkt\/epithalon\/"},"modified":"2026-09-11T08:58:33","modified_gmt":"2026-09-11T08:58:33","slug":"epithalon","status":"publish","type":"product","link":"https:\/\/nextrabiochem.eu\/it\/produkt\/epithalon\/","title":{"rendered":"Epithalon"},"content":{"rendered":"<p><strong>Epithalon<\/strong><\/p>\n<p><i>Syntetick\u00fd tetrapeptid (Ala-Glu-Asp-Gly) pro in vitro v\u00fdzkum indukce exprese telomer\u00e1zy, prodlu\u017eov\u00e1n\u00ed telomer, regulace bun\u011b\u010dn\u00e9 senescence a epigenetick\u00e9 modulace<\/i><\/p>\n<p><strong>P\u0159ehled a mechanismus \u00fa\u010dinku (In Vitro)<\/strong><\/p>\n<p><strong>Epithalon<\/strong> (zn\u00e1m\u00fd tak\u00e9 jako <i>Epitalon<\/i> nebo <i>Epithalone<\/i>) je syntetick\u00fd ultra-kr\u00e1tk\u00fd peptid slo\u017een\u00fd ze \u010dty\u0159 aminokyselin se sekvenc\u00ed <i>(Ala-Glu-Asp-Gly)<\/i>. Byl vyvinut na z\u00e1klad\u011b bioaktivn\u00edho peptidov\u00e9ho extraktu z epif\u00fdzy (epithalaminu). V molekul\u00e1rn\u00ed gerontologii, bun\u011b\u010dn\u00e9 biologii a genetick\u00e9m v\u00fdzkumu slou\u017e\u00ed jako referen\u010dn\u00ed model pro studium mechanism\u016f bun\u011b\u010dn\u00e9ho st\u00e1rnut\u00ed a genomov\u00e9 integrity:<\/p>\n<ul>\n<li><strong>Indukce exprese telomer\u00e1zy (hTERT):<\/strong> Stimulace transkrip\u010dn\u00ed aktivity genu pro lidskou telomer\u00e1zovou reverzn\u00ed transkript\u00e1zu (hTERT), vedouc\u00ed k reaktivaci enzymu telomer\u00e1zy a prodlou\u017een\u00ed telomerick\u00fdch repetitivn\u00edch sekvenc\u00ed v somatick\u00fdch bun\u011b\u010dn\u00fdch lini\u00edch.<\/li>\n<li><strong>P\u0159ekon\u00e1n\u00ed Hayflickova limitu a supresie senescence:<\/strong> Zkoum\u00e1n\u00ed schopnosti peptidu odd\u00e1lit replikativn\u00ed st\u00e1rnut\u00ed bun\u011bk, zv\u00fd\u0161it prolifera\u010dn\u00ed kapacitu prim\u00e1rn\u00edch lidsk\u00fdch fibroblast\u016f a redukovat markery st\u00e1rnut\u00ed (senescence-associated \u03b2-galactosidase, SA-\u03b2-gal).<\/li>\n<li><strong>Epigenetick\u00e1 regulace a remodelace chromatinu:<\/strong> Vazba na specifick\u00e9 sekvence v DNA a interakce s histony, usnad\u0148uj\u00edc\u00ed dekondenzaci heterochromatinu a modulaci genov\u00e9 exprese spojen\u00e9 s opravami DNA.<\/li>\n<li><strong>Antioxida\u010dn\u00ed a neuroendokrinn\u00ed signalizace:<\/strong> Studium vlivu na expresi antioxida\u010dn\u00edch enzym\u016f (superoxiddismut\u00e1zy, glutathionperoxid\u00e1zy) a regulaci synt\u00e9zy melatoninu v bu\u0148k\u00e1ch pine\u00e1ln\u00ed \u017el\u00e1zy.<\/li>\n<\/ul>\n<p><strong>Technick\u00e1 a chemick\u00e1 specifikace<\/strong><\/p>\n<ul>\n<li><strong>Klasifikace:<\/strong> V\u00fdzkumn\u00fd tetrapeptid \/ Modul\u00e1tor telomer\u00e1zy a bun\u011b\u010dn\u00e9 senescence<\/li>\n<li><strong>Aminokyselinov\u00e1 sekvence:<\/strong> Ala-Glu-Asp-Gly (AEDG)<\/li>\n<li><strong>Forma:<\/strong> Steriln\u00ed lyofilizovan\u00fd b\u00edl\u00fd pr\u00e1\u0161ek (lyofiliz\u00e1t)<\/li>\n<li><strong>Identifikace:<\/strong> Ov\u011b\u0159ena hmotnostn\u00ed spektrometri\u00ed (MS) a analytickou HPLC<\/li>\n<li><strong>Doporu\u010den\u00e9 rozpou\u0161t\u011bdlo pro rekonstituci:<\/strong> Steriln\u00ed bakteriostatick\u00e1 voda nebo steriln\u00ed fyziologick\u00fd roztok (PBS)<\/li>\n<li><strong>Podm\u00ednky skladov\u00e1n\u00ed:<\/strong> Dlouhodob\u011b p\u0159i teplot\u011b -20 \u00b0C v suchu a temnu. Po rekonstituci uchov\u00e1vat v laboratorn\u00edm chlazen\u00ed p\u0159i 2\u20138 \u00b0C a spot\u0159ebovat v souladu s experiment\u00e1ln\u00edm protokolem.<\/li>\n<\/ul>\n<p><strong>Odborn\u00e9 zdroje a literatura<\/strong><\/p>\n<ul>\n<li><i>Khavinson, V. K., et al.<\/i> Synthetic peptide Epitalon stimulates telomerase activity and extends life span in human somatic cells in vitro. <i>Bulletin of Experimental Biology and Medicine<\/i>, 2003.<\/li>\n<li><i>Khavinson, V. K., et al.<\/i> Epigenetic aspects of peptide regulation of aging and gene expression. <i>Biogerontology<\/i>, 2014.<\/li>\n<li><i>Anisimov, V. N., et al.<\/i> Effect of Epithalon on biomarkers of aging, life span, and spontaneous carcinogenesis in experimental models. <i>Experimental Gerontology<\/i>, 2003.<\/li>\n<li><i>Khavinson, V. K., &amp; Bondarev, I. E.<\/i> Epithalon stimulates gene expression of telomerase reverse transcriptase in human fibroblasts. <i>Advances in Gerontology<\/i>, 2004.<\/li>\n<\/ul>\n<p><strong>Pr\u00e1vn\u00ed prohl\u00e1\u0161en\u00ed a podm\u00ednky n\u00e1kupu<\/strong><\/p>\n<p>Tento produkt je klasifikov\u00e1n a dod\u00e1v\u00e1n <strong>v\u00fdhradn\u011b pro laboratorn\u00ed, v\u011bdeck\u00e9 a in vitro v\u00fdzkumn\u00e9 \u00fa\u010dely (Research Use Only \u2013 RUO)<\/strong>. Slou\u010denina nen\u00ed l\u00e9\u010divem, l\u00e9kem, dopl\u0148kem stravy, kosmetick\u00fdm p\u0159\u00edpravkem ani l\u00e1tkou ur\u010denou pro hum\u00e1nn\u00ed \u010di veterin\u00e1rn\u00ed spot\u0159ebu, p\u0159\u00edmou aplikaci, injek\u010dn\u00ed pod\u00e1n\u00ed nebo diagnostick\u00e9 pou\u017eit\u00ed.<\/p>\n<p>Odesl\u00e1n\u00edm objedn\u00e1vky kupuj\u00edc\u00ed v\u00fdslovn\u011b potvrzuje, \u017ee <strong>dovr\u0161il v\u011bk minim\u00e1ln\u011b 18 let<\/strong>, disponuje pot\u0159ebnou odbornou zp\u016fsobilost\u00ed i technick\u00fdm vybaven\u00edm pro manipulaci s v\u00fdzkumn\u00fdmi materi\u00e1ly a je v pln\u00e9m rozsahu sezn\u00e1men s bezpe\u010dnostn\u00edmi protokoly nakl\u00e1d\u00e1n\u00ed s v\u00fdzkumn\u00fdmi l\u00e1tkami. Prod\u00e1vaj\u00edc\u00ed nenese \u017e\u00e1dnou odpov\u011bdnost za pou\u017eit\u00ed produktu v rozporu s t\u011bmito podm\u00ednkami.<\/p>\n","protected":false},"excerpt":{"rendered":"<ul>\n<li><strong>\u00da\u010del pou\u017eit\u00ed:<\/strong> Tento produkt je dod\u00e1v\u00e1n <strong>v\u00fdhradn\u011b pro laboratorn\u00ed, v\u011bdeck\u00e9 a v\u00fdzkumn\u00e9 \u00fa\u010dely (Research Use Only \/ in vitro)<\/strong>. Nejedn\u00e1 se o l\u00e9\u010divo, potravinu ani dopln\u011bk stravy. L\u00e1tka nen\u00ed ur\u010dena k p\u0159\u00edm\u00e9 spot\u0159eb\u011b, aplikaci ani terapeutick\u00e9mu pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/li>\n<li><strong>Forma a obsah:<\/strong> Produkt je dod\u00e1v\u00e1n ve form\u011b steriln\u00edho lyofilizovan\u00e9ho pr\u00e1\u0161ku v uzav\u0159en\u00e9 laboratorn\u00ed lahvi\u010dce (vialce). Neobsahuje rekonstitu\u010dn\u00ed roztok, pokud nen\u00ed v\u00fdslovn\u011b uvedeno jinak.<\/li>\n<li><strong>Doporu\u010den\u00e9 skladov\u00e1n\u00ed:<\/strong> Pro zachov\u00e1n\u00ed stability uchov\u00e1vejte neotev\u0159enou lahvi\u010dku v chladu, suchu a temnu p\u0159i teplot\u011b 2\u20138 \u00b0C (pro dlouhodob\u00e9 skladov\u00e1n\u00ed doporu\u010deno -20 \u00b0C).<\/li>\n<li><strong>Ilustra\u010dn\u00ed vyobrazen\u00ed:<\/strong> Obr\u00e1zek produktu slou\u017e\u00ed pouze k <strong>ilustra\u010dn\u00edm \u00fa\u010del\u016fm<\/strong>. Skute\u010dn\u00e9 proveden\u00ed lahvi\u010dky, barva t\u011bsn\u011bn\u00ed\/v\u00ed\u010dka (flip-off) \u010di design laboratorn\u00ed etikety se mohou li\u0161it v z\u00e1vislosti na v\u00fdrobn\u00ed \u0161ar\u017ei.<\/li>\n<\/ul>\n","protected":false},"featured_media":0,"template":"","meta":[],"product_brand":[],"product_cat":[58],"product_tag":[],"class_list":["post-1703","product","type-product","status-publish","product_cat-sostanze-liofilizzate","pa_obsah-10mg","pa_obsah-50mg","first","instock","purchasable","product-type-variable","has-default-attributes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Epithalon - Nextrabiochem.eu<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Epithalon - Nextrabiochem.eu\" \/>\n<meta property=\"og:description\" content=\"\u00da\u010del pou\u017eit\u00ed: Tento produkt je dod\u00e1v\u00e1n v\u00fdhradn\u011b pro laboratorn\u00ed, v\u011bdeck\u00e9 a v\u00fdzkumn\u00e9 \u00fa\u010dely (Research Use Only \/ in vitro). 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