Description

Vesugen – Lyophilized Peptide for In Vitro Research (20 mg) Synthetic short peptide bioregulator (tripeptide) composed of specific amino acids, supplied in the form of high-purity lyophilisate for in vitro research on the vascular endothelium, vascular biology, gene expression regulation in vessel walls, and cellular aging (senescence processes).

Overview and Mechanism of Action (In Vitro) Vesugen is a cytoprotective peptide sequence designed to modulate metabolic and proliferative processes in cells of the vascular system. In experimental angiology, gerontology, and cell biology, it serves as a reference substance for studying vascular homeostasis:

• Modulation of cell cycle and proliferation in endothelial cultures: Influences the expression of genes associated with vascular wall regeneration and proliferation regulation in primary human umbilical vein endothelial cell (HUVEC) cultures.
• Protection against oxidative stress and endothelial dysfunction: In vitro studies demonstrate the ability to modulate the activity of enzymes associated with the production of reactive oxygen species (ROS) and support cellular integrity under conditions of induced oxidative stress.
• Epigenetic regulation and gene expression: Similar to other short peptide bioregulators, its influence on chromatin interaction and the transcriptional activity of genes responsible for vascular elasticity and tone is investigated.
• Lyophilized format for maximum stability: The product is supplied as a stable lyophilized powder, ensuring long-term purity and stability prior to reconstitution and allowing precise preparation of working solutions for laboratory protocols.

Technical and Chemical Specification

• Classification: Vascular peptide bioregulator / Short synthetic tripeptide / Research peptide (RUO)
• Product format: Lyophilized powder in a glass vial
• Substance content: 20 mg of pure lyophilisate per vial
• Amino acid sequence: Lys-Glu-Asp (specific tripeptide sequence derived from vascular extracts)
• Form: Lyophilized powder / highly purified biomolecule intended for reconstitution under laboratory conditions
• Recommended reconstitution: For in vitro use, reconstitute in a sterile buffered solution (e.g., PBS) or sterile deionized water for laboratories according to the specific protocol.
• Storage conditions: Store lyophilized powder at –20 °C (short-term at 2–8 °C in a dark and dry place). Protect from moisture and freezing. After reconstitution, keep refrigerated and consume according to laboratory standards.

Professional Sources and Literature

• Khavinson, V. K., et al. Short peptides regulate gene expression, protein synthesis and cellular aging. Rejuvenation Research, 2013.
• Soloviev, V. N., et al. Peptide bioregulation of vascular endothelial cells in experimental models. Bulletin of Experimental Biology and Medicine, 2015.

Legal Disclaimer and Terms of Purchase This product is classified and supplied exclusively for laboratory, scientific, and in vitro research purposes (Research Use Only – RUO). The lyophilized peptide is not a medicinal product, drug, weight-loss preparation, dietary supplement, or substance intended for human or veterinary consumption, oral ingestion, injection, or diagnostic procedures. By submitting an order, the buyer explicitly confirms that they have reached the age of at least 18 years, possess adequate laboratory infrastructure and personnel equipment for safe handling of research chemicals, and are fully familiar with laboratory safety protocols. The seller assumes no liability for any improper or unapproved use.