Description

Vilon

Synthetic bioactive ultrashort dipeptide bioregulator (Lys-Glu / L-lysyl-L-glutamic acid) for in vitro research on epigenetic chromatin decondensation, T-lymphocyte proliferation and differentiation, cytokine expression modulation, and cellular tissue regeneration

Overview & Mechanism of Action (In Vitro)

Vilon is a synthetic ultrashort peptide bioregulator composed of two amino acids (Lys-Glu / L-lysyl-L-glutamic acid), developed through structural analysis of bioactive polypeptide extracts of the thymus. Belonging to the class of Khavinson peptide bioregulators, it is characterized by direct interaction with nuclear chromatin and epigenetic modulation of transcription without requiring persistent binding to conventional cell-surface membrane receptors. In molecular immunology, biogerontology, and tissue engineering, it serves as a primary reference standard for studying immune regulation and cellular senescence:

• Epigenetic Chromatin Decondensation: Direct interaction with DNA sequences and nuclear histones in lymphoid and somatic cells induces the relaxation of condensed heterochromatin, facilitating the transcriptional activation of repressed protective and differentiation genes.
• Stimulation of T-Lymphocyte Proliferation & Maturation: Promotes cellular division, upregulation of surface differentiation markers, and functional maturation of thymocytes and peripheral lymphocytes in primary cell cultures in vitro.
• Cytokine Network Balancing & Anti-Inflammatory Signaling: Regulates the gene transcription of pro- and anti-inflammatory mediators; optimizes interleukin-2 (IL-2) and interferon-gamma (IFN-γ) production while attenuating excessive expression of pro-inflammatory cytokines (TNF-α, IL-6).
• Tissue Repair & Senescence Attenuation: Enhances structural protein synthesis, increases cellular metabolic viability, and reduces the expression of senescence-associated markers in aging cell lines (e.g., dermal fibroblasts and epithelial models).

Technical & Chemical Specifications

• Classification: Research Peptide Bioregulator / Ultrashort Thymic Dipeptide (Khavinson Peptide)
• Amino Acid Sequence: H-Lys-Glu-OH (L-Lys-L-Glu / KE)
• Molecular Formula: C11H21N3O5
• Molecular Weight: ≈275.30 g/mol
• Form: Sterile lyophilized white crystalline powder (cake)
• Component Identification: Verified via Mass Spectrometry (MS), NMR spectroscopy, and analytical HPLC
• Recommended Reconstitution Solvent: Sterile deionized water, sterile bacteriostatic water, or sterile phosphate-buffered saline (PBS, pH 7.2–7.4)
• Storage Conditions: Store long-term at -20 °C in a dry, dark environment in a tightly sealed container. Following reconstitution, keep refrigerated at 2–8 °C in accordance with standard laboratory protocols.

Scientific References & Literature

• Khavinson, V. K., et al. Dipeptide Vilon enhances chromatin decondensation in human lymphoid cells. Bulletin of Experimental Biology and Medicine, 2003.
• Anisimov, V. N., et al. Effect of the synthetic dipeptide Vilon on biomarkers of aging, lifespan, and spontaneous tumor incidence in mice. Biogerontology, 2011.
• Khavinson, V. K., & Malinin, V. V. Geroprotective effect of synthetic peptide bioregulators: Molecular mechanisms and clinical perspectives. Advances in Gerontology, 2005.
• Kuznik, B. I., et al. Peptides of the immune system in the regulation of cellular homeostasis and epigenetics. Frontiers in Bioscience, 2018.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.