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Cardiogen 20mg

Cardiogen 20mg

59,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: CG20 Category:

10 in stock

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Description

Cardiogen

Synthetic bioactive tetrapeptide bioregulator (Ala-Glu-Asp-Arg) for in vitro research on cardiomyocyte differentiation, myocardial epigenetic gene regulation, cardiac fibrosis modulation, and cellular cardioprotection

Overview & Mechanism of Action (In Vitro)

Cardiogen is a synthetic ultra-short peptide (tetrapeptide) consisting of four amino acids with the sequence (Ala-Glu-Asp-Arg / AEDR), developed within the framework of short peptide bioregulators targeting myocardial tissue. It exhibits high cellular and nuclear membrane permeability, operating primarily through direct epigenetic modulation of chromatin dynamics and nuclear transcription rather than classical surface receptor activation. In molecular cardiology, cellular biogerontology, and regenerative tissue models, it serves as a primary reference standard for studying myocardial homeostasis and tissue remodeling:

  • Direct Epigenetic Interaction with Histones & DNA: Rapidly penetrates the nuclear envelope of cardiomyocytes to interact site-specifically with histone complexes (H1, H2B, H3, H4) and nucleotide motifs, enhancing the transcriptional accessibility of genes encoding essential myocardial structural and metabolic proteins.
  • Stimulation of Cytoskeletal & Contractile Protein Synthesis: Upregulates the expression of key structural proteins (actin, vimentin, and tubulin) in cardiomyocyte cultures, reinforcing structural scaffolding and functional contractile architecture in vitro.
  • Modulation of Cardiomyocyte Proliferation & Apoptosis Suppression: Promotes cellular viability and cell cycle progression (G1/S phase transition) in primary cardiomyocyte lines under hypoxic and ischemic challenge while attenuating pro-apoptotic signaling (such as p53 expression).
  • Fibroblast Proliferation Regulation & Anti-Fibrotic Profiling: Selectively regulates cardiac fibroblast hyper-proliferation and attenuates excessive extracellular matrix deposition (collagen types I and III), providing a robust model for investigating the mitigation of fibrotic tissue remodeling following ischemic injury.

Technical & Chemical Specifications

  • Classification: Research Tetrapeptide / Myocardial Peptide Bioregulator (Khavinson Analogue)
  • Amino Acid Sequence: Ala-Glu-Asp-Arg (AEDR / H-Ala-Glu-Asp-Arg-OH)
  • Form: Sterile lyophilized white powder (cake)
  • Component Identification: Verified via Mass Spectrometry (MS) and analytical HPLC
  • Recommended Reconstitution Solvent: Sterile bacteriostatic water or sterile phosphate-buffered saline (PBS)
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C in accordance with standard laboratory protocols.

Scientific References & Literature

  • Khavinson, V. K., et al. Peptide regulation of gene expression and protein synthesis in cardiomyocytes during aging and oxidative stress. Bulletin of Experimental Biology and Medicine, 2011.
  • Anisimov, V. N., & Khavinson, V. K. Peptide bioregulators: A new class of biological response modifiers and epigenetic modulators in myocardial biology. Biogerontology, 2010.
  • Khavinson, V. K., et al. Effect of short peptides on the proliferation and differentiation of cardiac cells in organotypic cultures. Cell and Tissue Biology, 2013.
  • Lezhava, T. A., et al. Epigenetic effects of the tetrapeptide Cardiogen (AEDR) on chromatin remodeling and structural protein transcription. Biomedical and Environmental Sciences, 2016.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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