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Ipamorelin Capsules

Ipamorelin Capsules

47,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The compound in a solid carrier is not intended for application, consumption, or any therapeutic use in humans or animals.
  • Form & Presentation: Contains precisely pre-weighed research material within an enclosed capsule carrier for convenient laboratory handling.
  • Recommended Storage: Store in the original sealed container in a cool, dry, and dark place at temperatures up to 20 °C. Protect from moisture and direct sunlight.
  • Illustrative Product Image: Product images are for illustrative purposes only. Capsule coloration, packaging format, or laboratory label design may vary depending on the production batch.
Product code: IP100 Category:

10 in stock

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Description

Ipamorelin – Research Capsules for Laboratory Purposes (100 mcg / capsule, 60 count)

Highly selective synthetic pentapeptide agonist of the ghrelin receptor (GHSR-1a) and growth hormone secretagogue in a solid analytical matrix for in vitro research on somatotropic pulsatile signaling, cell proliferation, myoblast differentiation, and receptor kinetics

Overview & Mechanism of Action (In Vitro)

Ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH2) is a third-generation synthetic pentapeptide belonging to the growth hormone secretagogue (GHS) family, characterized by its remarkable selectivity for the GHSR-1a receptor (ghrelin receptor). In cellular biology, molecular endocrinology, and biophysical research, it serves as a primary reference ligand for investigating pure somatotropic axis activation without non-specific off-target endocrine activation:

  • High Receptor Selectivity for GHSR-1a: Binds to the Gαq/11-coupled GHSR-1a receptor to activate phospholipase C (PLC), resulting in protein kinase C (PKC) phosphorylation and a transient increase in intracellular calcium (Ca2+), facilitating exocytosis of somatotropic storage granules in pituitary cell models.
  • Absence of Non-Specific Corticotropic Cross-Stimulation: Unlike earlier-generation analogs, it exhibits negligible in vitro cross-activation of ACTH, cortisol, or prolactin release pathways, allowing precise isolation of GH-specific signaling events.
  • Stimulation of Myoblast Proliferation & Maturation: Enhances downstream insulin-like growth factor 1 (IGF-1) gene expression in primary culture models, promoting Akt/mTOR pathway activation and myotube differentiation in vitro.
  • Modulation of Osteoblast Differentiation: Promotes alkaline phosphatase (ALP) expression and type I collagen synthesis in primary osteoblast lines, serving as a model for in vitro bone cell mineralization studies.

Technical & Chemical Specifications

  • Classification: Selective GHSR-1a Peptide Agonist in Solid Matrix / Reagent Analytical Capsules (RUO)
  • Amino Acid Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2
  • Molecular Formula: C38H49N9O5
  • Active Content: 100 mcg (0.1 mg) per capsule (±2%)
  • Packaging Unit: 60 research capsules in a laboratory container with integrated desiccant
  • Form: Solid reagent matrix / encapsulated standard
  • Component Identification: Verified via Analytical HPLC and Mass Spectrometry (MS)
  • Recommended Reconstitution Protocol: Capsule contents are intended for dissolution in sterile laboratory buffers (e.g., sterile PBS pH 7.2–7.4) or sterile deionized water to prepare calibrated working solutions for in vitro cell culture assays.
  • Storage Conditions: Store at 15–25 °C in a dry, dark environment in the tightly sealed original container with desiccant. For long-term archiving of analytical standards, storage at -20 °C is recommended.

Scientific References & Literature

  • Raun, K., et al. Ipamorelin, the first selective growth hormone secretagogue: In vitro pharmacology and receptor selectivity profile. European Journal of Endocrinology, 1998.
  • Jimenez-Reina, L., et al. In vitro effects of the growth hormone secretagogue ipamorelin on rat pituitary somatotroph cells. Histology and Histopathology, 2002.
  • Svensson, J., et al. The GH secretagogues ipamorelin and GHRP-6 stimulate bone growth and osteoblast differentiation in vitro. Journal of Endocrinology, 2000.
  • Smith, R. G., et al. Development of growth hormone secretagogues: Molecular mechanisms and in vitro cellular signaling. Endocrine Reviews, 2005.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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