Description

Noopept – Research Capsules for Laboratory Purposes (20 mg / capsule, 60 count)

Synthetic dipeptide analog of piracetam (N-phenylacetyl-L-prolylglycine ethyl ester / GVS-111) in a solid analytical matrix for in vitro research on neurotrophin expression (NGF and BDNF), glutamatergic and cholinergic receptor modulation, synaptic plasticity, and neuroprotective pathways

Overview & Mechanism of Action (In Vitro)

Noopept (N-phenylacetyl-L-prolylglycine ethyl ester / GVS-111) is a synthetic dipeptidomimetic compound structurally based on the endogenous neuropeptide cycloprolylglycine. In cellular neurobiology, molecular neuroscience, and biochemical research, it serves as a primary reference standard for mapping signaling cascades associated with neurotrophic factor synthesis, oxidative stress mitigation, and ligand-gated ion channel modulation:

• Induction of Neurotrophin Synthesis (NGF & BDNF) In Vitro: Upregulates mRNA transcription and protein levels of Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) in primary hippocampal and cortical neuronal cultures.
• Positive Allosteric Modulation of AMPA & NMDA Receptors: Enhances postsynaptic ionotropic glutamate receptor sensitivity to endogenous ligands, facilitating long-term potentiation (LTP) and supporting synaptic plasticity mechanisms in vitro.
• Sensitization of Cholinergic Neurotransmission: Acts as a sensitizer of central cholinergic receptors, enhancing cellular responsiveness to acetylcholine and promoting intracellular calcium dynamics.
• Cytoprotection & Reduction of Oxidative Toxicity: Suppresses reactive oxygen species (ROS) accumulation, attenuates glutamate-induced excitotoxicity, and downregulates apoptotic cascades in neuronal models exposed to β-amyloid toxicity.

Technical & Chemical Specifications

• Classification: Dipeptide Nootropic Ligand / Research Standard in Solid Matrix / Reagent Analytical Capsules (RUO)
• Chemical Name: Ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate
• Molecular Formula: C17H22N2O4
• Molecular Weight: 318.37 g/mol
• Active Content: 20 mg per capsule (±2%)
• Packaging Unit: 60 research capsules in a laboratory container with integrated desiccant
• Form: Solid reagent matrix / encapsulated standard
• Component Identification: Verified via Analytical HPLC and Mass Spectrometry (MS / NMR)
• Recommended Reconstitution Protocol: Capsule contents are intended for dissolution in suitable laboratory solvents (e.g., DMSO for concentrated stock solutions or sterile laboratory buffers / sterile deionized water) to prepare calibrated working solutions for in vitro cellular assays.
• Storage Conditions: Store at 15–25 °C in a dry, dark environment in the tightly sealed original container with desiccant. For long-term archiving of analytical standards, storage at -20 °C is recommended.

Scientific References & Literature

• Ostrovskaya, R. U., et al. The original novel nootropic and neuroprotective agent Noopept. Experimental and Clinical Pharmacology, 2002.
• Radionova, K. S., et al. Effects of Noopept on the expression of NGF and BDNF in the hippocampus and cerebral cortex in vitro and in cellular assays. Bulletin of Experimental Biology and Medicine, 2008.
• Jia, X., et al. Neuroprotective and anti-apoptotic actions of Noopept in cellular models of amyloid-beta-induced neuronal damage. Journal of Molecular Neuroscience, 2011.
• Vakhitova, Y. V., et al. Molecular mechanisms of action of the dipeptide nootropic agent Noopept on receptor-mediated signaling pathways. Acta Naturae, 2016.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.