Description

Adipotide

Synthetic pro-apoptotic peptidomimetic conjugate (FTPP / prohibitin-targeting peptide) for in vitro research on targeted adipose vascular ablation, mitochondrial apoptosis, and metabolic tissue remodeling

Overview & Mechanism of Action (In Vitro)

Adipotide (also designated as FTPP or CKGGRAKDC-GG-(KLAKLAK)2​​) is a synthetic chimeric peptidomimetic composed of two distinct functional domains: an endothelial homing sequence targeting white adipose tissue vasculature and a membrane-disrupting pro-apoptotic sequence. In molecular biology, experimental oncology, and metabolic research, it serves as a primary model for investigating targeted anti-angiogenic vascular ablation:

• Targeted Binding to Cell-Surface Prohibitin: The homing domain (Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys) selectively binds to prohibitin expressed on the surface of endothelial cells lining white adipose tissue (WAT) blood vessels.
• Induction of Mitochondrial Apoptosis: Following cellular internalization, the pro-apoptotic D​Lys-Leu-Ala-Lys-Leu-Ala-Lys2 amphipathic domain disrupts inner mitochondrial membrane integrity, triggering cytochrome c release, caspase-9 and caspase-3 cascade activation, and programmed cell death.
• Ablation and Remodeling of Adipose Microvasculature: Modeling targeted vascular occlusion, endothelial cell death, and subsequent starvation/resorption of adipocyte clusters in endothelial-adipocyte co-culture systems in vitro.
• Metabolic Selectivity over Brown Adipose Tissue: Analysis of selective homing properties, demonstrating minimal affinity for brown adipose tissue (BAT) vasculature and essential systemic vascular beds.

Technical & Chemical Specifications

• Classification: Research Peptide / Targeted Vascular Pro-Apoptotic Conjugate
• Amino Acid Sequence: H-Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys-Gly-Gly-D​​(Lys-Leu-Ala-Lys-Leu-Ala-Lys)2​​-NH2 (with intramacromolecular disulfide bond in homing domain)
• Form: Sterile lyophilized white powder (cake)
• Component Identification: Verified via Mass Spectrometry (MS) and analytical HPLC
• Recommended Reconstitution Solvent: Sterile bacteriostatic water or sterile phosphate-buffered saline (PBS)
• Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C in accordance with standard laboratory protocols.

Scientific References & Literature

• Kolonin, M. G., et al. Reversal of obesity by targeted ablation of adipose tissue vasculature. Nature Medicine, 2004.
• Barnhart, K. F., et al. A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in nonhuman primates. Science Translational Medicine, 2011.
• Ellerby, H. M., et al. Anti-cancer activity of targeted pro-apoptotic peptides. Nature Medicine, 1999.
• Kim, D. H., et al. Prohibitin is a cell-surface receptor for targeted delivery to white fat vasculature. Cell, 2006.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.