Description

AOD-9604 – Research Capsules for Laboratory Purposes (100 mcg / capsule, 60 count)

Synthetic modified C-terminal peptide fragment of human growth hormone (hGH 177–191) in a solid analytical matrix for in vitro research on lipolytic pathway activation, lipogenesis inhibition in adipocyte cultures, cartilage metabolism, and cell differentiation

Overview & Mechanism of Action (In Vitro)

AOD-9604 (Advanced Obesity Drug-9604) is a synthetic 16-amino acid peptide analog corresponding to the lipolytic C-terminal domain of native human growth hormone (hGH 177–191), stabilized by an N-terminal tyrosine addition and an intramolecular disulfide bridge. In cellular biology, experimental endocrinology, and cellular metabolism research, it serves as a primary standard for investigating isolated lipid metabolic pathways without altering glycemic parameters or stimulating systemic IGF-1 production:

• Stimulation of Lipolytic Flux in Adipocyte Cultures: Upregulates the expression and catalytic activity of hormone-sensitive lipase (HSL), promoting the release of free fatty acids and glycerol in primary and immortalized adipocyte models in vitro.
• Inhibition of Lipogenesis & Intracellular Lipid Storage: Suppresses key lipogenic enzymes (notably fatty acid synthase, FAS) and attenuates lipid droplet accumulation during the differentiation of preadipocytes into mature adipocytes.
• Absence of hGH/IGF-1 Mitogenic Signaling: Does not bind to the classical human growth hormone receptor (GHR), avoiding STAT5 transcription factor activation and IGF-1 gene induction, which enables the selective study of metabolic pathways.
• Modulation of Chondrogenesis & Extracellular Matrix Deposition: Promotes extracellular matrix synthesis, specifically type II collagen and proteoglycans, in experimental in vitro chondrocyte cultures.

Technical & Chemical Specifications

• Classification: Synthetic hGH (177–191) Peptide Analog in Solid Matrix / Reagent Analytical Capsules (RUO)
• Amino Acid Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (Disulfide bridge Cys7–Cys14)
• Molecular Formula: C78H123N23O23S2
• Active Content: 100 mcg (0.1 mg) per capsule (±2%)
• Packaging Unit: 60 research capsules in a laboratory container with integrated desiccant
• Form: Solid reagent matrix / encapsulated standard
• Component Identification: Verified via Analytical HPLC and Mass Spectrometry (MS)
• Recommended Reconstitution Protocol: Capsule contents are intended for dissolution in sterile laboratory buffers (e.g., sterile PBS pH 7.2–7.4) or sterile water to prepare calibrated working solutions for in vitro cellular assays.
• Storage Conditions: Store at 15–25 °C in a dry, dark environment in the tightly sealed original container with desiccant. For long-term archiving of analytical standards, storage at -20 °C is recommended.

Scientific References & Literature

• Ng, F. M., et al. Development of a metabolic peptide (AOD9604) derived from the C-terminal domain of human growth hormone. Journal of Molecular Endocrinology, 2000.
• Heffernan, M., et al. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism and in vitro adipocyte signaling. Endocrinology, 2001.
• Stier, H., et al. Safety and regulatory evaluation of peptide AOD9604 in laboratory metabolic characterizations. Regulatory Toxicology and Pharmacology, 2013.
• Kwon, D. R., et al. Effect of intra-articular injection of AOD9604 with hyaluronic acid on cartilage degradation in vitro and in animal models. Annals of Clinical and Laboratory Science, 2015.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.