Description

Epithalon – Pre-filled Laboratory Cartridge for In Vitro Research (20 mg / 3 ml)

Synthetic biomimetic epithalamin tetrapeptide (Ala-Glu-Asp-Gly) in a pre-formulated stabilized buffered solution for in vitro research on telomerase (hTERT) activation, telomere elongation, epigenetic chromatin remodeling, and cellular senescence

Overview & Mechanism of Action (In Vitro)

Epithalon (also referred to as Epitalon or tetrapeptide AGAG) is a synthetic bioactive peptide modeled after the endogenous pineal regulatory peptide complex. In molecular gerontology, cellular bioenergetics, and epigenetic research, it serves as a primary reference standard for investigating cellular aging pathways, genomic stability, and transcription factor modulation across cultured cell models:

• Induction of Telomerase Expression & Catalytic Activity (hTERT): Stimulates the mRNA expression of the catalytic subunit of human telomerase reverse transcriptase (hTERT) in somatic cell cultures in vitro, enabling detailed analysis of telomere length maintenance and cellular lifespan dynamics.
• Epigenetic Regulation & Chromatin Remodeling: Interacts directly with histone complexes and specific DNA regulatory domains, modulating chromatin accessibility, attenuating aberrant gene hypermethylation, and maintaining the expression of structural integrity genes.
• Reduction of Cellular Senescence Phenotypes: Downregulates senescence-associated -galactosidase (SA–gal) activity and suppresses the secretion of pro-inflammatory factors comprising the senescence-associated secretory phenotype (SASP) in vitro.
• Pre-formulated Format for Precise Laboratory Dispensing: The stabilized liquid formulation within a 3 ml cartridge eliminates manual dilution variability, ensuring exceptional homogeneity and concentration consistency for automated and semi-automated micro-dispensing systems.

Technical & Chemical Specifications

• Classification: Biomimetic Tetrapeptide / Telomerase Activator / Research Peptide Solution (RUO)
• Product Format: Pre-filled calibrated laboratory cartridge (3 ml volume)
• Compound Strength: 20 mg / 3 ml (approx. 6.67 mg/ml concentration)
• Amino Acid Sequence: Ala-Glu-Asp-Gly (H-Ala-Glu-Asp-Gly-OH)
• Molecular Formula:
• Molecular Weight:
• Form: Sterile stabilized solution / Ready-to-Use (RTU)
• Solution Matrix: Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)
• Compatibility: Compatible with standard laboratory dispensing pens and micro-dispensers for 3 ml cartridges (dispensing pen/injector is not included in the package)
• Storage Conditions: Store at 2–8 °C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.

Scientific References & Literature

• Khavinson, V. K., et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells in vitro. Bulletin of Experimental Biology and Medicine, 2003.
• Anisimov, V. N., et al. Synthetic peptide Epithalon modulates cellular senescence, oxidative stress markers, and DNA damage responses in vitro. Biogerontology, 2010.
• Khavinson, V. K., et al. Peptide regulation of gene expression and protein synthesis in cell cultures during aging. Current Pharmaceutical Design, 2014.
• Siborov, V. A., et al. Epigenetic effects of pineal tetrapeptides on chromatin structure and transcriptional activity in human fibroblast models. Cellular and Molecular Biology Letters, 2019.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). The stabilized peptide solution and mechanical cartridge are not drugs, medicines, weight-loss agents, dietary supplements, or cosmetic products, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.