Description

Epithalon – Research Capsules for Laboratory Purposes (3 mg / capsule, 60 count)

Synthetic biomimetic pineal tetrapeptide (Ala-Glu-Asp-Gly / AEDG) in a solid analytical matrix for in vitro research on telomerase reverse transcriptase (hTERT) expression, telomere length dynamics, chromosomal stability, heterochromatin remodeling, and cellular senescence

Overview & Mechanism of Action (In Vitro)

Epithalon (Epitalon / Ala-Glu-Asp-Gly / epithalamin-derived tetrapeptide) is a synthetic short bioactive peptide modeled after the native pineal bioregulatory fraction. In molecular gerontology, cellular cytogenetics, and aging research, it represents a primary reference standard for studying mechanisms that bypass the Hayflick limit in somatic cell lines, reactivate the catalytic telomerase complex, and modulate gene accessibility via heterochromatin relaxation:

• Induction of Telomerase (hTERT) Expression & Catalytic Activity: Stimulates the transcription of human telomerase reverse transcriptase (hTERT), restoring telomerase enzymatic activity and facilitating telomere maintenance or elongation in primary human somatic fibroblast cultures in vitro.
• Overcoming Replicative Senescence (Hayflick Limit): Enables somatic cells to undergo additional replication cycles while maintaining structural chromosomal integrity and reducing spontaneous aneuploidy across extended cellular passages.
• Epigenetic Remodeling & Heterochromatin Decondensation: Interacts directly with histone proteins and core chromatin structures, leading to the decondensation of facultative heterochromatin and restoring the transcriptional accessibility of cytoprotective genes.
• Antioxidant Enzyme Upregulation & Cytoprotection: Enhances the mRNA expression and enzymatic activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx), protecting subcellular structures from reactive oxygen species (ROS) and ultraviolet radiation.

Technical & Chemical Specifications

• Classification: Synthetic Biomimetic Tetrapeptide / Pineal Bioregulatory Standard in Solid Matrix (RUO)
• Amino Acid Sequence: Ala-Glu-Asp-Gly (H-Ala-Glu-Asp-Gly-OH)
• Chemical Name: L-alanyl-L-α-glutamyl-L-α-aspartylglycine
• Molecular Formula: C14H22N4O9
• Molecular Weight: 390.35 g/mol
• Active Content: 3 mg per capsule (±2%)
• Packaging Unit: 60 research capsules in a laboratory container with integrated desiccant
• Form: Solid reagent matrix / encapsulated standard
• Component Identification: Verified via Analytical HPLC and Mass Spectrometry (MS)
• Recommended Reconstitution Protocol: Capsule contents are intended for dissolution in sterile laboratory buffers (e.g., sterile PBS pH 7.2–7.4) or sterile deionized water to prepare calibrated working solutions for in vitro cell culture assays.
• Storage Conditions: Store at 15–25 °C in a dry, dark environment in the tightly sealed original container with desiccant. For long-term archiving of analytical standards, storage at -20 °C is recommended.

Scientific References & Literature

• Khavinson, V. K., et al. Peptide Epitalon activates chromatin at the old age: In vitro epigenetic and cytogenetic analysis. Bulletin of Experimental Biology and Medicine, 2002.
• Khavinson, V. K., et al. Epithalon peptide induces telomerase activity and extends telomeres in human somatic cell cultures. Bulletin of Experimental Biology and Medicine, 2003.
• Anisimov, V. N., et al. Synthetic pineal tetrapeptide Epithalon: In vitro cellular dynamics and modulation of lifespan signaling. Neuroendocrinology Letters, 2001.
• Kozina, L. S., et al. Effect of peptide Ala-Glu-Asp-Gly on the expression of antioxidant defense genes and protection against reactive oxygen species in vitro. Advances in Gerontology, 2011.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.