Description

Kisspeptin-10 – Pre-filled Laboratory Cartridge for In Vitro Research (10 mg / 3 ml)

Synthetic bioactive decapeptide and high-affinity agonist of the metastin/KISS1 receptor (KISS1R / GPR54) in a pre-formulated stabilized buffered solution for in vitro research on  signaling cascades, intracellular  mobilization, GnRH secretion dynamics, and gonadotropic axis regulation

Overview & Mechanism of Action (In Vitro)

Kisspeptin-10 is a synthetic decapeptide representing the core biologically active C-terminal sequence of endogenous metastin (the product of the KISS1 gene). In cellular biology, molecular endocrinology, and reproductive sciences, it serves as a primary reference standard for investigating upstream hypothalamic-pituitary-gonadal (HPG) axis regulation and KISS1R receptor pharmacology:

• Selective KISS1R (GPR54) Receptor Activation: Binds with nanomolar affinity to the -coupled KISS1R receptor, activating phospholipase C (PLC), stimulating inositol trisphosphate () and diacylglycerol (DAG) production, and inducing robust intracellular calcium () mobilization in neuronal cell lines.
• Direct Stimulation of GnRH Neuronal Depolarization: Triggers membrane depolarization and pulsatile exocytosis of gonadotropin-releasing hormone (GnRH) in primary hypothalamic cell cultures and GT1-7 neuronal models.
• Regulation of Downstream Gonadotropin Expression: Upregulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) subunit transcription in pituitary cell cultures via MAPK/ERK and p38 signaling networks in vitro.
• Modulation of Cell Motility & Anti-Metastatic Signaling: Regulates actin cytoskeletal reorganization and suppresses cell migration and extracellular matrix invasion in model cancer cell lines in vitro.
• Pre-formulated Format for Precise Laboratory Dispensing: The stabilized liquid matrix within a 3 ml cartridge eliminates manual reconstitution steps, ensuring exceptional homogeneity and concentration consistency for automated micro-dispensing systems.

Technical & Chemical Specifications

• Classification: KISS1R (GPR54) Agonist / Neuroendocrine Gonadotropic Modulator / Research Solution (RUO)
• Product Format: Pre-filled calibrated laboratory cartridge (3 ml volume)
• Compound Strength: 10 mg / 3 ml (approx. 3.33 mg/ml concentration)
• Amino Acid Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-
• Chemical Name: Kisspeptin-10 (metastin 45-54 amide)
• Molecular Formula:
• Molecular Weight:
• Form: Sterile stabilized clear solution / Ready-to-Use (RTU)
• Solution Matrix: Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)
• Compatibility: Compatible with standard laboratory dispensing pens and micro-dispensers for 3 ml cartridges (dispensing pen/injector is not included in the package)
• Storage Conditions: Store at 2–8 °C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.

Scientific References & Literature

• Kotani, M., et al. The metastasis suppressor gene KISS-1 encodes kisspeptins, the natural ligands of the orphan G-protein-coupled receptor GPR54: In vitro pharmacology and signaling. Journal of Biological Chemistry, 2001.
• Messager, S., et al. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54 in hypothalamic cell models. Proceedings of the National Academy of Sciences, 2005.
• Castellano, J. M., et al. Mechanisms of kisspeptin-10 activation of the gonadotropic axis: In vitro characterization of downstream LH/FSH secretion. Endocrinology, 2006.
• Castaño, J. P., et al. Intracellular signaling pathways mediating kisspeptin stimulation of pituitary and hypothalamic cells in vitro. Frontiers in Endocrinology, 2014.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). The stabilized peptide solution and mechanical cartridge are not drugs, medicines, fertility therapies, testosterone boosters, dietary supplements, or medical devices, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.