Description

KLOW

Synthetic multi-peptide research complex (BPC-157 + TB-500 + KPV + GHK-Cu) for in vitro research on anti-inflammatory modulation, cell migration, angiogenesis, and extracellular matrix remodeling

Overview & Mechanism of Action (In Vitro)

KLOW is an advanced multi-component laboratory blend combining four complementary research peptides: the pentadecapeptide BPC-157, the thymosin  fragment (TB-500), the anti-inflammatory tripeptide KPV (-MSH 11–13), and the copper tripeptide chelate (GHK-Cu). In molecular and cellular biology, it serves as an integrative model for investigating the simultaneous attenuation of inflammatory signaling and structural tissue remodeling:

• NF-B Inhibition & Anti-Inflammatory Pathways (KPV): Suppression of NF-B nuclear translocation, reducing the expression of pro-inflammatory cytokines (TNF-, IL-1$\beta$, IL-6) and modulating immune signaling cascades via melanocortin receptor interactions.
• Cellular Motility & Cytoskeletal Dynamics (TB-500): Sequestration of monomeric G-actin and regulation of actin filament assembly, driving directed cell migration in endothelial cells, keratinocytes, and fibroblasts.
• Angiogenesis & Endothelial Homeostasis (BPC-157): Activation of VEGFR2 receptor signaling cascades, up-regulation of eNOS expression, and structural stabilization of cell-to-cell junctions under cellular stress conditions.
• Extracellular Matrix Synthesis & Gene Expression (GHK-Cu): Stimulation of type I and III collagen, elastin, and glycosaminoglycan (GAG) production in dermal fibroblasts, alongside the modulation of matrix metalloproteinases (MMPs) and TIMP inhibitors.

This four-part formulation enables in vitro assessment of the crosstalk between inflammatory pathway suppression and active tissue matrix renewal within a single assay system.

Technical & Chemical Specifications

• Classification: Multi-Peptide Research Complex (4 components)
• Blend Composition: BPC-157 + TB-500 + KPV + GHK-Cu
• Form: Sterile lyophilized blue powder (cake)
• Component Identification: Verified via Mass Spectrometry (MS) and analytical HPLC
• Recommended Reconstitution Solvent: Sterile bacteriostatic water or sterile deionized laboratory water (avoid phosphate buffers due to the presence of GHK-Cu and the risk of insoluble copper phosphate precipitation)
• Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C and utilize within standard experimental protocol timelines.

Scientific References & Literature

• Luger, T. A., et al. The alpha-MSH-derived tripeptide KPV: Anti-inflammatory mechanisms and cellular targets. Annals of the New York Academy of Sciences, 2003.
• Sikiric, P., et al. Stable gastric pentadecapeptide BPC 157: In vitro and in vivo mechanisms in cellular protection and angiogenesis. Current Pharmaceutical Design, 2018.
• Goldstein, A. L., et al. Thymosin beta 4: Actin-sequestering protein and its multifaceted roles in cellular motility and tissue repair. Annals of the New York Academy of Sciences, 2007.
• Pickart, L., et al. Regenerative and protective actions of the GHK-Cu peptide in light of the new gene data. International Journal of Molecular Sciences, 2018.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.