Description

MOTS-c – Pre-filled Laboratory Cartridge for In Vitro Research (25 mg / 3 ml)

Mitochondrially encoded 16-amino acid bioactive peptide (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) in a pre-formulated stabilized buffered solution for in vitro research on AMPK pathway activation, folate-methionine cycle regulation, GLUT4 translocation, and mitochondrial metabolic plasticity

Overview & Mechanism of Action (In Vitro)

MOTS-c is a unique 16-amino acid peptide encoded by mitochondrial DNA (within the 12S rRNA locus) that acts as an endocrine mitochondrial signaling factor (mitokine). In cell biology, molecular metabolism, and cellular senescence research, it serves as a primary reference standard for investigating retrograde mitochondrial-to-nuclear communication and cellular bioenergetics:

• Direct Activation of the AMPK Signaling Cascade: Enhances AMP-activated protein kinase () phosphorylation across cellular models by promoting the accumulation of AICAR (an intermediate of de novo purine synthesis), mimicking states of cellular energy depletion in vitro.
• Inhibition of the Folate-Methionine Cycle & Purine Metabolism: Modulates one-carbon folate metabolism via targeted inhibition of de novo purine biosynthesis enzymes, prompting a metabolic switch toward lipid oxidation and cellular homeostasis.
• Support of GLUT4 Translocation & Glucose Utilization: In primary myoblast and skeletal muscle cell cultures, it stimulates the translocation of glucose transporter 4 (GLUT4) to the cell surface membrane independently of classical insulin cascades.
• Enhancement of Mitochondrial Biogenesis & Respiration: Upregulates PGC-1$\alpha$ expression and nuclear-encoded mitochondrial respiratory factors, increasing oxidative phosphorylation capacity and suppressing reactive oxygen species (ROS) accumulation under metabolic stress in vitro.
• Pre-formulated Format for Precise Laboratory Dispensing: The stabilized liquid matrix within a 3 ml cartridge eliminates manual reconstitution steps, ensuring exceptional homogeneity and concentration consistency for automated micro-dispensing systems.

Technical & Chemical Specifications

• Classification: Mitochondrial-Derived Peptide (MDP) / Metabolic Homeostasis Regulator / Research Solution (RUO)
• Product Format: Pre-filled calibrated laboratory cartridge (3 ml volume)
• Compound Strength: 25 mg / 3 ml (approx. 8.33 mg/ml concentration)
• Amino Acid Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• Chemical Name: Mitochondrial Open Reading Frame of the 12S rRNA Type-c
• Molecular Formula:
• Molecular Weight:
• Form: Sterile stabilized clear solution / Ready-to-Use (RTU)
• Solution Matrix: Sterile buffered isotonic solution for laboratory use (pH-optimized, requires no reconstitution or dilution)
• Compatibility: Compatible with standard laboratory dispensing pens and micro-dispensers for 3 ml cartridges (dispensing pen/injector is not included in the package)
• Storage Conditions: Store at 2–8 °C in a dark, refrigerated environment. Do not freeze. Maintain standard laboratory cold-chain protocols to preserve compound stability.

Scientific References & Literature

• Lee, C., et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces diet-induced insulin resistance in cellular models. Cell Metabolism, 2015.
• Kim, K. H., et al. MOTS-c, an AMPK-activating mitochondrial-derived peptide, regulates cellular metabolism and aging processes in vitro. Experimental & Molecular Medicine, 2018.
• Reynolds, J. C., et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of cellular physical performance and bioenergetics. Nature Communications, 2021.
• Kumagai, H., et al. Mitochondrial-derived peptides: Novel regulators of metabolism and retrograde signaling pathways in cell models. Antioxidants & Redox Signaling, 2020.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). The stabilized peptide solution and mechanical cartridge are not drugs, medicines, performance-enhancing agents, endurance supplements, dietary supplements, or medical devices, and are not intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory infrastructure to safely handle research substances, and are fully conversant with all relevant laboratory safety protocols. The seller assumes no liability for any use contrary to these terms.