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Sermorelin 5mg

Sermorelin 5mg

34,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: SM05 Category:

10 in stock

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Description

Sermorelin

Synthetic 29-amino acid functional N-terminal fragment of native GHRH (1–29) for in vitro research on growth hormone-releasing hormone receptor (GHRH-R) activation, somatotroph signaling, and pituitary GH secretion

Overview & Mechanism of Action (In Vitro)

Sermorelin (also designated as GRF 1–29) is a synthetic peptide consisting of 29 amino acids terminated with a C-terminal amide, with the sequence (Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2). It represents the shortest fully functional truncated sequence of the endogenous 44-amino acid human growth hormone-releasing factor (GHRH). In molecular endocrinology and neurobiological research, it serves as a primary model for investigating pituitary stimulation and physiological regulation of the somatotropic axis:

  • Selective Activation of the GHRH-R Receptor: Specific binding to G-protein-coupled receptors (Gαs) localized on pituitary somatotrophic cell membranes.
  • Activation of the cAMP / PKA Cascade & Calcium Influx: Adenylate cyclase stimulation leading to increased intracellular cyclic adenosine monophosphate (cAMP) levels, protein kinase A (PKA) activation, and opening of L-type voltage-gated calcium channels, triggering the exocytosis of growth hormone (GH) storage granules.
  • Preservation of Negative Feedback Dynamics (Somatostatin Axis): Evaluation of physiological pulsatile GH secretory dynamics in cellular models under native somatostatin-mediated counter-regulation, preventing unconstrained hypersecretion in laboratory models.
  • Stimulation of GH Gene Transcription & De Novo Synthesis: Upregulation of tissue-specific transcription factors (such as Pit-1) responsible for GH mRNA transcription and continuous peptide synthesis in somatotrophic cultures.

Technical & Chemical Specifications

  • Classification: Research Peptide / Selective GHRH (1–29) Amide Analogue
  • Amino Acid Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
  • Form: Sterile lyophilized white powder (cake)
  • Component Identification: Verified via Mass Spectrometry (MS) and analytical HPLC
  • Recommended Reconstitution Solvent: Sterile bacteriostatic water or sterile phosphate-buffered saline (PBS)
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C in accordance with standard laboratory protocols.

Scientific References & Literature

  • Gelato, M. C., et al. Effects of growth hormone-releasing factor (1–29) amide on growth hormone release in vitro and in experimental models. Journal of Clinical Endocrinology & Metabolism, 1985.
  • Mayo, K. E., et al. The growth hormone-releasing hormone receptor: Signal transduction and regulation of gene expression in somatotrophs. Recent Progress in Hormone Research, 1995.
  • Vance, M. L., et al. Growth-hormone-releasing hormone: In vitro characterization and physiological regulatory pathways. Endocrine Reviews, 1986.
  • Prakash, A., & Goa, K. L. Sermorelin: A review of its biological characteristics and diagnostic utility in growth hormone axis assessment. BioDrugs, 1999.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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