Description

TB-500 – Research Capsules for Laboratory Purposes (500 mcg / capsule, 60 count)

Synthetic bioactive peptide fragment of Thymosin Beta-4 (LKKTETQ / Ac-SDKP derived sequence) in a solid analytical matrix for in vitro research on G-actin sequestration, cell migration, cytoskeletal remodeling, angiogenesis, and anti-inflammatory signaling pathways

Overview & Mechanism of Action (In Vitro)

TB-500 is a synthetic peptide fragment corresponding to the primary functional domain of the native Thymosin Beta-4 (Tβ4) protein. In cellular biology, tissue engineering, and molecular physiology, it serves as a standardized research model for studying cytoskeletal dynamics, intercellular communication, and cellular repair processes. Formulated within a solid reagent matrix, it provides a stable presentation protected against ambient humidity, allowing precise aliquot dispensing without the need for immediate deep-freezing of reconstitution solutions:

• Regulation & Sequestration of Monomeric G-Actin: Functions as a primary intracellular G-actin sequestering peptide. It maintains the dynamic equilibrium between monomeric (G-actin) and polymerized filamentous actin (F-actin), essential for cytoskeletal plasticity and cellular motility.
• Stimulation of Cell Migration & In Vitro Tissue Remodeling: Accelerates the directional migration of endothelial cells, keratinocytes, and myoblasts in laboratory scratch wound assays.
• Angiogenesis & Capillary Tube Formation in Cell Cultures: Promotes endothelial cell tube organization and upregulates vascular endothelial growth factor (VEGF) signaling in primary endothelial lines.
• Modulation of Inflammatory Cascades & Oxidative Stress: Inhibits nuclear translocation of NF-κB and downregulates pro-inflammatory cytokines (TNF-α, IL-1$beta$, IL-6) in macrophage and fibroblast culture models.

Technical & Chemical Specifications

• Classification: Research Peptide in Solid Matrix / Reagent Analytical Capsules (RUO)
• Active Content: 500 mcg (0.5 mg) per capsule (±2%)
• Packaging Unit: 60 research capsules in a laboratory container with integrated desiccant
• Form: Solid reagent matrix / encapsulated powder standard
• Component Identification: Verified via Analytical HPLC and Mass Spectrometry (MS)
• Recommended Reconstitution Protocol: Capsule contents are intended for dissolution in sterile laboratory buffers (e.g., sterile PBS pH 7.2–7.4) or sterile water to prepare calibrated working solutions for in vitro cell assays.
• Storage Conditions: Store at 15–25 °C in a dry, dark environment in the tightly sealed original container with desiccant. For long-term archiving of analytical standards, storage at -20 °C is recommended.

Scientific References & Literature

• Goldstein, A. L., et al. Thymosin beta4: Actin-sequestering protein and its multifunctional role in tissue repair and regeneration. Expert Opinion on Biological Therapy, 2012.
• Philp, D., et al. Thymosin beta4 promotes cell migration, angiogenesis, and accelerates dermal wound healing in vitro and in vivo. Journal of Cellular Biochemistry, 2004.
• Bock-Marquette, I., et al. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell survival and vascular progenitor differentiation. Nature, 2004.
• Sosne, G., et al. Thymosin beta 4 suppresses inflammatory signaling pathways and reduces oxidative stress in corneal and epithelial cell models. Experimental Eye Research, 2007.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.