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Semax

Semax

From 18,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: XA5 Category:
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Description

Semax

Synthetic heptapeptide for in vitro research on neurotrophic and neuromodulatory signaling pathways

Overview & Mechanism of Action (In Vitro)

Semax is a synthetic regulatory peptide composed of 7 amino acids (sequence Met-Glu-His-Phe-Pro-Gly-Pro), derived from the structural fragment ACTH(4–10) with a C-terminal stabilizing Pro-Gly-Pro tripeptide sequence. In biochemical and neurobiological research, it is utilized to model cellular pathways devoid of hormonal activity associated with full-length ACTH:

  • Modulation of Neurotrophic Factors: Evaluating regulatory effects on BDNF (Brain-Derived Neurotrophic Factor) and its high-affinity receptor TrkB expression in hippocampal cell lines.
  • Neurochemical Signaling: Investigating interactions with dopaminergic and serotonergic signaling cascades and analyzing the enzymatic degradation profiles of endogenous regulatory peptides.
  • Cellular Protection & Antioxidant Pathways: Analysis of gene expression profiles involved in immune response pathways and investigation of interactions with copper ions (Cu2+) in amyloid aggregation models.

Due to the C-terminal Pro-Gly-Pro motif, the compound exhibits marked enzymatic resistance against tissue peptidases in experimental setups compared to native ACTH(4–10).

Technical & Chemical Specifications

  • Classification: Research Peptide / ACTH(4–10) Fragment Analog
  • Amino Acid Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
  • Form: Sterile lyophilized white powder (cake)
  • Molecular Weight Identification: Confirmed via Mass Spectrometry (MS)
  • Recommended Reconstitution Solvent: Sterile bacteriostatic water or phosphate-buffered saline (PBS)
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C and utilize within standard experimental protocol timelines.

Scientific References & Literature

  • Ashmarin, I. P., et al. Semax, an ACTH(4-10) analogue with nootropic and neuroprotective properties: Mechanisms of biological action. Neurochemical Journal, 2007.
  • Dolotov, O. V., et al. Semax, an analogue of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Research, 2006.
  • Medvedeva, E. V., et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia. BMC Genomics, 2014.
  • Grigorian, S. S., et al. Structural and functional aspects of synthetic ACTH analogues in model neuronal systems. Journal of Neurochemistry, 2018.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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