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Epithalon

Epithalon

From 19,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: ET10 Category:
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Description

Epithalon

Synthetic tetrapeptide (Ala-Glu-Asp-Gly) for in vitro research on telomerase induction, telomere elongation, cellular senescence, and epigenetic modulation

Overview & Mechanism of Action (In Vitro)

Epithalon (also referred to as Epitalon or Epithalone) is a synthetic ultra-short peptide consisting of four amino acids with the sequence (Ala-Glu-Asp-Gly), designed based on the pineal gland bio-extract epithalamin. In molecular biogerontology, cellular biology, and genetic research, it serves as a primary model for investigating the mechanisms of cellular aging and genomic stability:

  • Induction of Telomerase Reverse Transcriptase (hTERT): Stimulation of transcriptional activity of the human telomerase reverse transcriptase (hTERT) catalytic subunit, reactivating telomerase enzyme activity and inducing telomeric repeat elongation in somatic cell models.
  • Overcoming the Hayflick Limit & Senescence Suppression: Investigating the peptide’s ability to delay replicative cellular senescence, expand the proliferative potential of cultured primary human fibroblasts, and reduce senescence-associated β-galactosidase (SA-β-gal) expression.
  • Epigenetic Regulation & Chromatin Remodeling: Site-specific interaction with DNA sequences and histone proteins, promoting heterochromatin decondensation and activating gene expression programs linked to DNA repair mechanisms.
  • Antioxidant & Neuroendocrine Signaling: Evaluating the upregulation of endogenous antioxidant enzymes (superoxide dismutase, glutathione peroxidase) and the modulation of circadian melatonin synthesis pathways in pineal cell cultures.

Technical & Chemical Specifications

  • Classification: Research Tetrapeptide / Telomerase Activator & Anti-Senescence Factor
  • Amino Acid Sequence: Ala-Glu-Asp-Gly (AEDG)
  • Form: Sterile lyophilized white powder (cake)
  • Component Identification: Verified via Mass Spectrometry (MS) and analytical HPLC
  • Recommended Reconstitution Solvent: Sterile bacteriostatic water or sterile phosphate-buffered saline (PBS)
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C and utilize within standard experimental protocol timelines.

Scientific References & Literature

  • Khavinson, V. K., et al. Synthetic peptide Epitalon stimulates telomerase activity and extends life span in human somatic cells in vitro. Bulletin of Experimental Biology and Medicine, 2003.
  • Khavinson, V. K., et al. Epigenetic aspects of peptide regulation of aging and gene expression. Biogerontology, 2014.
  • Anisimov, V. N., et al. Effect of Epithalon on biomarkers of aging, life span, and spontaneous carcinogenesis in experimental models. Experimental Gerontology, 2003.
  • Khavinson, V. K., & Bondarev, I. E. Epithalon stimulates gene expression of telomerase reverse transcriptase in human fibroblasts. Advances in Gerontology, 2004.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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