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GHRP - 6

GHRP – 6

From 14,90 €

  • Intended Use: This product is supplied strictly for laboratory, scientific, and research purposes only (Research Use Only / in vitro). It is not a medicinal product, food, or dietary supplement. The substance is not intended for human or animal consumption, administration, or therapeutic use.
  • Form & Contents: Supplied as a sterile lyophilized powder in a sealed laboratory vial. Does not include reconstitution solvent unless explicitly stated.
  • Recommended Storage: To maintain maximum stability, store the unopened vial in a cool, dry, and dark place at 2–8 °C (recommended at -20 °C for long-term storage).
  • Illustrative Product Image: Product images are for illustrative purposes only. The actual appearance of the vial, flip-off cap color, or laboratory label design may vary depending on the production batch.
Product code: G65 Category:
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Description

GHRP-6

Synthetic hexapeptide for in vitro research on growth hormone secretagogue receptor (GHS-R1a) signaling

Overview & Mechanism of Action (In Vitro)

GHRP-6 (Growth Hormone Releasing Peptide-6) is a first-generation synthetic hexapeptide with the sequence (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2). In biochemical, cellular, and molecular research, it serves as a primary reference ligand for investigating ghrelinergic signaling pathways and receptor kinetics:

  • Selective GHS-R1a Receptor Binding: Specific interaction with the binding domain of the G-protein coupled receptor on pituitary and neuronal cell lines.
  • Phospholipase Cascade Activation (PLC/IP3): Evaluation of intracellular calcium ion (Ca2+) flux and protein kinase C (PKC) phosphorylation without directly stimulating the adenylate cyclase pathway.
  • Cellular Protection & Metabolic Signaling: Investigation of downstream effects on mitochondrial membrane integrity, autophagy markers, and expression of anti-apoptotic proteins (e.g., Bcl-2 family) under oxidative stress conditions.

The presence of unnatural D-configured amino acids (D-Trp, D-Phe) combined with C-terminal amidation confers pronounced chemical resistance against serum-degrading proteases in experimental media.

Technical & Chemical Specifications

  • Classification: Research Peptide / First-Generation GHS-R1a Agonist
  • Amino Acid Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
  • Form: Sterile lyophilized white powder (cake)
  • Molecular Weight Identification: Confirmed via Mass Spectrometry (MS)
  • Recommended Reconstitution Solvent: Sterile bacteriostatic water or phosphate-buffered saline (PBS)
  • Storage Conditions: Store long-term at -20 °C in a dry, dark environment. Following reconstitution, keep refrigerated at 2–8 °C and utilize within standard experimental protocol timelines.

Scientific References & Literature

  • Momany, F. A., et al. Conformational energy analysis of growth hormone-releasing peptides. Endocrinology, 1984.
  • Bowers, C. Y., et al. On the in vitro mechanism of GH release by synthetic peptides. Endocrinology, 1980.
  • Camacho, V., et al. Cardioprotective and anti-apoptotic signaling pathways induced by GHRP-6 in cellular ischemia models. Growth Hormone & IGF Research, 2013.
  • Muccioli, G., et al. Neuroprotective and anti-inflammatory properties of GHS-R1a ligands in primary glial and neuronal cultures. Journal of Neuroendocrinology, 2007.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). This compound is not a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

Legal Disclaimer & Terms of Purchase

This product is classified and supplied strictly for laboratory, scientific, and in vitro research purposes only (Research Use Only – RUO). Neither the compound nor the capsule matrix is a drug, medicine, dietary supplement, cosmetic product, or substance intended for human or veterinary consumption, oral ingestion, direct administration, injection, or diagnostic procedures.

By placing an order, the purchaser explicitly confirms that they are at least 18 years of age, possess the requisite professional qualifications and laboratory equipment to safely handle research materials, and are fully conversant with all relevant safety protocols for managing research substances. The seller assumes no liability for any use contrary to these terms.

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